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7-Ethyl-10-hydroxycamptothecin

7-Ethyl-10-hydroxycamptothecin Structure
7-Ethyl-10-hydroxycamptothecin
  • CAS No.86639-52-3
  • Chemical Name:7-Ethyl-10-hydroxycamptothecin
  • CBNumber:CB5320664
  • Molecular Formula:C22H20N2O5
  • Formula Weight:392.4
  • MOL File:86639-52-3.mol
7-Ethyl-10-hydroxycamptothecin Property
  • Melting point: :217 °C
  • Boiling point: :810.3±65.0 °C(Predicted)
  • Density  :1.51±0.1 g/cm3(Predicted)
  • refractive index  :21.5 ° (C=0.2, THF)
  • storage temp.  :−20°C
  • solubility  :DMSO: soluble1mg/mL
  • pka :9.13±0.40(Predicted)
  • form  :powder
  • InChIKey :FJHBVJOVLFPMQE-QFIPXVFZSA-N
  • CAS DataBase Reference :86639-52-3(CAS DataBase Reference)
  • FDA UNII :0H43101T0J
Safety
  • Hazard Codes  :T
  • Risk Statements  :25
  • Safety Statements  :45
  • RIDADR  :2811
  • WGK Germany  :3
  • RTECS  :UQ0491000
  • HazardClass  :6.1
  • PackingGroup  :
  • HS Code  :29399990
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordDanger
  • Hazard statements H301+H311+H331-H301
  • Precautionary statements P301+P310-P261-P264-P270-P271-P280-P301+P310+P330-P302+P352+P312+P361+P364-P304+P340+P311-P403+P233-P405-P501
7-Ethyl-10-hydroxycamptothecin Price More Price(9)
  • Brand: Sigma-Aldrich
  • Product number: H0165
  • Product name : 7-Ethyl-10-hydroxycamptothecin
  • Purity: ≥98% (HPLC), powder
  • Packaging: 10mg
  • Price: $1160
  • Updated: 2020/08/18
  • Buy: Buy
  • Brand: Sigma-Aldrich
  • Product number: 1347631
  • Product name : Irinotecan Related Compound B
  • Purity: United States Pharmacopeia (USP) Reference Standard
  • Packaging: 10mg
  • Price: $1160
  • Updated: 2020/08/18
  • Buy: Buy
  • Brand: TCI Chemical
  • Product number: E0748
  • Product name : 7-Ethyl-10-hydroxycamptothecin
  • Purity: >98.0%(HPLC)
  • Packaging: 1g
  • Price: $260
  • Updated: 2020/06/24
  • Buy: Buy
  • Brand: TCI Chemical
  • Product number: E0748
  • Product name : 7-Ethyl-10-hydroxycamptothecin
  • Purity: >98.0%(HPLC)
  • Packaging: 100mg
  • Price: $45
  • Updated: 2020/06/24
  • Buy: Buy
  • Brand: Cayman Chemical
  • Product number: 15632
  • Product name : SN 38
  • Purity: ≥98%
  • Packaging: 10mg
  • Price: $74
  • Updated: 2020/06/24
  • Buy: Buy

