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Pregnenolone Basic information
Pregnenolone Chemical Properties
  • Melting point:188-190 °C
  • alpha 28.5 º (c=1, EtOH)
  • Boiling point:395.89°C (rough estimate)
  • Density 1.0382 (rough estimate)
  • refractive index 1.5344 (estimate)
  • Flash point:9℃
  • storage temp. Refrigerator
  • solubility ethanol: soluble10mg/mL, clear, colorless to faintly yellow
  • pka15.00±0.70(Predicted)
  • form Powder
  • color White to off-white
  • Water Solubility 41mg/L(room temperature)
  • Merck 7733
  • BRN 2059026
  • CAS DataBase Reference145-13-1(CAS DataBase Reference)
  • NIST Chemistry ReferencePregnenolone(145-13-1)
Safety Information
  • Safety Statements 22-24/25
  • RIDADR UN 1648 3 / PGII
  • WGK Germany 3
  • RTECS TU5560700
  • HS Code 29372900
Pregnenolone Usage And Synthesis
  • DescriptionPregnenolone serves as the common precursor in the formation of the adrenocorticoids and other steroid hormones. This C21 steroid is converted via enzymatic oxidations and isomerization of the double bond to a number of physiologically active C21 steroids, including the female sex hormone progesterone and the adrenocorticoids hydrocortisone (cortisol), corticosterone, and aldosterone. Oxidative cleavage of the two-carbon side chain of pregnenolone and subsequent enzymatic oxidations and isomerization lead to C19 steroids, including the androgens testosterone and dihydrotestosterone. The final group of steroids, the C18 female sex hormones, are derived from oxidative aromatization of the A ring of androgens to produce estrogens.
  • Chemical Propertieswhite to off-white powder
  • Usesglucocortcoid, antiinflammatory
  • UsesPregnenolone is a steroid hormone involved in the steroidogenesis of progesterone, mineralocorticoids, glucocorticoids, androgens, and estrogens. As such it is a prohormone. Pregnenolone is a GABAA an tagonist and increases neurogenesis in the hippocampus. It is a modulator of cytochrome P 450-3A
  • DefinitionChEBI: A 20-oxo steroid that is pregn-5-ene substituted by a beta-hydroxy group at position 3 and an oxo group at position 20.
Pregnenolone Preparation Products And Raw materials
Pregnenolone(145-13-1)Related Product Information
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