Basic information Chemical properties Uses What Is Lauric Acid? Including Lauric Acid in Your Diet Toxicity Usage limits Medium-Chain Triglycerides Production methods Safety Related Supplier
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Lauric acid

Basic information Chemical properties Uses What Is Lauric Acid? Including Lauric Acid in Your Diet Toxicity Usage limits Medium-Chain Triglycerides Production methods Safety Related Supplier
Lauric acid Basic information
Lauric acid Chemical Properties
  • Melting point:44-46 °C(lit.)
  • Boiling point:225 °C100 mm Hg(lit.)
  • Density 0.883 g/mL at 25 °C(lit.)
  • vapor pressure 1 mm Hg ( 121 °C)
  • FEMA 2614 | LAURIC ACID
  • refractive index 1.4304
  • Flash point:>230 °F
  • storage temp. Store below +30°C.
  • solubility 4.81mg/l
  • form Crystalline Powder of Flakes
  • pkapKa 4.92(H2O,t =25.0) (Uncertain)
  • color White
  • Specific Gravity0.883
  • explosive limit0.6%(V)
  • Water Solubility insoluble
  • λmax207nm(MeOH)(lit.)
  • JECFA Number111
  • Merck 14,5384
  • BRN 1099477
  • Stability:Stable. Combustible. Incompatible with bases, oxidizing agents, reducing agents.
  • InChIKeyPOULHZVOKOAJMA-UHFFFAOYSA-N
  • CAS DataBase Reference143-07-7(CAS DataBase Reference)
  • NIST Chemistry ReferenceDodecanoic acid(143-07-7)
  • EPA Substance Registry SystemLauric acid (143-07-7)
Safety Information
MSDS
Lauric acid Usage And Synthesis
  • Chemical propertiesColorless needle-like crystals. Soluble in methanol, slightly soluble in acetone and petroleum ether.
  • Uses1. lauric acid Used for the preparation of alkyd resins, as well as wetting agents, detergents and pesticides
    2. Used for peeling vegetables and fruits with a maximum amount of 3.0g/kg.
    3. Used as defoamer; GB 2760-86 provides for the spices allowed to use; used for the preparation of other food grade additives.
    4. lauric acid is widely used in the surfactant industry and can be, according to the classification of surfactants, divided into cationic, anionic, non-ionic and amphoteric type. The surfactants types of dodecanoic acid are listed in the attached table of this item. Some surfactants of the derivatives of dodecanoic acid and dodecanol are also antiseptics, such as dodecyl dimethyl benzyl ammonium chloride (geramine), dodecyl dimethyl benzyl ammonium bromide (bromo-geramine) and dodecyl dimethyl (2-phenoxyethyl) ammonium bromide (domiphen bromide). The dodecyldimethyllammonium-2,4,5-trichlorophenolate in these derivatives can be used as citrus preservative. Dodecanoic acid also has many applications in plastic additives, food additives, spices and pharmaceutical industries.
  • What Is Lauric Acid?Lauric acid is a medium-length long-chain fatty acid, or lipid, that makes up about half of the fatty acids within coconut oil. It’s a powerful substance that is sometimes extracted from the coconut for use in developing monolaurin. Monolaurin is an antimicrobial agent that is able to fight bacteria, viruses, yeasts, and other pathogens. Because you can’t ingest lauric acid alone (it’s irritating and not found alone in nature), you’re most likely to get it in the form of coconut oil or from fresh coconuts.
    Though coconut oil is being studied at a breakneck pace, much of the research doesn’t pinpoint what in the oil is responsible for its reported benefits. Because coconut oil contains much more than just lauric acid, it would be a stretch to credit it with all of the coconut oil benefits. Still, a 2015 analysis suggests that many of the benefits tied to coconut oil are directly linked to lauric acid. Among the benefits, they suggest lauric acid could aid weight loss and even protect against Alzheimer’s disease. Its effects on blood cholesterol levels still need to be clarified.
    This research suggests that the benefits of lauric acid are due to how the body uses it. The majority of lauric acid is sent directly to the liver, where it’s converted to energy rather than stored as fat. When compared with other saturated fats, lauric acid contributes the least to fat storage.
  • Including Lauric Acid in Your DietLauric acid can be taken as a supplement, but it is most commonly consumed as part of coconut oil or palm kernel oil. It is considered to be safe based on the amounts generally found in food. According to NYU Langone Medical Center, coconut and palm kernel oil contain up to 15 percent MCTs, along with a number of other fats. However, because they are still pure oil, limit your intake of MCTs to stay within the recommended 5 to 7 teaspoons of oil per day as set out by the U.S. Department of Agriculture. You can use coconut and palm kernel oil for stir-fries because both oils withstand high heat. They can also be used in baking, adding a natural richness to your food.
  • ToxicityNatural fatty acids, non-toxic.
    Safe for use in food products (FDA, §172.860, 2000).
