ChemicalBook Product Catalog Biochemical Engineering Biochemical Reagents Biological Dyes Hematoxylin

Hematoxylin

Product NameHematoxylin
CAS517-28-2
MFC16H14O6
MW302.28
EINECS208-237-3
MOL File517-28-2.mol

Chemical Properties

Melting point	200 °C (dec.)(lit.)
Boiling point	363.32°C (rough estimate)
Density	1.2514 (rough estimate)
vapor pressure	0-0Pa at 20-25℃
refractive index	1.4600 (estimate)
storage temp.	Keep in dark place,Inert atmosphere,Room temperature
solubility	Soluble in 95% ethanol(1 mg/mL).
form	Powder/Solid
Colour Index	75290
pka	6.7(at 25℃)
color	Yellow to Brown
PH Range	Red (0.0) to yellow (1.0);Pale yellow (5.0) to violet (6.0)
Water Solubility	SOLUBLE IN HOT WATER
Sensitive	Light Sensitive
λmax	292nm, 445nm, 560nm
Merck	14,4637
BRN	91399
Stability	Stable, but may discolour on exposure to light. Incompatible with strong oxidizing agents.
Major Application	Plasma displays, textiles, hair dyes, identifying fresh and stale rice, diag-nosing cancer progression, detecting nosing cancer progression, cervical disease, central nervous system malfunctions, detecting genes, breast cancer, collagen in a tissue sample, apoptosis, demyelinating diseases, antigens, treatment of age-related macular degeneration, burns, prostate cancer, diabetesand obesity, viral diseases, neoplasms, peripheral neural and vascular ailments, skin disorders, biotechnological applications, reference standard materials for cytology, histology andimmunohistochemistry
InChIKey	WZUVPPKBWHMQCE-UHFFFAOYSA-N
LogP	0.3 at 30℃ and pH6.9
CAS DataBase Reference	517-28-2
EPA Substance Registry System	Hematoxylin (517-28-2)

Safety Information

Hazard Codes	Xn,Xi
Risk Statements	22-36/37/38
Safety Statements	26-36
WGK Germany	2
RTECS	MH7875000
TSCA	Yes
HS Code	32030019
Hazardous Substances Data	517-28-2(Hazardous Substances Data)

MSDS

Provider	Language
7,11b-Dihydrobenz[b]indeno[1,2-d]pyran-3,4,6a,9,10(6H)-pentol	English
SigmaAldrich	English

Usage And Synthesis

Chemical Properties

light brown crystals or powder

Uses

Hematoxylin and eosin together make up Hematoxylin and eosin stain, one of the most commonly used stains in histology. Metal-haematein complexes are used to stain cell nuclei prior to examination under a microscope. Structures that stain with iron- or aluminum-haematein are often called basophilic, even though the mechanism of the staining is different from that of staining with basic dyes.

Uses

Colorant in inks, biological stains.

Definition

ChEBI: (+)-haematoxylin is a haematoxylin. It is an enantiomer of a (-)-haematoxylin.

General Description

White to yellowish crystals that redden on exposure to light.

Air & Water Reactions

Soluble in hot water, slightly water soluble in cold .

Reactivity Profile

Sensitive to light. .

Hazard

May be carcinogenic.

storage

Store at RT

Purification Methods

Hematoxylin recrystallises from H2O (as trihydrate) in white-yellow crystals which become red on exposure to light and then melt at 100-120o. It has been recrystallised from Me2CO/*C6H6. It has been recrystallised as well from dilute aqueous NaHSO3 until colourless and is soluble in alkali, borax and glycerol. Store it in the dark below 0o. [Morsingh & Robinson Tetrahedron 26 182 1970, Dann & Hofmann Chem Ber 98 1498 1955, Beilstein 17/8 V 469.]

Hematoxylin

Chemical Properties

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MSDS

Usage And Synthesis

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