盐酸罗哌卡因
盐酸罗哌卡因 性质
| 熔点 | 260-262° |
|---|---|
| 比旋光度 | D25 -6.6° (c = 2 in water) |
| 储存条件 | Store at -20°C |
| 形态 | 固体 |
| 颜色 | 白色至米白色 |
| 水溶解性 | ≥ 10.1mg/mL in Water |
| InChI | InChI=1S/C17H26N2O.ClH/c1-4-11-19-12-6-5-10-15(19)17(20)18-16-13(2)8-7-9-14(16)3;/h7-9,15H,4-6,10-12H2,1-3H3,(H,18,20);1H |
| InChIKey | NDNSIBYYUOEUSV-UHFFFAOYSA-N |
| SMILES | N1(CCC)CCCCC1C(NC1=C(C)C=CC=C1C)=O.[H]Cl |
| CAS 数据库 | 98717-15-8(CAS DataBase Reference) |
盐酸罗哌卡因 用途与合成方法
高浓度时, 布吡卡因对A类和C类神经纤维的复合动作电位的抑制作用分别比盐酸罗派卡因强16%和3%,表明盐酸罗派卡因和布吡卡因的感觉阻滞作用类似,但盐酸罗派卡因的运动阻滞作用弱。低浓度时, 盐酸罗派卡因主要阻滞感觉神经纤维,对运动神经纤维的阻滞轻,即盐酸罗派卡因具有高度的感觉与运动神经阻滞分离的特性,对术后硬膜外镇痛有独特的优点。 Ropivacaine hydrochloride 是一种有效的钠通道 (sodium channel) 阻断剂。Ropivacaine 通过可逆地抑制钠离子内流 (sodium ion influx) 从而引起神经纤维脉冲传导阻滞。Ropivacaine 也是一种 K2P (双孔钾通道) TREK-1 的抑制剂，在 COS-7 细胞膜上的 IC50 值为 402.7 μM。Ropivacaine 在动物实验模型中，可用于局部麻醉和神经性疼痛的缓解。
IC50: sodium ion influxIC50: 402.7 μM (TREK-1 in COS-7 cell's membrane)
Epidural administration of Ropivacaine hydrochloride effectively blocks neuropathic pain (both mechanical allodynia and heat hyperalgesia) without induction of analgesic tolerance and significantly delays the development of neuropathic pain produced by peripheral nerve injury.
Ropivacaine hydrochloride inhibits pressure-induced increases in filtration coefficient (Kf) without affecting pulmonary artery pressure (Ppa), pulmonary capillary pressures (Ppc), and zonal characteristics (ZC).
Ropivacaine hydrochloride prevents pressure-induced lung edema and associated hyperpermeability as evidence by maintaining PaO2, lung wet-to-dry ratio and plasma volume in levels similar to sham rats.
Ropivacaine hydrochloride inhibits pressure-induced NO production as evidenced by decreased lung nitro-tyrosine content when compared to hypertensive lungs.
| Animal Model: | Adult Sprague-Dawley rats (300–400g) |
| Dosage: | 1 μM |
| Administration: | Infusion (added to the perfusate reservoir) |
| Result: | Attenuated pressure-dependent increases in filtration coefficient (K f ). |
盐酸罗哌卡因 价格(试剂级)
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024-11-08 | 46722 | 盐酸罗哌卡因 | 98717-15-8 | 250mg | 2283 |
| 2024-11-08 | 46722 | 盐酸罗哌卡因 | 98717-15-8 | 1g | 8462 |
