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Berberine hydrochloride

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Berberine hydrochloride Basic information
Berberine hydrochloride Chemical Properties
  • Melting point:204-206 °C (dec.)
  • storage temp. +2C to +8C
  • solubility methanol: soluble
  • form Yellow powder
  • Colour Index  75160
  • color Yellow powder
  • Water Solubility SOLUBLE IN COLD WATER
  • BRN 3836585
  • InChIKeyVKJGBAJNNALVAV-UHFFFAOYSA-M
  • CAS DataBase Reference633-65-8
  • EPA Substance Registry SystemBerberine chloride (633-65-8)
Safety Information
  • Hazard Codes Xn
  • Risk Statements 20/21/22-36/37/38
  • Safety Statements 24/25-36-26
  • RIDADR 1544
  • WGK Germany 2
  • RTECS DR9866400
  • 3-10
  • TSCA Yes
  • HazardClass 6.1(b)
  • PackingGroup III
  • HS Code 29349990
  • ToxicityLD50 orl-rat: >15 g/kg KSRNAM 8,654,74
MSDS
Berberine hydrochloride Usage And Synthesis
  • Chemical Propertiesyellow crystalline powder
  • Usesantiarrhythmic, alpha2 agonist, anticonvulsant, antiinflammatory, antibacterial, antifungal, antitrypanosomal, antineoplastic, immunostimulant
  • UsesAn isoqinoline alkaloid shown to have a chemopreventive property against colon tumor formation by inhibiting the enzyme cyclooxygenase-2 (cox-2) which is abundantly expressed in colon cancer cells. Al so inhibits Activator Protein 1 (AP-1), a transcription factor that plays a critical role in inflammation and carcinogenesis. Treatment with berberine potentially results in the reduced accumulation o f chemotherapeutic drugs.
  • UsesAn ingredient in some commercial eyewash products.
  • Safety ProfilePoison by intraperitoneal route.Slightly toxic by ingestion. Mutation data reported. Whenheated to decomposition it emits toxic vapors of NOx andCl-.
  • Purification MethodsBerberine chloride crystallises from water to give the dihydrate. The anhydrous salt may be obtained by recrystallisation from EtOH/Et2O, wash the crystals with Et2O and dry them in a vacuum. The iodide has m 250o(dec) (from EtOH). [Perkin J Chem Soc 113 503 1918, Kametani et al. J Chem Soc(C) 2036 1969, Beilstein 27 I 515, 27 II 567.]
Berberine hydrochloride(633-65-8)Related Product Information
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