Vitamine D3

Product NameVitamine D3
CAS67-97-0
MFC27H44O
MW384.64
EINECS200-673-2
MOL File67-97-0.mol

Chemical Properties

Melting point	83-86 °C(lit.)
alpha	105 º (c=0.8, EtOH 25 ºC)
Boiling point	451.27°C (rough estimate)
Density	0.9717 (rough estimate)
vapor pressure	2.0 x l0^-6 Pa (20 °C, est.)
refractive index	1.5100 (estimate)
Flash point	14 °C
storage temp.	-20°C
solubility	Practically insoluble in water, freely soluble in ethanol (96 per cent), soluble in trimethylpentane and in fatty oils. It is sensitive to air, heat and light. Solutions in solvents without an antioxidant are unstable and are to be used immediately. A reversible isomerisation to pre-cholecalciferol takes place in solution, depending on temperature and time. The activity is due to both compounds.
pka	14.74±0.20(Predicted)
form	powder
color	White
Odor	odorless
Water Solubility	<0.1 g/L (20 ºC)
Sensitive	Air & Light Sensitive
Merck	14,10019
BRN	2339331
Stability	Light Sensitive, Temperature Sensitive
InChIKey	QYSXJUFSXHHAJI-YRZJJWOYSA-N
LogP	9.085 (est)
CAS DataBase Reference	67-97-0(CAS DataBase Reference)
NIST Chemistry Reference	Cholecalciferol(67-97-0)
EPA Substance Registry System	Cholecalciferol (67-97-0)

Safety Information

Hazard Codes	Xn,T
Risk Statements	26-24/25 -48/25
Safety Statements	28-45-36/37
WGK Germany	2
RTECS	VS2900000
F	8-10-23
TSCA	Yes
HS Code	29362990
Hazardous Substances Data	67-97-0(Hazardous Substances Data)
Toxicity	LD50 oral in rat: 42mg/kg

MSDS

Provider	Language
9,10-Secocholesta-5,7,10(19)-trien-3beta-ol	English
SigmaAldrich	English
ACROS	English
ALFA	English

Usage And Synthesis

Description

Vitamine D3 is a fat-soluble vitamin that helps your body absorb calcium and phosphorus. Having the right amount of vitamin D3, calcium, and phosphorus is important for building and keeping strong bones.

Vitamine D3.png

Uses

Vitamin D3 is used to treat and prevent bone disorders (such as rickets, osteomalacia). Vitamin D3 with calcium is used to treat or prevent bone loss (osteoporosis). Vitamin D3 is also used with other medications to treat low levels of calcium or phosphate caused by certain disorders (such as hypoparathyroidism, pseudohypoparathyroidism, familial hypophosphatemia).

benefits

Vitamin D3 (cholecalciferol) has a few health benefits, including helping the body absorb calcium.Vitamin D3, through its active metabolite, 1,25- (OH)2D3, also plays an important role in maintaining calcium homeostasis by enhancing intestinal calcium absorption, PTH-induced mobilization of calcium from bone, and calcium reabsorption in the kidney.

Usage

Vitamin D3 is a fat-soluble vitamin. This means that taking it with fat helps it absorb better. It doesn’t matter what time of day you take it, but you should eat fat-containing food when you do.

Side effects

Stomach upset

Nausea

Vomiting

Constipation

Bone pain

Muscle weakness

An increased risk of bone fractures

Toxicity

Vitamin D3 is generally regarded as safe, but it can on rare occasions cause toxic effects if you take too much. This is referred to as hypervitaminosis D.With vitamin D toxicity, the balance of minerals like calcium and potassium is upset. This can lead to a condition known as hypercalcemia, in which too much calcium builds up in the body.

Source

Foods such as fish, beef liver, eggs, and cheese naturally contain vitamin D3. It can also be produced in the skin following exposure to ultraviolet (UV) radiation from the sun.