ステアリン酸

危険有害性情報のコード(GHS)

• 絵表示(GHS)

  

• 注意喚起語

  Warning

• 危険有害性情報

  H315：皮膚刺激

  H319：強い眼刺激

  H335：呼吸器への刺激のおそれ

• 注意書き

  P261：粉じん/煙/ガス/ミスト/蒸気/スプレーの吸入を避ける こと。

  P304+P340：吸入した場合：空気の新鮮な場所に移し、呼吸しやすい 姿勢で休息させること。

  P305+P351+P338：眼に入った場合：水で数分間注意深く洗うこと。次にコ ンタクトレンズを着用していて容易に外せる場合は外す こと。その後も洗浄を続けること。

  P405：施錠して保管すること。

ステアリン酸 価格

MSDS Information

• Stearic acid

ステアリン酸 化学特性,用途語,生産方法

• 外観

  白色の粒状

• 定義

  本品は、次の化学式で表される脂肪酸である。

• 溶解性

  水に不溶。エタノールに可溶。エーテルに易溶。ジエチルエーテルに溶けやすく、エタノールにやや溶けやすく、水にほとんど溶けない。

• 解説

  ステアリン酸．代表的飽和脂肪酸で，グリセリドとして天然油脂中，とくに牛脂に多く含まれ，そのほか多くの動物，植物油中に存在する．無色の葉状結晶．融点69～70 ℃，沸点383 ℃(分解)，232 ℃(2 kPa)．d²⁰₄ 0.9408．n⁸⁰_D 1.4299．エタノールに可溶，ベンゼン，二硫化炭素に難溶．せっけん，界面活性剤など多方面に利用される．グリセリドを構成するさまざまの脂肪酸のなかの主要成分であり、とくにウシやヒツジの脂肪（固体）に含量が高く、植物油（液体）にはほとんどみいだされない。せっけんは油脂をカ性ソーダでけん化してつくるので、その主成分はステアリン酸のナトリウム塩である。また、オレイン酸の水素添加反応によってステアリン酸が得られる。ステアリン酸とパルミチン酸との混合物は、ろうそく、軟膏(なんこう)、化粧用クリームなどの原料として広く用いられる。

• 用途

  石けん、金属石けん、表面活性剤、ロウソク、研摩剤、絶縁剤の製造原料、ゴム工業において加硫促進剤の助剤、その他軟化剤、カーボンブラックの分散剤、またカルシウムの比ロウ分析用試薬として用いられる。ステアリン酸カルシウムのコロイド状沈殿を利用し、カルシウムを比ロウ分析することができ、ミルク、血液、尿中のカルシウムの定量に利用される。

• 化粧品の成分用途

  乳化剤、洗浄剤、香料

• 効能

  乳化補助剤, 錠・カプセル潤滑剤

• 説明

  Stearic acid (STAIR-ik or STEER-ik) is the saturated fatty acid with an 18 carbon chain and has the IUPAC name octadecanoic acid. It is a waxy solid, and its chemical formula is CH₃(CH₂)₁₆CO₂H. Its name comes from the Greek word στ?αρ "stéar", which means tallow. The salts and esters of stearic acid are called stearates. Stearic acid is one of the most common saturated fatty acids found in nature following palmitic acid.

• 化学的特性

  Stearic acid, CH3(CH2)16COOH, is a white or colorless, waxlike solid with a melting point of 70°C (158 OF), and a boiling point of 232°C (450 OF) at 2 kPa. It is soluble in alcohol, ether, and chloroform,and is insolublein water. Stearic acid, nature's most common fatty acid, is derived from natural animal and vegetable fats. Also known as n-octadecanoic acid, stearic acid is used in the preparation of metallic stearates, as a lubricant, and in pharmaceuticals, cosmetics, candles, and food packaging.

