(E/Z)-Zotiraciclib (50 and 75 mg/kg; p.o. once daily for 3 weeks) inhibits tumor growth[1].
(E/Z)-Zotiraciclib (15 and 75 mg/kg; p.o. once daily 2 days on and 5 days off; i.p. once daily 5 days on 5 days off) inhibits tumor growth in two manners[1].
| Animal Model: | Male BALB/c mice with HCT-116 colon cancer cells xenografts[1] |
| Dosage: | 50 and 75 mg/kg |
| Administration: | Oral gavage; 50 and 75 mg/kg once daily for 3 weeks |
| Result: | Significantly inhibited the growth of tumors with a mean TGI of 82%.
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| Animal Model: | Male BALB/c mice with lymphoma Ramos cells xenografts[1] |
| Dosage: | 15 and 75 mg/kg |
| Administration: | Oral gavage and intraperitoneal injection ; 75 mg/kg once daily 2 days on and 5 days off (p.o.) and 15 mg/kg once daily 5 days on 5 days off (i.p.) |
| Result: | Significantly inhibited the growth of tumors with mean TGIs of 42% and 63% for the oral and ip delivery methods, respectively.
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