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Clemizole hydrochloride

Clemizole hydrochloride Structure
Clemizole hydrochloride
  • CAS No.1163-36-6
  • Chemical Name:Clemizole hydrochloride
  • CBNumber:CB0484200
  • Molecular Formula:C19H21Cl2N3
  • Formula Weight:362.3
  • MOL File:1163-36-6.mol
Clemizole hydrochloride Property
  • Melting point: :239-241°
  • storage temp.  :2-8°C
  • solubility  :H2O: soluble2mg/mL, clear (warmed)
  • form  :powder
  • color  :white to beige
  • Merck  :14,2346
  • InChIKey :DNFMJYXRIMLMBZ-UHFFFAOYSA-N
  • CAS DataBase Reference :1163-36-6(CAS DataBase Reference)
  • FDA UNII :85W6I13D8M
Safety
  • Hazard Codes  :Xn
  • Risk Statements  :22
  • Safety Statements  :36
  • WGK Germany  :3
  • RTECS  :DD6730000
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordWarning
  • Hazard statements H302
  • Precautionary statements P301+P312+P330
Clemizole hydrochloride Price More Price(8)
  • Brand: Sigma-Aldrich
  • Product number: SML1447
  • Product name : Clemizole hydrochloride
  • Purity: ≥98% (HPLC)
  • Packaging: 5mg
  • Price: $83.7
  • Updated: 2021/03/22
  • Buy: Buy
  • Brand: Sigma-Aldrich
  • Product number: SML1447
  • Product name : Clemizole hydrochloride
  • Purity: ≥98% (HPLC)
  • Packaging: 25mg
  • Price: $338
  • Updated: 2021/03/22
  • Buy: Buy
  • Brand: TCI Chemical
  • Product number: C3468
  • Product name : Clemizole Hydrochloride
  • Purity: >98.0%(HPLC)
  • Packaging: 25mg
  • Price: $260
  • Updated: 2021/03/22
  • Buy: Buy
  • Brand: TCI Chemical
  • Product number: C3468
  • Product name : Clemizole Hydrochloride
  • Purity: >98.0%(HPLC)
  • Packaging: 100mg
  • Price: $715
  • Updated: 2021/03/22
  • Buy: Buy
  • Brand: Cayman Chemical
  • Product number: 17695
  • Product name : Clemizole (hydrochloride)
  • Purity: ≥98%
  • Packaging: 1mg
  • Price: $25
  • Updated: 2021/03/22
  • Buy: Buy

Clemizole hydrochloride Chemical Properties,Usage,Production

  • Originator Allercur,Roerig,US,1960
  • Uses Clemizole is an antihistamine that antagonizes the histamine 1 receptor at high nanomolar concentrations. It less potently blocks transient receptor potential canonical channel 5 (TRPC5; IC50 = 1.0-1.3 μM), with at least 6-fold selectivity for TRPC5 over other TRP channels. Clemizole also has hepatitis C antiviral action through inhibition of NS4B function, showing synergy with boceprevir , and it inhibits seizures in a zebrafish model of Dravet Syndrome.
  • Manufacturing Process From 13.1 g of N-p-chlorobenzyl-2-nitroaniline (MP 110°C, obtained in the form of orange-red needles, from o-nitrochlorobenzene and pchlorobenzylamine by reaction for 3 hours at 150°C) by reduction with Raneynickel and hydrogen, in which reaction the substance may be suspended in methanol or dissolved in methanol-ethyl acetate at normal pressure and at about 40°C with combination of the theoretical quantity of hydrogen, 12.2 g are obtained of o-amino-N-p-chlorobenzylaniline, which after recrystallization from aqueous methanol has a MP of 90°C.
    8 g of o-amino-N-p-chlorobenzylaniline and 2.8 g of pyridine are dissolved in dry ether and reacted with an ethereal solution of 3.9 g of chloracetyl chloride with cooling in a mixture of ice and common salt. 8 g of N-p-chlorobenzyl-N'- chloracetyl-o-phenylene diamine are obtained which can be worked up in the form of the crude product and, in the slightly colored form, has a MP of 130°C.
    7.6 g of this compound are boiled with 3.9 g of pyrrolidine in 70 cc of toluene for some hours under reflux. After extraction by shaking with water and treatment with hydrochloric acid the hydrochloride is produced of N-pchlorobenzyl-N'-pyrrolidylacetyl-o-phenylene diamine together with some 1-pchlorobenzyl-2-N-pyrrolidylmethyl-benzimidazole. The former, after recrystallization from butanol, melts with foaming at 205°C, the latter, after recrystallization from butanol melts at 239°C to 241°C, and is in the form of white microscopic rods. Boiling in nitrobenzene converts the former compound into the latter.
  • Therapeutic Function Antihistaminic
Clemizole hydrochloride Preparation Products And Raw materials
Raw materials
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1163-36-6, Clemizole hydrochlorideRelated Search:
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  • CS-1763
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  • 1H-BenziMidazole,1-[(4-chlorophenyl)Methyl]-2-(1-pyrrolidinylMethyl)-, hydrochloride (1:1)
  • 1-[(4-Chlorophenyl)methyl]-2-(pyrrolidin-1-ylmethyl)benzoimidazole hydrochloride Clemizole HCl
  • Clemizole hydrochloride 1-[(4-Chlorophenyl)methyl]-2-(pyrrolidin-1-ylmethyl)benzoimidazole hydrochloride
  • Clemizole hydrochloride, >=98%
  • 1-p-chlorobenzyl-pyrrolidyl-methylene-benzimidazolehydrochloride
  • 1-(p-chlorobenzil)-2-pirrolidil-metil-benzimidazolocloridato
  • 1-(p-chlorobenzyl)-2-(1-pyrrolidinylmethyl)-benzimidazolmonohydrochloride
  • 1-(4-Chlorobenzyl)-2-(pyrrolidin-1-ylmethyl)benzimidazole Hydrochloride
  • 1163-36-6
  • C19H21Cl2N3
  • C19H20ClN3HCl
  • C19H20ClN3ClH
  • Inhibitors