• 天然物の起源

  Stearic acid is naturally present in the glycerides of animal fats and most vegetable oils. Reported found in fresh apple, banana, Vitis vinifera L., melon, tomato, ginger, blue cheeses, cheddar cheese, Swiss cheese, feta cheese, buttermilk, raw fatty fish, raw lean fish, raw shrimp, grapefruit juice, guava, papaya, cucumber, saffron, pork and lamb liver, pork fat, hop oil, beer, cognac, rum, whiskies, sherry, tea, peanut oil, soybean, roast coconut, coconut milk, avocado, passion fruit, rose apple, mushroom, starfruit, fenugreek, mango, cardamom, cooked rice, prickly pear, dill seed, buckwheat, malt, wort, cassava, loquat, shrimp, crab, cape gooseberry and Chinese quince.

• 使用

  stearic acid is an emulsifier and thickening agent found in many vegetable fats. Stearic acid is the main ingredient used in making bar soaps and lubricants. It occurs naturally in butter acids, tallow, cascarilla bark, and in other animal fats and oils. Stearic acid may cause allergic reactions in people with sensitive skin and is considered somewhat comedogenic.

• 定義

  ChEBI: A C18 straight-chain saturated fatty acid component of many animal and vegetable lipids. As well as in the diet, it is used in hardening soaps, softening plastics and in making cosmetics, candles and plastics.

• 製造方法

  Commercially it is produced by the hydrogenation of the unsaturated 18-carbon fatty acids of soybean, cottonseed or other vegetable oils. When obtained from animal fats by hydrolysis and fractional crystallization, commercial stearic acid is a mixture of solid organic acids, chiefly palmitic and stearic acids. Commercial products containing about 90% stearic acid are produced by hydrolysis and crystallization of a completely hydrogenated vegetable oil or by fractional distillation of fatty acid mixtures obtained from tallow

• 調製方法

  Stearic acid is manufactured by hydrolysis of fat by continuous exposure to a countercurrent stream of high-temperature water and fat in a high-pressure chamber. The resultant mixture is purified by vacuum steam distillation and the distillates are then separated using selective solvents.
  Stearic acid may also be manufactured by the hydrogenation of cottonseed and other vegetable oils; by the hydrogenation and subsequent saponification of olein followed by recrystallization from alcohol; and from edible fats and oils by boiling with sodium hydroxide, separating any glycerin, and decomposing the resulting soap with sulfuric or hydrochloric acid. The stearic acid is then subsequently separated from any oleic acid by cold expression.
  Stearic acid is derived from edible fat sources unless it is intended for external use, in which case nonedible fat sources may be used. The USP32–NF27 states that stearic acid labeled solely for external use is exempt from the requirement that it be prepared from edible sources. Stearic acid may contain a suitable antioxidant such as 0.005% w/w butylated hydroxytoluene.

• 一般的な説明

  White solid with a mild odor. Floats on water.

• 空気と水の反応

  Slightly soluble in water.

• 反応プロフィール

  Stearic acid is incompatible with strong oxidizers and strong bases. Stearic acid is also incompatible with reducing agents.

• 健康ハザード

  Compound is generally considered nontoxic. Inhalation of dust irritates nose and throat. Dust causes mild irritation of eyes.

• 火災危険

  Stearic acid is combustible. Stearic acid can heat spontaneously.

• 応用例（製薬）

  Stearic acid is widely used in oral and topical pharmaceutical formulations. It is mainly used in oral formulations as a tablet and capsule lubricant, although it may also be used as a binder or in combination with shellac as a tablet coating. It has also been suggested that stearic acid may be used in enteric tablet coatings and as a sustained-release drug carrier.
  In topical formulations, stearic acid is used as an emulsifying and solubilizing agent. When partially neutralized with alkalis or triethanolamine, stearic acid is used in the preparation of creams. The partially neutralized stearic acid forms a creamy base when mixed with 5–15 times its own weight of aqueous liquid, the appearance and plasticity of the cream being determined by the proportion of alkali used.
  Stearic acid is used as the hardening agent in glycerin suppositories.
  Stearic acid is also widely used in cosmetics and food products.

• 安全性プロファイル

  Poison by intravenous route. A human sktn irritant. Questionable carcinogen with experimental tumorigenic data by implantation route. Combustible when exposed to heat or flame. Heats spontaneously. To fight fire, use CO2, dry chemical. When heated to decomposition it emits acrid smoke and irritating fumes.

