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1163-36-6

供应商 相关产品 基本信息 物理化学性质 应用领域 安全数据 1-[(4-氯苯基)甲基]-2-(吡咯烷-1-基甲基)苯并咪唑盐酸盐价格(试剂级) 常见问题列表

产品图片

基本信息

中文
1-[(4-氯苯基)甲基]-2-(吡咯烷-1-基甲基)苯并咪唑盐酸盐
英文名称
1-[(4-Chlorophenyl)methyl]-2-(pyrrolidin-1-ylmethyl)benzoimidazole hydrochloride
1-P-CHLOROBENZYL-2-[1-PYRROLIDINYL]-METHYLBENZIMIDAZOLE HYDROCHLORIDE
CLEMIZOLE HCL
CLEMIZOLE HYDROCHLORIDE
LABOTEST-BB LT00453174
1-(p-chlorobenzil)-2-pirrolidil-metil-benzimidazolocloridato
1-(p-chlorobenzyl)-2-(1-pyrrolidinylmethyl)-benzimidazolmonohydrochloride
1-p-chlorobenzyl-pyrrolidyl-methylene-benzimidazolehydrochloride
allercur
allercurehydrochloride
p48
1-(4-Chlorophenyl)methyl)-2-(1-pyrrolidinylmethyl)-(1H)-benzimidazoleHCl
1-(P-CHLOROBENZYL)-2-(1-PYRROLIDINYLMETHYL)-BENZIMIDAZOL
CAS
1163-36-6
中文名称
1-[(4-氯苯基)甲基]-2-(吡咯烷-1-基甲基)苯并咪唑盐酸盐
盐酸氯咪唑
EINECS 编号
214-605-4
分子式
C19H21Cl2N3
MDL 编号
MFCD00051435
分子量
362.3
MOL 文件
1163-36-6.mol

物理化学性质

Merck 
13,2368

应用领域

用途一
用作氯咪唑青霉素等药物的中间体

安全数据

危险品标志 
Xn
危险类别码 
R22
安全说明 
S36
WGK Germany 
3

RTECS 
DD6730000

1-[(4-氯苯基)甲基]-2-(吡咯烷-1-基甲基)苯并咪唑盐酸盐价格(试剂级)

1-[(4-氯苯基)甲基]-2-(吡咯烷-1-基甲基)苯并咪唑盐酸盐价格(试剂级)
更新日期产品编号产品名称包装价格
2021/01/25C3468盐酸克立咪唑
Clemizole Hydrochloride
25mg1380元
2021/01/25C3468盐酸克立咪唑
Clemizole Hydrochloride
100mg3790元

常见问题列表

生物活性
Clemizole hydrochloride 是一种 H1 组胺受体 (H1 histamine receptor) 拮抗剂,抑制 HCV 复制。
靶点

IC50: 24 nM (NS4B)
H1 histamine receptor


体外研究

Clemizole hydrochloride is found to inhibit HCV RNA replication in cell culture that is mediated by its suppression of NS4B’s RNA binding, with little toxicity for the host cell. The EC 50 of Clemizole on the W55R mutant J6/JFH RNA is ~18 µM (2.25 times the EC 50 of the wild-type RNA). Clemizole is a novel inhibitor of TRPC5 channels. Clemizole efficiently blocks TRPC5 currents and Ca 2+ entry in the low micromolar range (IC 50 =1.0-1.3 µM). Clemizole exhibits a six-fold selectivity for TRPC5 over TRPC4β (IC 50 =6.4 µM), the closest structural relative of TRPC5, and an almost 10-fold selectivity over TRPC3 (IC 50 =9.1 µM) and TRPC6 (IC 50 =11.3 µM). Clemizole hydrochloride as a novel blocker of TRPC5 with a half-maximal inhibitory concentration of 1.1 µM. The concentration-response curves confirmed a concentration-dependent block of TRPC5 by Clemizole and revealed an apparent IC 50 of 1.1±0.04 µM.


体内研究

Clemizole hydrochloride has an unexpectedly short plasma half-life (measured at 0.15 hours); it is very rapidly biotransformed into a glucuronide (M14) and a dealkylated metabolite (M12) and into a variety of lesser metabolites in C57BL/6J mice.


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