2-Amino-5-chloro-3-iodopyridine

1072-98-6

211308-81-5

GENERAL STEPS: 24,150 mL of a solvent mixture of tetrahydrofuran and 50 L of ethylene dichloride were added to an 8000 mL reactor, a plug-in thermometer was installed and a mechanical stirrer was started. Subsequently, 6037.5 g of 2-amino-5-chloropyridine and 18528 g of N-iodosuccinimide were added to the reactor. The reaction mixture was stirred continuously at 53 °C for 7 hours. The progress of the reaction was monitored by thin layer chromatography (TLC) and gas chromatography (GC) to confirm the complete reaction of 2-amino-5-chloropyridine. Upon completion of the reaction, the solvent was removed using a rotary evaporator to give the crude product. The crude product was recrystallized by a solvent mixture of ethyl acetate and ethanol to obtain purified 2-amino-3-iodo-5-chloropyridine. The product was dried and the calculated yield was 90.10% and the purity was 98.2% by GC.