A hyponotic-anaesthetic agent.
ChEBI: The 3alpha-stereoisomer of 3-hydroxy-5beta-pregnan-20-one.
GABA A receptor positive allosteric modulator. Neuroactive steroid.
5β-Pregnan-3α-ol-20-one or pregnanolone is a neurosteroid that acts as a positive allosteric modulator (PAMs) of γ-aminobutyric acid A receptors (GABAARs). It mediates anti-convulsive, anxiolytic and sedative effects. Pregnanolone inhibits γ-aminobutyric acid C receptor (GABAC) receptor-based response and favors GABAA?receptor-mediated currents.