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2-(4-((2-(4-(Trifluoromethyl)phenyl)-5-methylthiazol-4-yl)methylthio)-2-methylphenoxy)acetic acid

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2-(4-((2-(4-(Trifluoromethyl)phenyl)-5-methylthiazol-4-yl)methylthio)-2-methylphenoxy)acetic acid Basic information
2-(4-((2-(4-(Trifluoromethyl)phenyl)-5-methylthiazol-4-yl)methylthio)-2-methylphenoxy)acetic acid Chemical Properties
  • Melting point:134-136°C
  • Boiling point:584.5±60.0 °C(Predicted)
  • Density 1.42±0.1 g/cm3(Predicted)
  • storage temp. Refrigerator
  • solubility DMSO: soluble20mg/mL, clear
  • pka3.17±0.10(Predicted)
  • form powder
  • color white to beige
  • BRN 18515150
  • Stability:Light Sensitive
  • InChIKeyYDBLKRPLXZNVNB-UHFFFAOYSA-N
  • CAS DataBase Reference317318-70-0
Safety Information
  • WGK Germany 3
  • RTECS AI9105500
2-(4-((2-(4-(Trifluoromethyl)phenyl)-5-methylthiazol-4-yl)methylthio)-2-methylphenoxy)acetic acid Usage And Synthesis
  • Chemical PropertiesWhite Solid
  • UsesAn experimental drug meant to control lipids and increase the level of HDL, or good cholesterol, in the bloodstream. A cell-permeable, thiazolyl compound that acts as a potent, high affinity, PPARd agonist. Exhibits selectivity for PPARd compared t
  • UsesAn experimental drug meant to control lipids and increase the level of HDL, or good cholesterol, in the bloodstream. A cell-permeable, thiazolyl compound that acts as a potent, high affinity, PPARδ agonist. Exhibits selectivity for PPARδ compared to PPARα and PPARγ. Does not exibit any activity against other nuclear or non-nuclear receptors. Reported to increase cholesterol efflux and ABAC1 expression in macrophages, fibroblasts, and intestinal cells.
  • DefinitionChEBI: An aromatic ether that is phenoxyacetic acid in which the phenyl group is substituted at position 2 by a methyl group and at position 4 by a (1,3-thiazol-5-ylmethyl)sulfanediyl group, and in which the 1,3-thiazolyl group is substituted at positions 2 and 4 by p-trifluoromethylphenyl and methyl groups, respectively.
2-(4-((2-(4-(Trifluoromethyl)phenyl)-5-methylthiazol-4-yl)methylthio)-2-methylphenoxy)acetic acid(317318-70-0)Related Product Information
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