    LD50 12 g/kg (rat, oral).
  • Usage limitsFEMA (mg/kg): soft drinks 15, cold drinks 16, candy 2.4, baked food 39, pudding class 25, oil 315.
    GB 2760-1996: fruit and vegetable peeling 3.0g/kg.
  • Medium-Chain TriglyceridesMedium-chain triglycerides, or fatty acids, such as lauric acid, are characterized by a specific chemical structure that allows your body to absorb them whole. This makes them more easily digestible--your body processes them as it would carbohydrates, and they are used as a source of direct energy. Compared to long-chain triglycerides, the type in other saturated fats, MCTs have fewer calories per serving, roughly 8.3 calories per gram rather than the standard 9 calories per gram, according to an article in "Nutrition Review."
  • Production methods1. Industrial production methods can be grouped into two categories: 1) derived from the saponification or high temperature and pressure decomposition of natural vegetable oils and fats; 2) separated from the synthetic fatty acid. Japan mainly uses coconut oil and palm kernel oil as the raw materials for the preparation of lauric acid. The natural vegetable oils used to produce dodecanoic acid include coconut oil, litsea cubeba kernel oil, palm kernel oil and mountain pepper seed oil. Other plants oil, such as palm kernel oil, tea tree seed oil and camphor tree seed oil, can also service industry to produce dodecanoic acid. The residual C12 distillate from the extraction of dodecanoic acid, containing a large number of dodecenoic acid, can be hydrogenated at atmospheric pressure, without catalyst, to convert into dodecanoic acid with a yield of more than 86%.
    2. Derived from the separation and purification of coconut oil and other vegetable oil.
    3. Lauric acid naturally exists in coconut oil, litsea cubeba kernel oil, palm kernel oil and pepper kernel oil in the form of glyceride. It can be derived from the hydrolysis of natural oils and fats in industry. The coconut oil, water and catalyst are added into the autoclave and hydrolyzed to glycerol and fatty acid at 250 ℃ under the pressure of 5MPa. The content of dodecanoic acid is 45%~80%, and can be further distilled to obtain dodecanoic acid.
  • DescriptionLauric acid ( systematically: dodecanoic acid ), the saturated fatty acid with a 12-carbon atom chain, thus falling into the medium chain fatty acids, is a white, powdery solid with a faint odor of bay oil or soap.
  • Chemical PropertiesLike many other fatty acids, lauric acid is inexpensive, has a long shelf-life, and is non-toxic and safe to handle. It is mainly used for the production of soaps and cosmetics. For these purposes, lauric acid is neutralized with sodium hydroxide to give sodium laurate, which is a soap. Most commonly, sodium laurate is obtained by saponification of various oils, such as coconut oil. These precursors give mixtures of sodium laurate and other soaps.
  • Chemical PropertiesLauric acid occurs as a white crystalline powder with a slight odor of bay oil.
  • Chemical Propertieswhite solid with a faint odour of bay oil
  • Chemical PropertiesLaurie acid has a fatty odor.
  • Chemical PropertiesLauric acid has a fatty odor. It is a common constituent of most diets; large doses may produce gastrointestinal upset
  • OccurrenceLauric acid, as a component of triglycerides, comprises about half of the fatty acid content in coconut oil, laurel oil, and in palm kernel oil (not to be confused with palm oil) , Otherwise it is relatively uncommon. It is also found in human breast milk ( 6.2 % of total fat), cow's milk (2.9%), and goat's milk (3.1 %).
  • UsesIntermediates of Liquid Crystals
  • UsesGiven its foaming properties, the derivatives of lauric acid (h-dodecanoic acid) are widely used as a base in the manufacture of soaps, detergents, and lauryl alcohol. Lauric acid is a common constituent of vegetable fats, especially coconut oil and laurel oil. It may have a synergistic effect in a formula to help fight against mircoorganisms. It is a mild irritant but not a sensitizer, and some sources cite it as comedogenic.
  • UsesLauric Acid is a fatty acid obtained from coconut oil and other veg- etable fats. it is practically insoluble in water but is soluble in alco- hol, chloroform, and ether. it functions as a lubricant, binder, and defoaming agent.
  • DefinitionChEBI: A straight-chain, twelve-carbon medium-chain saturated fatty acid with strong bactericidal properties; the main fatty acid in coconut oil and palm kernel oil.
  • Production MethodsLauric acid is a fatty carboxylic acid isolated from vegetable and animal fats or oils. For example, coconut oil and palm kernel oil both contain high proportions of lauric acid. Isolation from natural fats and oils involves hydrolysis, separation of the fatty acids, hydrogenation to convert unsaturated fatty acids to saturated acids, and finally distillation of the specific fatty acid of interest.
  • DefinitionA white crystalline carboxylic acid, used as a plasticizer and for making detergents and soaps. Its glycerides occur naturally in coconut and palm oils.