7-Ethyl-10-hydroxycamptothecin Chemical Properties,Usage,Production

  • Chemical Properties Light-Yellow Solid
  • Uses A metabolite of Irinotecan, a DNA topoisomerase inhibitor
  • Definition ChEBI: A member of the class of pyranoindolizinoquinolines that is (4S)-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14-dione bearing two additional ethyl substituents at positions 4 and 11 as well as two additional hydroxy substitu nts at positions 4 and 9. It is the active metabolite of irinotecan and is ~1000 times more active than irinotecan itself.
  • Biological Activity Active metabolite of CPT-11 that inhibits DNA topoisomerase I (IC 50 values are 0.74 and 1.9 μ M in P388 and Ehrlich cells respectively). Inhibits DNA and RNA synthesis (IC 50 values are 0.077 and 1.3 μ M respectively) but does not affect protein synthesis. Displays potent antitumor activity against a range of human tumor cell lines (IC 50 values are 3.3, 13, 19 and 22 nM for HCT-116, BEL-7402, HL60 and HELA cells respectively).
7-Ethyl-10-hydroxycamptothecin Preparation Products And Raw materials
Raw materials
Preparation Products
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86639-52-3, 7-Ethyl-10-hydroxycamptothecinRelated Search:
  • 7-10-hydroxycamptothecin
  • (4S)-4,9-Dihydroxy-4,11-diethyl-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
  • (4S)-4,9-Dihydroxy-4α,11-diethyl-3,4,12,14-tetrahydro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14-dione
  • EHCPT
  • 7-Ethyl-10-hydroxy-CPT (Camptothecine), SN-38
  • 10-Hydroxycamptothecin acetate salt ,99%
  • Irinotecan Related Compound B (10 mg) ((S)-4,11-diethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione)
  • SN 38(7-Ethyl-10-hydroxycaMptothecin)
  • CaMptothecin, 7-ethyl-10-hydroxy (SN-38)
  • 7-Ethyl-10-hydroxy-20(S)-caMptothecin
  • (4S)-4,11-Diethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
  • 7-ETHYL-10-HYDRO(20)S-CAMPTOTHECIN
  • (S)-4,11-diethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
  • Irinotecan Related CoMpound B
  • 7-Ethyl-10-Hydroxy Campothecin
  • 7-Ethyl-10-hydroxycamptothecin (TECANS)
  • 7-ethyl-10-hydrol-Camptothecin
  • 7-ETHYL-10-HYDROXYCAMPTTHECIN(SN38)
  • 1H-Pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, 4,11-diethyl-4,9-dihydroxy-, (4S)-
  • 7-Ethyl-10-hydroxycamptothecin 4,11-Diethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
  • (S)-7-Ethyl-10-hydroxycamptothecin
  • 7-Ethyl-10-hydroxycamptothecin, >=99%
  • Crude Glycyrrhetinic Acid
  • SN-38:SN38
  • Irinotecan USP RC B
  • (4S)-4,11-Diethyl-4,9-Dihydroxy-1H-Pyrano[3,4
  • 6,7]Indolizino[1,2-B]Quinoline-3,14(4H,12H)-Dione
  • Irinotecan Impurity 15
  • NK 012
  • 7-etyl-10-hydroxycaMptothecin
  • 7,11-Diethyl-10- hydroxy-caMptothecin
  • Ethyl-10-hydroxycaMptoth
  • 11-Diethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
  • CaMptothecin 7-Ethyl-10-Hydroxy IMpurity
  • 7-ETHYL-10-HYDROXYCAMPTOTHECIN
  • 7-ETHYL-10-HYDROXYCAMPTOTHECINE
  • 7-ETHYL-10-HYDROXY-CPT
  • CAMPTOTHECIN, 7-ETHYL-10-HYDROXY
  • 4,11-Diethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
  • SN38
  • 10-dihydroxy-
  • 4’:6,7)indolizino(1,2-b)quinoline-3,14(4h,12h)-dione,4,7-diethyl-1h-pyrano(3
  • 7-ethyl-10-hydroxy-captotheci
  • 7-Ethyl-10-hydroxycamptothecin(SN-38)
  • SN 38 Lactone
  • 7-Ethyl-10-hydroxycamptothecin 86639-52-3
  • Irinotecan EP Impurity E
  • SN-38(NK-012)
  • (S)-7-ETHYL-10-HYDROXY CAMPTOTHECIN (IRINOTECAN EP IMPURITY E)
  • IRINOTECAN EP IMPURITY E ((S)-7-ETHYL-10-HYDROXY CAMPTOTHECIN)
  • (19S)-10,19-diethyl-7,19-dihydroxy-17-oxa-3,13-diazapentacyclo[11.8.0.0&#178
  • (S)-4,11-diethyl-4,9-dihydroxy-1H-benzo[f]pyrano[4',3':4,5]pyrido[2,1-a]isoindole-3,14(4H,12H)-dione
  • (S)-7-Ethyl-10-hydroxy campthothecin
  • 7-ethyl-10-hydroxycamptothecin 80-98%
  • 7-Ethyl-10-hydroxycamptothecin&gt
  • 86639-52-3
  • C22H20N2O5
  • Inhibitors