Basic information Selective EGFR inhibitor Safety Related Supplier

AZD 3759

Basic information Selective EGFR inhibitor Safety Related Supplier
AZD 3759 Basic information
AZD 3759 Chemical Properties
  • Boiling point:571.4±50.0 °C(Predicted)
  • Density 1.358±0.06 g/cm3(Predicted)
  • pka6.71±0.40(Predicted)
AZD 3759 Usage And Synthesis
  • Selective EGFR inhibitor

    AZD3759 is a selective EGFR inhibitor that can fully penetrate the blood-brain barrier (BBB), with equal free concentrations in the blood, cerebrospinal fluid, and brain tissue. Treatment with AZD3759 causes tumor regression in subcutaneous xenograft, leptomeningeal metastasis (LM), and brain metastasis (BM) lung cancer models and prevents the development of BM in nude mice.

  • DescriptionAZD3759 is an EGFP inhibitor (Epidermal growth factor receptor tyrosine kinase inhibitor) with blood brain barrier (BBB) penetration. It has the potential for the treatment of non-small cell lung cancer (NSCLC), with brain metastases (BM) and leptomengingeal metastases (LM) since this type of cancer often contain a lot of activating mutations of the epidermal growth factor receptor (EGFR). It has excellent capability of penetrating the blood brain barrier to reach the central nervous system. 
  • ReferencesZeng, Qingbei, et al. "Discovery and Evaluation of Clinical Candidate AZD3759, a Potent, Oral Active, Central Nervous System-Penetrant, Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor (EGFR TKI)." Journal of Medicinal Chemistry 58.20(2015):8200.
    Yang, Zhenfan, et al. "Abstract LB-217: Antitumor activities of AZD3759, a novel EGFR inhibitor with excellent penetration across central nervous system (CNS), in preclinical animal models." Cancer Research 76.14 Supplement(2016):LB-217-LB-217.
    Xiong, S., et al. "Determination of AZD3759 in rat plasma and brain tissue by LC-MS/MS and its application in pharmacokinetic and brain distribution studies." Journal of Pharmaceutical & Biomedical Analysis140(2017):362-366.
AZD 3759(1626387-80-1)Related Product Information
AZD 3759SupplierMore
  • Company Name:Guangzhou Zhiya Chemdrugs Co.,Ltd Gold
  • Tel:18122150900
  • Company Name:Shanghai Zhen Li Biological Technology Co., Ltd Gold
  • Tel:18516310516 1304-5646768-
  • Company Name:Nanjing Gold Pharmaceutical Technology Co. Ltd. Gold
  • Tel:15905158493
  • Company Name:Shandong Haiwo Biological Technology Co., Ltd. Gold
  • Tel:13046003282 0531-87586188-
  • Company Name:Shanghai Drjart Biological Co., Ltd. Gold
  • Tel:18616739945
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