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SB 203580

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SB 203580 Basic information
SB 203580 Chemical Properties
  • Melting point:144-146
  • Boiling point:615.6±55.0 °C(Predicted)
  • Density 1.4
  • storage temp. −20°C
  • solubility DMSO: 50 mg/mL
  • pka9.60±0.10(Predicted)
  • form solid
  • color white to off-white
  • Stability:-200C
  • InChIKeyCDMGBJANTYXAIV-UHFFFAOYSA-N
  • CAS DataBase Reference152121-47-6(CAS DataBase Reference)
Safety Information
  • Hazard Codes Xn
  • Risk Statements 22-41
  • Safety Statements 26-39
  • WGK Germany 3
  • HS Code 29333990
MSDS
SB 203580 Usage And Synthesis
  • Chemical PropertiesWhite to Off-White Solid
  • UsesA pyridinyl imidazole which acts as a specific inhibitor of p38 MAP kinase. Does not inhibit the MAP kinase homologs JNK and p42 MAP kinase
  • UsesA p38 MAPK inhibitor with an IC50 range of 0.3-0.5 μM and blocks PKB phosphorylation with an IC50 range of 3-5 μM.
  • DefinitionChEBI: A member of the class of imidazoles carrying 4-methylsulfinylphenyl, 4-pyridyl and 4-fluorophenyl substituents at positions 2, 4 and 5 respectively. An inhibitor of mitogen-activated protein kinase.
  • Biological ActivityWater-soluble salt of SB 203580 (4-[5-(4-Fluorophenyl)-2-[4-(methylsulfonyl)phenyl]-1H-imidazol-4-yl]pyridine ). Selective inhibitor of p38 mitogen-activated protein kinase (IC 50 values are 50 and 500 nM for SAPK2a/p38 and SAPK2b/p38 β 2 respectively). Displays 100-500-fold selectivity over LCK, GSK3 β and PKB α . Shown to inhibit interleukin-2-induced T-cell proliferation, cyclooxygenase-1 and -2, and thromboxane synthase.
SB 203580(152121-47-6)Related Product Information
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  • Company Name:Shanghaizehan biopharma technology co., Ltd. Gold
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