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Clemizole hydrochloride

Basic information Safety Related Supplier
Clemizole hydrochloride Basic information
Clemizole hydrochloride Chemical Properties
  • Melting point:239-241°
  • storage temp. 2-8°C
  • solubility H2O: soluble2mg/mL, clear (warmed)
  • form powder
  • color white to beige
  • Merck 14,2346
  • InChIKeyDNFMJYXRIMLMBZ-UHFFFAOYSA-N
  • CAS DataBase Reference1163-36-6(CAS DataBase Reference)
Safety Information
  • Hazard Codes Xn
  • Risk Statements 22
  • Safety Statements 36
  • WGK Germany 3
  • RTECS DD6730000
MSDS
Clemizole hydrochloride Usage And Synthesis
  • UsesClemizole is an antihistamine that antagonizes the histamine 1 receptor at high nanomolar concentrations. It less potently blocks transient receptor potential canonical channel 5 (TRPC5; IC50 = 1.0-1.3 μM), with at least 6-fold selectivity for TRPC5 over other TRP channels. Clemizole also has hepatitis C antiviral action through inhibition of NS4B function, showing synergy with boceprevir , and it inhibits seizures in a zebrafish model of Dravet Syndrome.
Clemizole hydrochloride(1163-36-6)Related Product Information
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