ChemicalBook > Product Catalog > Biochemical Engineering > Inhibitors > Mitogen-activated protein kinase (MAPK) > p38 MAPK inhibitor > SB 203580
SB 203580
- Product Name:SB 203580
- CAS:152121-47-6
- MF:C21H16FN3OS
- MW:377.43
- EINECS:
- Mol File:152121-47-6.mol
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SB 203580 Chemical Properties
- Melting point:144-146
- Boiling point:615.6±55.0 °C(Predicted)
- Density 1.4
- storage temp. −20°C
- solubility DMSO: 50 mg/mL
- pka9.60±0.10(Predicted)
- form solid
- color white to off-white
- Stability:-200C
- InChIKeyCDMGBJANTYXAIV-UHFFFAOYSA-N
- CAS DataBase Reference152121-47-6(CAS DataBase Reference)
- Language:EnglishProvider:SigmaAldrich
SB 203580 Usage And Synthesis
- Chemical PropertiesWhite to Off-White Solid
- UsesA pyridinyl imidazole which acts as a specific inhibitor of p38 MAP kinase. Does not inhibit the MAP kinase homologs JNK and p42 MAP kinase
- UsesA p38 MAPK inhibitor with an IC50 range of 0.3-0.5 μM and blocks PKB phosphorylation with an IC50 range of 3-5 μM.
- DefinitionChEBI: A member of the class of imidazoles carrying 4-methylsulfinylphenyl, 4-pyridyl and 4-fluorophenyl substituents at positions 2, 4 and 5 respectively. An inhibitor of mitogen-activated protein kinase.
- Biological ActivityWater-soluble salt of SB 203580 (4-[5-(4-Fluorophenyl)-2-[4-(methylsulfonyl)phenyl]-1H-imidazol-4-yl]pyridine ). Selective inhibitor of p38 mitogen-activated protein kinase (IC 50 values are 50 and 500 nM for SAPK2a/p38 and SAPK2b/p38 β 2 respectively). Displays 100-500-fold selectivity over LCK, GSK3 β and PKB α . Shown to inhibit interleukin-2-induced T-cell proliferation, cyclooxygenase-1 and -2, and thromboxane synthase.
- U0126-EtOH MK-2206 2HCl 1,9-Pyrazoloanthrone PD 98059 SCH772984 LY 294002 HYDROCHLORIDE SB-203580 IN SOLUTION P38 INHIBITOR (SB 203580),SAPK2 INHIBITOR (SB 203580) SB 203580, 99+% SB 203580, IODO- SB 203580, SULFONE 2-(4-METHYLSULFANYL-PHENYL)-1H-IMIDAZOLE 4-(3H-Imidazol-4-yl)-pyridine SB 203580 2,4-Diphenylimidazole 4-METHYL-2,5-DIPHENYLIMIDAZOLE 4-[5-(4-FLUORO-PHENYL)-2-(4-METHANESULFONYL-PHENYL)-3H-IMIDAZOL-4-YL]-PYRIDINE
SB 203580SupplierMore
- Company Name:Shanghaizehan biopharma technology co., Ltd. Gold
- Tel:13052117465
- Email:sales@zehanbiopharma.com;
- Company Name:YouCoChem (Beijing) Chemical Technology Co., Ltd. Gold
- Tel:18800159827/1399050885(QQ)
- Email:youcochem@163.com
- Company Name:Shanghai Boyle Chemical Co., Ltd.
- Tel:
- Email:sales@boylechem.com
- Company Name:J & K SCIENTIFIC LTD.
- Tel:400-666-7788 010-82848833-
- Email:jkinfo@jkchemical.com;market6@jkchemical.com
- Company Name:3B Pharmachem (Wuhan) International Co.,Ltd.
- Tel:18930552037 821-50328103-801
- Email:3bsc@sina.com