• 安全性

  Stearic acid is widely used in oral and topical pharmaceutical formulations; it is also used in cosmetics and food products. Stearic acid is generally regarded as a nontoxic and nonirritant material. However, consumption of excessive amounts may be harmful.
  LD50 (mouse, IV): 23 mg/kg
  LD50 (rat, IV): 21.5 mg/kg

• 発がん性

  Stearic acid was administered subcutaneously to several groups of Swiss–Webster mice at doses of 0.05 or 0.5mg once weekly for 25 weeks (total dose of 1.3–130 mg), 1.0 mg thrice a week for a total of 10 injections or 1.0 mg twice weekly for a total of 82 injections. No neoplasms were reported in these studies . In 3 groups of 10–15 BALB/c mice administered 0.05 mg or 0.5 mg stearic acid (twice weekly for 52 or 57 weeks), one pulmonary neoplasm was detected in each group after 19–21 months.Afewsubcutaneous sarcomas and one adrenal carcinoma were also reported.No injection site sarcomas or other carcinogenic effects were reported by the same authors in a later study of mice injected with 0.05–0.5 mg weekly for 26 weeks. Rats given subcutaneous injections of 0.05 or 0.5 mg stearic acid weekly for 26 weeks did not develop sarcomas at the site of injection. When rat fibroblast cells were transfected with an activated human c-H-ras oncogene and the cells subsequently grown in a medium supplemented with stearic acid (20–80 mM), there was a marked increase in the number of transformed foci. Stearic acid inhibited the colony-forming ability of four out of five rat and two human tumor continuous cell lines in vitro. Using rats pretreated with nitrosomethyl urea as a model for mammary carcinoma, Habib et al. demonstrated that subcutaneous injection of stearic acid at weekly intervals prevented tumor development. Increasing levels of stearate in the diet resulted in decreased mammary tumor incidence and increased time to tumor in mice.

• 代謝

  An isotope labeling study in humans concluded that the fraction of dietary stearic acid oxidatively desaturated to oleic acid was 2.4 times higher than the fraction of palmitic acid analogously converted to palmitoleic acid. Also, stearic acid was less likely to be incorporated into cholesterol esters. In epidemiologic and clinical studies stearic acid was associated with lowered LDL cholesterol in comparison with other saturated fatty acids. These findings may indicate that stearic acid is healthier than other saturated fatty acids.

• 貯蔵

  Stearic acid is a stable material; an antioxidant may also be added to it. The bulk material should be stored in a wellclosed container in a cool, dry place.

• 純化方法

  Crystallise stearic acid from acetone, acetonitrile, EtOH (5 times), aqueous MeOH, ethyl methyl ketone or pet ether (b 60-90o), or by fractional precipitation by dissolving in hot 95% EtOH and pouring into distilled water, with stirring. The precipitate, after washing with distilled water, is dried under vacuum over P2O5. It has also been purified by zone melting and partial freezing. [Tamai et al. J Phys Chem 91 541 1987, Beilstein 2 IV 1206.]

• 不和合性

  Stearic acid is incompatible with most metal hydroxides and may be incompatible with bases, reducing agents, and oxidizing agents.
  Ointment bases made with stearic acid may show evidence of drying out or lumpiness due to such a reaction when compounded with zinc or calcium salts.
  A number of differential scanning calorimetry studies have investigated the compatibility of stearic acid with drugs. Although such laboratory studies have suggested incompatibilities, e.g. with naproxen, they may not necessarily be applicable to formulated products.
  Stearic acid has been reported to cause pitting in the film coating of tablets applied using an aqueous film-coating technique; the pitting was found to be a function of the melting point of the stearic acid.

• 規制状況(Regulatory Status)

  GRAS listed. Accepted as a food additive in Europe (fatty acids). Included in the FDA Inactive Ingredients Database (sublingual tablets; oral capsules, solutions, suspensions, and tablets; topical and vaginal preparations). Included in nonparenteral medicines licensed in the UK. Included in the Canadian List of Acceptable Non-medicinal Ingredients.

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ステアリン酸 スペクトルデータ(¹HNMR、¹³CNMR、IR1、IR2、IR3、MS、Raman)

57-11-4, ステアリン酸 キーワード