Basic information Safety Related Supplier
ChemicalBook >  Product Catalog >  API >  Antineoplastic agents >  Natural sources of antineoplastic >  Irinotecan

Irinotecan

Basic information Safety Related Supplier
Irinotecan Basic information
Irinotecan Chemical Properties
  • Melting point:222-223°
  • Boiling point:873.4±65.0 °C(Predicted)
  • Density 1.40±0.1 g/cm3(Predicted)
  • storage temp. 2-8°C
  • pka11.20±0.20(Predicted)
  • CAS DataBase Reference97682-44-5(CAS DataBase Reference)
Safety Information
Irinotecan Usage And Synthesis
  • UsesIrinotecan is a topoisomerase I inhibitor for LoVo cells and HT-29 cells with IC50 of 15.8 μM and 5.17 μM, respectively
  • DefinitionChEBI: A member of the class of pyranoindolizinoquinolines that is the carbamate ester obtained by formal condensation of the carboxy group of [1,4'-bipiperidine]-1'-carboxylic acid with the phenolic hydroxy group of (4S)-4,11-diethyl-4,9-dihydro y-1H-pyrano[3',4':6,7]indolizino[1,2- hydrochloride]quinoline-3,14-dione. Used (in the form of its hydrochloride salt trihydrate) in combination with fluorouracil and leucovorin, for the treatment of patients with metastatic adenocarcino a of the pancreas after disease progression following gemcitabine-based therapy. It is converted via hydrolysis of the carbamate linkage to its active metabolite, SN-38, which is ~1000 times more active.
  • brand nameCamptosar (Pharmacia &Upjohn) .
Irinotecan Preparation Products And Raw materials
Irinotecan(97682-44-5)Related Product Information
IrinotecanSupplierMore
  • Company Name:Wuhan Kai Lun new material Chemical Co Ltd Gold
  • Tel:025-87787262
  • Email:wshun@51chemall.com
  •  
  • Company Name:Lihe Wuhan New Chemical Materials Co., Ltd. Gold
  • Tel:027-88395709,15071332665
  • Email:gjing@51chemall.com
  •  
  • Company Name:Taizhou Hoyoo Chemical Co.,Ltd Gold
  • Tel:15057600339
  • Email:hoyoochem@yahoo.com;
  •  
  • Company Name:BOC Sciences Gold
  • Tel:16316197922
  • Email:info@bocsci.com
  •  
  • Company Name:Shanghai Boyle Chemical Co., Ltd.
  • Tel:
  • Email:sales@boylechem.com
  •  
Related articles