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Daunorubicin hydrochloride

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Daunorubicin hydrochloride Basic information
Daunorubicin hydrochloride Chemical Properties
  • Melting point:190°C (dec)
  • alpha D20 +248 ±5° (c = 0.05-0.1 in methanol)
  • storage temp. −20°C
  • solubility Freely soluble in water and in methanol, slightly soluble in alcohol, practically insoluble in acetone.
  • form solid
  • color red to deep red
  • Sensitive Hygroscopic
  • λmax477nm(H2O)(lit.)
  • Merck 14,2832
  • BRN 4229221
  • Stability:Stability
  • EPA Substance Registry SystemDaunorubicin hydrochloride (23541-50-6)
Safety Information
MSDS
Daunorubicin hydrochloride Usage And Synthesis
  • Chemical PropertiesDark Red Crystals
  • UsesAntineoplastic;DNA intercaling
  • Usesanti-neoplastic LD50 in mice 26 mg/kg
  • UsesA DNA intercalator which may suppress acute leukemia proliferation
  • UsesAnthracycline antibiotic related to the rhodomycins. Antineoplastic
  • brand nameCerubidine (Bedford); Cerubidine (Sanofi Aventis); Cerubidine (Wyeth).
  • General DescriptionDaunorubicin is available in 20- and 100-mg vials for reconstitution.The agent is given intravenously for the treatmentof acute nonlymphocytic and lymphocytic leukemia. Otherunlabeled uses include CML and Kaposi sarcoma. In general,its use is more limited than that of doxorubicin.Daunorubicin lacks the hydroxyl groups found at C-14 ofdoxorubicin. This leads to an increase in the amount of thealcohol metabolite daunorubicinol (active) arising as a resultof reduction of the side chain ketone. This, however, doesnot appear to lead to a significant increase in the occurrenceof cardiotoxicity compared with doxorubicin. The mechanismsof resistance and toxicities of daunorubicin are similarto that of doxorubicin; the major difference betweenthe two agents being the spectrum of cancers that they areused treat.
    A liposomal form of daunorubicin is also availableknown as DaunoXome. The drug offers the same advantagesas those seen for the liposomal form of doxorubicin.
  • General DescriptionOrange-red powder. Thin red needles decomposing at 188-190°C. An anti-cancer drug.
  • Air & Water ReactionsWater soluble.
  • Reactivity ProfileDaunorubicin hydrochloride may emit toxic oxides of nitrogen when heated.
  • Biological ActivityAnticancer agent that is clinically used to treat nonlymphocytic leukaemia. Inhibits RNA and DNA synthesis and causes DNA fragmentation in vivo .
Daunorubicin hydrochloride Preparation Products And Raw materials
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