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LY 294002 HYDROCHLORIDE

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LY 294002 HYDROCHLORIDE Basic information
LY 294002 HYDROCHLORIDE Chemical Properties
  • Melting point:183-185℃
  • Boiling point:494.6±45.0 °C(Predicted)
  • Density 1.266
  • storage temp. 2-8°C
  • solubility DMSO: >5 mg/mL
  • pka0.55±0.20(Predicted)
  • form solid
  • color white to off-white
  • Water Solubility Soluble in DMSO at 5mg/ml. Insoluble in water
  • InChIKeyCZQHHVNHHHRRDU-UHFFFAOYSA-N
  • CAS DataBase Reference154447-36-6
Safety Information
  • Safety Statements 24-25
  • WGK Germany 3
  • HS Code 29349990
MSDS
LY 294002 HYDROCHLORIDE Usage And Synthesis
  • UsesA potent blocker of PI 3-kinase/Akt signaling.
  • UsesLY294002 is a selective phosphatidylinositol 3-kinase (PI3K) inhibitor with a 2.7-fold greater potency than quercetin. LY294002 inhibits purified PI3K with an IC50 of 1.4 μM.
  • DefinitionChEBI: A chromone substituted with a phenyl group at position 8 and a morpholine group at position 2.
  • Biological ActivityA highly selective inhibitor of phosphatidylinositol 3-kinase (IC 50 values are 0.31, 0.73, 1.06 and 6.60 μ M for PI3K β , PI3K α , PI3K δ and PI3K γ respectively). Inhibits proliferation and induces apoptosis in human colon cancer cells in vitro and in vivo .
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