Ethyl 3-phenylpropionate

clear colorless to light yellow liquid

Ethyl 3-phenylpropionate has an ethereal, rum, fruity, floral odor.

Reported found in rum, passion fruit, plum brandy, caja fruit (Spondias lutea L.) and checkur (Alpinia sessilis).

Ethyl 3-phenylpropionate is used as an active pharmaceutical ingredient intermediate. It is also used in the synthesis of pyrimidine based inhibitors of cyclin-dependant kinases.

By hydrogenation of the corresponding ethyl cinnamate in the presence of nickel in alcohol solution.

ChEBI: Ethyl 3-phenylpropanoate is a fatty acid ester.

Detection: 17 to 40 ppb

The Journal of Organic Chemistry, 50, p. 3406, 1985 DOI: 10.1021/jo00218a033
Synthetic Communications, 22, p. 2683, 1992 DOI: 10.1080/00397919208021668
Tetrahedron Letters, 42, p. 781, 2001 DOI: 10.1016/S0040-4039(00)02176-6

Clear colorless liquid.

Insoluble in water.

Ethyl 3-phenylpropionate is an ester. Esters react with acids to liberate heat along with alcohols and acids. Strong oxidizing acids may cause a vigorous reaction that is sufficiently exothermic to ignite the reaction products. Heat is also generated by the interaction of esters with caustic solutions. Flammable hydrogen is generated by mixing esters with alkali metals and hydrides.

The flash point of Ethyl 3-phenylpropionate has not been determined. but Ethyl 3-phenylpropionate is probably combustible.

Ethyl 3-phenylpropionate is synthesized by Hydrocinnamic acid and Ethanol by normal esterification.