αステアロイルω（ステアロイルオキシ）ポリ（オキシエチレン）

危険有害性情報のコード(GHS)

• 注意喚起語

  Warning

αステアロイルω（ステアロイルオキシ）ポリ（オキシエチレン） 価格

αステアロイルω（ステアロイルオキシ）ポリ（オキシエチレン） 化学特性,用途語,生産方法

• 定義

  本品は、ステアリン酸(*)とPEG-150(*)のジエステルであり、次の化学式で表される。
  n：平均150
  参照表示名称：ステアリン酸, ＰＥＧ－１５０

• 化粧品の成分用途

  可溶化剤、親水性増粘剤、乳化剤、洗浄剤

• 化学的特性

  A soft, off-white solid. PH of 10% dispersion 7.26, saponification number variable. Soluble in chlorinated solvents, light esters, and acetone; slightly soluble in alcohols, insoluble in glycols, hydrocarbons, and vegetable oils. Combustible.

• 使用

  POLY(ETHYLENE GLYCOL) (N) DISTEARATE is used as an emulsifier for personal care and water treatment and as a processing aid in textile industry.

• 定義

  Distearate ester of polyglycol.

• 調製方法

  Polyethylene glycol distearate is prepared by the direct reaction of fatty acids, particularly stearic acid, with ethylene oxide.

• 応用例（製薬）

  Polyethylene glycol distearate is generally used as emulsifiers in oil-inwater- type creams and lotions. Its hydrophilicity or lipophilicity depends on the number of ethylene oxide units present: the larger the number, the greater the hydrophilic properties. Polyoxyl 40 stearate has been used as an emulsifying agent in intravenous infusions.
  Polyoxyethylene stearates are particularly useful as emulsifying agents when astringent salts or other strong electrolytes are present. It can also be blended with other surfactants to obtain any hydrophilic–lipophilic balance for lotions or ointment formulations.

• 安全性プロファイル

  Poison by intravenous route. When heated to decomposition it emits acrid smoke and irritating fumes. See also POLYETHYLENE GLYCOL.

• 安全性

  Although Polyethylene glycol distearate is primarily used as emulsifying agents in topical pharmaceutical formulations, certain materials, particularly polyoxyl 40 stearate, have also been used in intravenous injections and oral preparations.
  Polyethylene glycol distearate has been tested extensively for toxicity in animals(8–13) and are widely used in pharmaceutical formulations and cosmetics. It is generally regarded as essentially nontoxic and nonirritant materials.
  Polyoxyl 8 stearate
  (hamster, oral): 27 g/kg
  (rat, oral): 64 g/kg
  Polyoxyl 20 stearate
  (mouse, IP): 0.2 g/kg
  (mouse, IV): 0.87 g/kg

• 貯蔵

  Polyoxyethylene stearates are generally stable in the presence of electrolytes and weak acids or bases. Strong acids and bases can cause gradual hydrolysis and saponification.
  The bulk material should be stored in a well-closed container, in a dry place, at room temperature.

• 不和合性

  Polyethylene glycol distearate is unstable in hot alkaline solutions owing to hydrolysis, and will also saponify with strong acids or bases. Discoloration or precipitation can occur with salicylates, phenolic substances, iodine salts, and salts of bismuth, silver, and tannins.Complex formation with preservatives may also occur.The antimicrobial activity of some materials such as bacitracin, chloramphenicol, phenoxymethylpenicillin, sodium penicillin, and tetracycline may be reduced in the presence of polyoxyethylene stearate concentrations greater than 5% w/w.

• 規制状況(Regulatory Status)

  Included in the FDA Inactive Ingredients Database (dental solutions; IV injections; ophthalmic preparations; oral capsules and tablets; otic suspensions; topical creams, emulsions, lotions, ointments, and solutions; and vaginal preparations). Included in nonparenteral medicines licensed in the UK. Included in the Canadian List of Acceptable Non-medicinal Ingredients.

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αステアロイルω（ステアロイルオキシ）ポリ（オキシエチレン） スペクトルデータ(FT-IR、IR、Raman)

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