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Direct Blue 53

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Direct Blue 53 Basic information
Direct Blue 53 Chemical Properties
  • storage temp. Store at RT.
  • Colour Index 23860
  • form Powder/Solid
  • color Dark Brown
  • Water Solubility 280 g/L (20 ºC)
  • Merck 14,3905
  • Stability:Stable. Incompatible with strong reducing agents, strong oxidizing agents.
  • CAS DataBase Reference314-13-6
  • IARC3 (Vol. 8, Sup 7) 1987
  • EPA Substance Registry SystemC.I. Direct Blue 53 (314-13-6)
Safety Information
Direct Blue 53 Usage And Synthesis
  • Chemical Propertiesbrownish crystalline powder
  • Usesantineoplastic
  • DefinitionChEBI: An organic sodium salt that is the tetrasodium salt of 6,6'-{(3,3'-dimethyl[1,1'-biphenyl]-4,4'-diyl)bis[diazene-2,1-diyl]}bis(4-amino-5-hydroxynaphthalene-1,3-disulfonate). It is sometimes used as a counterstain, especially in fluorescent methods to suppr ss background autofluorescence.
  • General DescriptionBlue crystals with a greenish-bronze luster or a black powder.
  • Air & Water ReactionsAzo dyes can be explosive when suspended in air at specific concentrations. Soluble in water.
  • Reactivity ProfileDirect Blue 53 is an azo compound. Azo, diazo, azido compounds can detonate. This applies in particular to organic azides that have been sensitized by the addition of metal salts or strong acids. Toxic gases are formed by mixing materials of this class with acids, aldehydes, amides, carbamates, cyanides, inorganic fluorides, halogenated organics, isocyanates, ketones, metals, nitrides, peroxides, phenols, epoxides, acyl halides, and strong oxidizing or reducing agents. Flammable gases are formed by mixing materials in this group with alkali metals. Explosive combination can occur with strong oxidizing agents, metal salts, peroxides, and sulfides. Direct Blue 53 can react with strong reducing and oxidizing agents.
  • Fire HazardFlash point data for Direct Blue 53 are unavailable; however, Direct Blue 53 is probably combustible.
  • Biological ActivityPotent inhibitor of L-glutamate uptake into synaptic vesicles. Also inhibits AMPA and kainate receptor-mediated currents (IC 50 values are 220 and 150 nM respectively). P2X-selective purinoceptor antagonist.
  • Safety ProfilePoison by intraperitoneal route.Moderately toxic by intravenous route. An experimentalteratogen. Other experimental reproductive effects.Questionable carcinogen with experimental tumorigenicdata. Mutation data reported. When heated todecomposition it
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