コバマミド

危険有害性情報のコード(GHS)

• 絵表示(GHS)

  

• 注意喚起語

  Warning

• 危険有害性情報

  H302：飲み込むと有害

  H315：皮膚刺激

  H319：強い眼刺激

  H335：呼吸器への刺激のおそれ

• 注意書き

  P261：粉じん/煙/ガス/ミスト/蒸気/スプレーの吸入を避ける こと。

  P305+P351+P338：眼に入った場合：水で数分間注意深く洗うこと。次にコ ンタクトレンズを着用していて容易に外せる場合は外す こと。その後も洗浄を続けること。

コバマミド 価格

コバマミド 化学特性,用途語,生産方法

• 性質

  平らなダイヤモンド型赤色晶．λmax 260 nm (ε 34700)，340 nm (ε 12300), 375 nm (ε 10900)，522nm (ε 8000)．冷暗所安定．室温光分解．水溶液はpH 6～7でもっとも安定．急速に光分解．加熱徐々に不活性化

• 生物学的性質

  CoがC原子に結合し異性化，基転移反応を起こす．メチルマロニル CoA ムターゼ，1,2-プロパンジオールデヒドラターゼなどの補酵素．N5-メチルテトラヒドロ葉酸によるホモシステインのメチル化の補酵素でもある

• 効能

  貧血治療薬, ビタミンB12補充薬

• 商品名

  コバマミド (鶴原製薬); ハイコバール (エーザイ)

• 説明

  Coenzyme B12 (adenosylcobalamin; AdoCbl; 5'-Deoxyadenosylcobalamin) is a form of vitamin B12. It belongs to the corrinoid group of compounds containing a corrin macrocycle and are produced only by certain bacteria and archaea. It is a cofactor for various enzymes, including mutases, eliminases, aminomutases, and reductases. These enzymes catalyze reactions that generate free radicals through the release of the adenosyl group, allowing usually unreactive molecules to become reactive. Genetic mutations in enzymes synthesizing Coenzyme B12 lead to Coenzyme B12 deficiency and methylmalonic aciduria.

• 分布

  Propionibacteria，Clostridia，酵母から抽出

• 使用

  emulsifying agent

• 定義

  ChEBI: A member of the class of cobalamins that is vitamin B12 in which the cyano group is replaced by a 5'-deoxyadenos-5'-yl moiety. It is one of the two metabolically active form of vitamin B12.

• 一般的な説明

  Vitamin B₁₂ cobalamin refers to a group of chemically-related cobalt containing molecules. The physiologically active forms of vitamin B₁₂ include methylcobalamin and adenosylcobalamin, whereas hydroxocobalamin (vitamin B_12a, OHCbl) and cyanocobalamin (CNCbl) are storage and delivery forms.

• 农业用途

  Cobamide enzyme is the cobalt complex formed between the cobalt-porphyrin ring structure and the nucleotide in vitamin B₁₂ co-enzyme.

• 参考文献

  [1] Thuan Phu Nguyen-Vo. “Analysis and characterization of coenzyme B12 biosynthetic gene clusters and improvement of B12 biosynthesis in Pseudomonas denitrificans ATCC 13867.” Fems Microbiology Letters 365 21 (2018).
  [2] I. I. Merkelbach, Hm Henk Buck. “Mechanism of action of coenzyme B12. Quantum-chemical considerations.” Recueil des Travaux Chimiques des Pays-Bas 28 1 (2010): 166–169.
  [3] Prof. Dr. Karl Gruber, Prof. Dr. Bernhard Krutler. “Coenzyme B12 Repurposed for Photoregulation of Gene Expression.” Angewandte Chemie International Edition 55 19 (2016): 5638–5640.

コバマミド 上流と下流の製品情報

コバマミド 生産企業

Global(260)Suppliers

13870-90-1, コバマミド キーワード