  • Aroma threshold valuesAroma characteristics at 1.0%: fatty, creamy, cheeselike, candle waxy with egglike richness
  • Taste threshold valuesTaste characteristics at 5 ppm: waxy,fatty and oily, tallowlike, creamy and dairylike with a coating mouthfeel
  • General DescriptionWhite solid with a slight odor of bay oil.
  • Air & Water ReactionsInsoluble in water.
  • Reactivity ProfileLauric acid is a carboxylic acid. Carboxylic acids donate hydrogen ions if a base is present to accept them. They react in this way with all bases, both organic (for example, the amines) and inorganic. Their reactions with bases, called "neutralizations", are accompanied by the evolution of substantial amounts of heat. Neutralization between an acid and a base produces water plus a salt. Carboxylic acids in aqueous solution and liquid or molten carboxylic acids can react with active metals to form gaseous hydrogen and a metal salt. Such reactions occur in principle for solid carboxylic acids as well, but are slow if the solid acid remains dry. Even "insoluble" carboxylic acids may absorb enough water from the air and dissolve sufficiently in Lauric acid to corrode or dissolve iron, steel, and aluminum parts and containers. Carboxylic acids, like other acids, react with cyanide salts to generate gaseous hydrogen cyanide. The reaction is slower for dry, solid carboxylic acids. Insoluble carboxylic acids react with solutions of cyanides to cause the release of gaseous hydrogen cyanide. Flammable and/or toxic gases and heat are generated by the reaction of carboxylic acids with diazo compounds, dithiocarbamates, isocyanates, mercaptans, nitrides, and sulfides. Carboxylic acids, especially in aqueous solution, also react with sulfites, nitrites, thiosulfates (to give H2S and SO3), dithionites (SO2), to generate flammable and/or toxic gases and heat. Their reaction with carbonates and bicarbonates generates a harmless gas (carbon dioxide) but still heat. Like other organic compounds, carboxylic acids can be oxidized by strong oxidizing agents and reduced by strong reducing agents. These reactions generate heat. A wide variety of products is possible. Like other acids, carboxylic acids may initiate polymerization reactions; like other acids, they often catalyze (increase the rate of) chemical reactions. Lauric acid can react with oxidizing materials.
  • Health HazardMay be harmful by inhalation, ingestion or skin absorption. Vapor or mist is irritating to eyes, mucous membrane and upper respiratory tract. Causes eye and skin irritation.
  • Fire HazardBehavior in Fire: May cause dust explosion.
  • Pharmaceutical Applicationspharmaceutical applications it has also been examined for use as an enhancer for topical penetration and transdermal absorption, rectal absorption, buccal delivery,(14) and intestinal absorption. It is also useful for stabilizing oil-in-water emulsions. Lauric acid has also been evaluated for use in aerosol formulations.
  • SafetyLauric acid is widely used in cosmetic preparations, in the manufacture of food-grade additives, and in pharmaceutical formulations. General exposure to lauric acid occurs through the consumption of food and through dermal contact with cosmetics, soaps, and detergent products. Lauric acid is toxic when administered intravenously.
    Occupational exposure may cause local irritation of eyes, nose, throat, and respiratory tract, although lauric acid is considered safe and nonirritating for use in cosmetics. No toxicological effects were observed when lauric acid was administered to rats at 35% of the diet for 2 years. Acute exposure tests in rabbits indicate mild irritation. After subcutaneous injection into mice, lauric acid was shown to be noncarcinogenic.
    LD50 (mouse, IV): 0.13 g/kg
    LD50 (rat, oral): 12 g/kg
  • Chemical SynthesisProduced from synthetic lauryl alcohol
  • CarcinogenicityLauric acid was not carcinogenic in the BALB/c:CFW mouse after repeated subcutaneous injections. Lauric acid applied twice weekly for 20 weeks did not promote tumors in mice initiated with 9,10- dimethyl-1,2-benzanthracene. After more extended application (daily, 6 days/week, for 31 weeks), lauric acid caused an increase in skin papillomas, but no histologically malignant tumors were found. Lauric acid was not carcinogenic in rats after exposure in the diet to 35% lauric acid for 2 years.
  • storageLauric acid is stable at normal temperatures and should be stored in a cool, dry place. Avoid sources of ignition and contact with incompatible materials.
  • Purification MethodsDistil the acid in a vacuum. Also crystallise it from absolute EtOH, or from acetone at -25o. Alternatively, purify it via its methyl ester (b 140.0o/15mm), as described for capric acid. It has also been purified by zone melting. [cf Beilstein 1 III 2913.]
  • IncompatibilitiesLauric acid is incompatible with strong bases, reducing agents, and oxidizing agents.
  • Regulatory StatusGRAS listed. Lauric acid is listed as a food additive in the EAFUS list compiled by the FDA. Reported in the EPA TSCA Inventory.
Lauric acid Preparation Products And Raw materials
Lauric acid(143-07-7)Related Product Information
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