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7-Ethyl-10-hydroxycamptothecin

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7-Ethyl-10-hydroxycamptothecin Basic information
7-Ethyl-10-hydroxycamptothecin Chemical Properties
  • Melting point:217 °C
  • Boiling point:810.3±65.0 °C(Predicted)
  • Density 1.51±0.1 g/cm3(Predicted)
  • refractive index 21.5 ° (C=0.2, THF)
  • storage temp. −20°C
  • solubility DMSO: soluble1mg/mL
  • pka9.13±0.40(Predicted)
  • form powder
  • InChIKeyFJHBVJOVLFPMQE-QFIPXVFZSA-N
  • CAS DataBase Reference86639-52-3(CAS DataBase Reference)
Safety Information
  • Hazard Codes T
  • Risk Statements 25
  • Safety Statements 45
  • RIDADR 2811
  • WGK Germany 3
  • RTECS UQ0491000
  • HazardClass 6.1
  • PackingGroup 
  • HS Code 29399990
7-Ethyl-10-hydroxycamptothecin Usage And Synthesis
  • Chemical PropertiesLight-Yellow Solid
  • UsesA metabolite of Irinotecan, a DNA topoisomerase inhibitor
  • DefinitionChEBI: A member of the class of pyranoindolizinoquinolines that is (4S)-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14-dione bearing two additional ethyl substituents at positions 4 and 11 as well as two additional hydroxy substitu nts at positions 4 and 9. It is the active metabolite of irinotecan and is ~1000 times more active than irinotecan itself.
  • Biological ActivityActive metabolite of CPT-11 that inhibits DNA topoisomerase I (IC 50 values are 0.74 and 1.9 μ M in P388 and Ehrlich cells respectively). Inhibits DNA and RNA synthesis (IC 50 values are 0.077 and 1.3 μ M respectively) but does not affect protein synthesis. Displays potent antitumor activity against a range of human tumor cell lines (IC 50 values are 3.3, 13, 19 and 22 nM for HCT-116, BEL-7402, HL60 and HELA cells respectively).
7-Ethyl-10-hydroxycamptothecin Preparation Products And Raw materials
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