Selective EGFR inhibitor
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AZD 3759

Selective EGFR inhibitor
AZD 3759 Structure
AZD 3759
  • CAS No.1626387-80-1
  • Chemical Name:AZD 3759
  • CBNumber:CB53041786
  • Molecular Formula:C22H23ClFN5O3
  • Formula Weight:459.9
  • MOL File:1626387-80-1.mol
AZD 3759 Property
  • Boiling point: :571.4±50.0 °C(Predicted)
  • Density  :1.358±0.06 g/cm3(Predicted)
  • pka :6.71±0.40(Predicted)
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal word
  • Hazard statements
  • Precautionary statements
AZD 3759 Price More Price(4)
  • Brand: Cayman Chemical
  • Product number: 19931
  • Product name : AZD 3759
  • Purity: ≥98%
  • Packaging: 1mg
  • Price: $25
  • Updated: 2021/03/22
  • Buy: Buy
  • Brand: Cayman Chemical
  • Product number: 19931
  • Product name : AZD 3759
  • Purity: ≥98%
  • Packaging: 5mg
  • Price: $81
  • Updated: 2021/03/22
  • Buy: Buy
  • Brand: Cayman Chemical
  • Product number: 19931
  • Product name : AZD 3759
  • Purity: ≥98%
  • Packaging: 10mg
  • Price: $150
  • Updated: 2021/03/22
  • Buy: Buy
  • Brand: Cayman Chemical
  • Product number: 19931
  • Product name : AZD 3759
  • Purity: ≥98%
  • Packaging: 25mg
  • Price: $281
  • Updated: 2021/03/22
  • Buy: Buy

AZD 3759 Chemical Properties,Usage,Production

  • Selective EGFR inhibitor

    AZD3759 is a selective EGFR inhibitor that can fully penetrate the blood-brain barrier (BBB), with equal free concentrations in the blood, cerebrospinal fluid, and brain tissue. Treatment with AZD3759 causes tumor regression in subcutaneous xenograft, leptomeningeal metastasis (LM), and brain metastasis (BM) lung cancer models and prevents the development of BM in nude mice.

  • Description AZD3759 is an EGFP inhibitor (Epidermal growth factor receptor tyrosine kinase inhibitor) with blood brain barrier (BBB) penetration. It has the potential for the treatment of non-small cell lung cancer (NSCLC), with brain metastases (BM) and leptomengingeal metastases (LM) since this type of cancer often contain a lot of activating mutations of the epidermal growth factor receptor (EGFR). It has excellent capability of penetrating the blood brain barrier to reach the central nervous system. 
  • References Zeng, Qingbei, et al. "Discovery and Evaluation of Clinical Candidate AZD3759, a Potent, Oral Active, Central Nervous System-Penetrant, Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor (EGFR TKI)." Journal of Medicinal Chemistry 58.20(2015):8200.
    Yang, Zhenfan, et al. "Abstract LB-217: Antitumor activities of AZD3759, a novel EGFR inhibitor with excellent penetration across central nervous system (CNS), in preclinical animal models." Cancer Research 76.14 Supplement(2016):LB-217-LB-217.
    Xiong, S., et al. "Determination of AZD3759 in rat plasma and brain tissue by LC-MS/MS and its application in pharmacokinetic and brain distribution studies." Journal of Pharmaceutical & Biomedical Analysis140(2017):362-366.
AZD 3759 Preparation Products And Raw materials
Raw materials
Preparation Products
Global(206)Suppliers
  • Supplier:
    AFINE CHEMICALS LIMITED
  • Tel:008657185134551
  • Fax:008657185134895
  • Email:info@afinechem.com
  • Country:CHINA
  • ProdList:15559
  • Advantage:58
  • Supplier:
    Henan Tianfu Chemical Co.,Ltd.
  • Tel:0371-55170693
  • Fax:0371-55170693
  • Email:info@tianfuchem.com
  • Country:CHINA
  • ProdList:22607
  • Advantage:55
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  • High Purity Azd 3759 CAS:
  • High Purity Azd3759/Azd-3759 CAS 1626387-80-1 with Steady Supply
  • Anti Cancer Azd3759, High Purity
  • AZD3759 Powder
  • 1626387-80-1
  • 626387-80-1
  • C22H23ClFN5O3
  • API