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ChemicalBook Product Catalog API Diagnostic agents Organ Function Test agent Evans blue

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Evans blue NEW

$41.00 50mg

$50.00 100mg

Min. Order
Purity98.85%
Cas No314-13-6
Supply Ability10g
Update time2024-11-19

TargetMol Chemicals Inc.

TargetMol Chemicals Inc.

1YR

United States

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Chemical Properties

Product Name	Evans blue
CAS No	314-13-6
EC-No
Min. Order
Purity	98.85%
Supply Ability	10g
Release date	2024/11/19

Product Introduction

Bioactivity

Name	Evans blue
Description	Evans blue (C.I. 23860) is an azo dye, inhibits L-glutamate uptake via the membrane-bound excitatory amino acid transporter (EAAT).
In vitro	Evans Blue is found to be inhibiting DNA binding of NF-κB at a low concentration of 100 μM[1]. It has proven over the years to be a dependable stain for microscopic determination of cell death[2]. Evans Blue is also a known blocker of a subset of a-amino-3-hydroxy-5-methyl-isoxazole/kainate receptors (IC50=355 nM) for the subunit combination GluR1,2[5]. Evans blue is the first known δ-subunit-specific antagonist of ENaC and activates large-conductance Ca2+-activated K+ channels in sheep bladder myocytes and cultured endothelial cells of human umbilical veins[5].
In vivo	Evans blue pretreatment could inhibit the mast cells degranulation and that may be the main mechanism for prevent animals from C48/80-triggered anaphylaxis and systemic inflammation[4]. Evans blue modulates the non-N-methyl-d-aspartate receptor in rat thalamic neurons, blocks the P2X-purinergic receptor in rat vas deferens, and inhibits the glutamate transporter in rat brain synaptic vesicles[6].
Storage	keep away from direct sunlight \| Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice.
Solubility Information	H2O : 104.1 mM DMSO : 104.1 mM
Keywords	Direct Blue-53 \| inhibit \| Inhibitor \| Direct Blue53 \| Evans blue
Inhibitors Related	IDRA-21 \| Decanoic Acid \| Urethane \| L-Cysteic acid monohydrate \| L-Glutamine \| Direct Blue 1 \| L-Glutamic acid monosodium salt \| Piracetam \| O-Phospho-L-serine \| Memantine hydrochloride
Related Compound Libraries	Bioactive Compound Library \| Anti-Neurodegenerative Disease Compound Library \| Neuronal Signaling Compound Library \| Membrane Protein-targeted Compound Library \| Glutamine Metabolism Compound Library \| Drug Repurposing Compound Library \| Neuroprotective Compound Library \| Inhibitor Library \| FDA-Approved Drug Library \| Bioactive Compounds Library Max

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