去氧肾上腺素碱
去氧肾上腺素碱 性质
| 熔点 | 171°C |
|---|---|
| 沸点 | 295.79°C (rough estimate) |
| 密度 | 1.1222 (rough estimate) |
| 折射率 | -55.5 ° (C=5, 1mol/L HCl) |
| 储存条件 | -20°C Freezer, Under inert atmosphere |
| 溶解度 | 微溶于水，微溶于甲醇，微溶于乙醇（96%）。它溶于稀无机酸和碱金属氢氧化物的稀溶液。 |
| 酸度系数(pKa) | pKa 8.9 (Uncertain) |
| 形态 | 固体 |
| 颜色 | 白色至类白色 |
| CAS 数据库 | 59-42-7(CAS DataBase Reference) |
| NIST化学物质信息 | Benzenemethanol, 3-hydroxy-«alpha»-[(methylamino)methyl]-, (r)-(59-42-7) |
去氧肾上腺素碱 用途与合成方法
(R)-(-)-Phenylephrine is a selective α 1 -adrenoceptor agonist with pK i values of 5.86, 4.87 and 4.70 for α 1D , α 1B and α 1A receptors respectively. Phenylephrine promotes cardiac fibroblast proliferation. Phenylephrine activates CaN and evokes NFAT3 nuclear translocation. It suggests that the Ca( 2+ )/CaN/NFAT pathway mediates phenylephrine -induced cardiac fibroblast proliferation, and this pathway might be a possible therapeutic target in cardiac fibrosis.
Perfusion of hearts with 100 μM phenylephrine causes a rapid (maximal at 10 min) 12-fold activation of two p38-MAPK isoforms. α 1 -adrenoceptor agonists such as phenylephrine increase the contractility of the heart. Phenylephrine also activates SAPKs/JNKs in neonatal ventricular myocytes. Phenylephrine could increase the alveolar fluid clearance in high tidal volume-ventilated rats and accelerate the absorption of pulmonary edema.
安全信息
| 危险品标志 | Xn |
|---|---|
| 危险类别码 | 22-36/37/38-41-37/38 |
| 安全说明 | 26-36-45-39 |
| RTECS号 | DO7175000 |
| 海关编码 | 2922.19.7000 |
| 毒害物质数据 | 59-42-7(Hazardous Substances Data) |
| 毒性 | LD50 oral in rat: 350mg/kg |
去氧肾上腺素碱 价格(试剂级)
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024-11-08 | HY-B0769 | 去氧肾上腺素碱 | 59-42-7 | 500mg | 500 |
| 2024-11-08 | P0395 | L-苯肾上腺素 | 59-42-7 | 5G | 720 |
