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Description
Pregnenolone serves as the common precursor in the formation of the adrenocorticoids and other steroid
hormones. This C21 steroid is converted via enzymatic oxidations and isomerization of the double bond to a
number of physiologically active C21 steroids, including the female sex hormone progesterone and the
adrenocorticoids hydrocortisone (cortisol), corticosterone, and aldosterone. Oxidative cleavage of the
two-carbon side chain of pregnenolone and subsequent enzymatic oxidations and isomerization lead to C19
steroids, including the androgens testosterone and dihydrotestosterone. The final group of steroids, the C18
female sex hormones, are derived from oxidative aromatization of the A ring of androgens to produce estrogens.
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Description
Pregnenolone is a natural steroid hormone that serves as a precursor for a wide range of steroids, including mineralocorticoids, glucocorticoids, androgens, and estrogens.1 Pregnenolone sulfate modulates NMDA receptor responses to exogenously applied glutamate and stimulates transient receptor potential melastatin 3 (TRPM3).2,3,4
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Chemical Properties
white to off-white powder
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Uses
Pregnenolone is a steroid hormone involved in the steroidogenesis of progesterone, mineralocorticoids, glucocorticoids, androgens, and estrogens. As such it is a prohormone. Pregnenolone is a GABAA an
tagonist and increases neurogenesis in the hippocampus. It is a modulator of cytochrome P 450-3A
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Uses
glucocortcoid, antiinflammatory
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Definition
ChEBI: A 20-oxo steroid that is pregn-5-ene substituted by a beta-hydroxy group at position 3 and an oxo group at position 20.
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General Description
Pregnenolone is an endogenous steroid hormone involved in the biological synthesis of other hormones. Pregnenolone is monitored as an ancillary test for congenital adrenal hyperplasia (CAH), particularly in situations where diagnosis of 21-hydroxylase and 11-hydroxylase deficiency has been ruled out. This Certified Spiking Solution? is suitable for use in LC-MS/MS testing methods as a starting material in the preparation of calibrators, controls and linearity standards.
