General procedure for the synthesis of 3-(N-Boc-aminomethyl)benzoic acid from methyl 3-(((tert-butoxycarbonyl)amino)methyl)benzoate: to a solution of methyl 3-(((tert-butoxycarbonyl)amino)methyl)benzoate (0.6 g, 2.20 mmol) in tetrahydrofuran (THF, 4 mL) at 25°C was added lithium hydroxide (0.3 g, 9.0 mmol) solution in water (2 mL). The reaction mixture was stirred at 50°C for 4 hours. Upon completion of the reaction, THF was removed by distillation under reduced pressure, the reaction mixture was acidified with acetic acid, and the product was subsequently extracted with ethyl acetate. The organic phase was dried with anhydrous sodium sulfate, filtered and concentrated to give the crude product. The crude product was purified by column chromatography to give 3-(N-Boc-aminomethyl)benzoic acid as a colorless solid (250 mg, 44% yield).
