ミリスチン酸 イソプロピル

危険有害性情報のコード(GHS)

• 絵表示(GHS)

  

• 注意喚起語

  Warning

• 危険有害性情報

  H315：皮膚刺激

• 注意書き

  P264：取扱い後は皮膚をよく洗うこと。

  P264：取扱い後は手や顔をよく洗うこと。

  P321：特別な処置が必要である（このラベルの．．． を見よ）。

  P332+P313：皮膚刺激が生じた場合：医師の診断/手当てを受けるこ と。

ミリスチン酸 イソプロピル 価格

MSDS Information

• Isopropyl myristate

ミリスチン酸 イソプロピル 化学特性,用途語,生産方法

• 外観

  無色〜わずかにうすい黄色, 澄明の液体

• 定義

  本品は、ミリスチン酸(*)とイソプロパノール(*)のエステルであり、次の化学式で表される。
  参照表示名称：ミリスチン酸, イソプロパノール

• 溶解性

  エタノール及びアセトンに溶け、水にほとんど溶けない。

• 解説

  1-methylethyl tetradecanoate．C17H34O2(270.44)．CH3(CH2)12COOCH(CH3)2．ミリスチン酸 イソプロピルは，ミリスチン酸と2-プロパノールとを反応させ，エステル化すると得られる．無色の透明液体．融点8～9 ℃，沸点140 ℃(0.3 kPa)．d²⁰₂₀ 0.855．n²⁰_D 1.435．208 ℃ で分解する．アセトン，エタノール，トルエン，植物油および鉱物油に可溶．化粧品用油性原料，外用医薬品基剤用原料，プラスチックや繊維の滑剤，塗料および印刷インキの添加剤，金属加工用潤滑油などに用いられる．森北出版「化学辞典（第2版）

• 用途

  化粧品原料。

• 原料由来

  石油系および混合系エステル

• 化粧品の成分用途

  エモリエント剤、結合剤、香料

• 効能

  軟化剤

• 特徴

  非常に軽くさっぱりとした使用感の低粘性の油剤。

• 説明

  Isopropyl myristate is odorless when pure. May be synthesized by conventional esterification of isopropanol with myristic acid.

• 化学的特性

  Isopropyl myristate is a clear, colorless, practically odorless liquid of low viscosity that congeals at about 5°C. It consists of esters of propan-2-ol and saturated high molecular weight fatty acids, principally myristic acid.

• 天然物の起源

  Reported found in kumquat peel oil, papaya, starfruit, plum brandy, coriander seed and loquat

• 使用

  In cosmetic and topical medicinal Preparations where good absorption through the skin is desired. A jellied isopropyl myristate was marketed as Estergel (Merck & Co.) .

• 製造方法

  By conventional esterification of isopropanol with myristic acid

• 調製方法

  Isopropyl myristate may be prepared either by the esterification of myristic acid with propan-2-ol or by the reaction of myristoyl chloride and propan-2-ol with the aid of a suitable dehydrochlorinating agent. A high-purity material is also commercially available, produced by enzymatic esterification at low temperature.

• 一般的な説明

  Isopropyl myristate is an ester of isopropyl alcohol myristic acid. It is mainly used as a solubilizer, emulsifier and emollient in cosmetic and topical medicines. It also finds applications as a flavoring agent in the food industry.
  Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

• 応用例（製薬）

  Isopropyl myristate is a nongreasy emollient that is absorbed readily by the skin. It is used as a component of semisolid bases and as a solvent for many substances applied topically. Applications in topical pharmaceutical and cosmetic formulations include bath oils; make-up; hair and nail care products; creams; lotions; lip products; shaving products; skin lubricants; deodorants; otic suspensions; and vaginal creams. For example, isopropyl myristate is a self-emulsifying component of a proposed cold cream formula, which is suitable for use as a vehicle for drugs or dermatological actives; it is also used cosmetically in stable mixtures of water and glycerol.
  Isopropyl myristate is used as a penetration enhancer for transdermal formulations, and has been used in conjunction with therapeutic ultrasound and iontophoresis.It has been used in a water-oil gel prolonged-release emulsion and in various microemulsions. Such microemulsions may increase bioavailability in topical and transdermal applications. Isopropyl myristate has also been used in microspheres, and significantly increased the release of drug from etoposide-loaded microspheres.
  Isopropyl myristate is used in soft adhesives for pressuresensitive adhesive tapes.

• 接触アレルゲン

  Despite wide use in cosmetics, perfumes, and topical medicaments, isopropyl myristate is a very weak sen- sitizer and a mild irritant.

• 副作用

  Thrapecylate myristate is a medicine used to treat head lice infestations in adults and children 4 years of age and older. Common side effects include skin irritation, rash, and contact dermatitis.

• 安全性

  Isopropyl myristate is widely used in cosmetics and topical pharmaceutical formulations, and is generally regarded as a nontoxic and nonirritant material.
  LD50 (mouse, oral): 49.7 g/kg
  LD50 (rabbit, skin): 5 g/kg

• 合成

  Isopropyl myristate is synthesized by conventional esterification of iso-Propanol with Myristic acid.

• 代謝

  Higher molecular weight aliphatic esters are thought to be readily hydrolysed to the corresponding alcohols and acids which are then metabolized; isopropyl myristate is undoubtedly hydrolysed to normal metabolic products (Fassett, 1963). When myristic acid (as the ethyl ester) was fed to dogs,

• 貯蔵

  Isopropyl myristate is resistant to oxidation and hydrolysis, and does not become rancid. It should be stored in a well-closed container in a cool, dry place and protected from light.

• 不和合性

  When isopropyl myristate comes into contact with rubber, there is a drop in viscosity with concomitant swelling and partial dissolution of the rubber; contact with plastics, e.g. nylon and polyethylene, results in swelling. Isopropyl myristate is incompatible with hard paraffin, producing a granular mixture. It is also incompatible with strong oxidizing agents.

• 規制状況(Regulatory Status)

  Included in the FDA Inactive Ingredients Database (otic, topical, transdermal, and vaginal preparations). Used in nonparenteral medicines licensed in the UK. Included in the Canadian List of Acceptable Non-medicinal Ingredients.

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