Benzamidine Hcl

Benzamidine is a drug used to treat painful and inflammatory conditions of the oral cavity, such as infections and gingivitis.

Benzamidine HCl is a reversible inhibitor of trypsin, trypsin-like enzymes, and serine proteases. A concentration of approximately 1 mM is used for general protease inhibition. To inhibit proteases from yeast, a range of 0.5 to 4.0 mM is used and it is for the most part interchangeable with pepstatin A.

Benzamidine hydrochloride (50 μM) reduces [3H]thymidine incorporation in fibroblasts, suggesting dependency on an active catalytic site. Benzamidine hydrochloride reduces the ability of tryptase to stimulate collagen synthesis.