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アセスルファムK

アセスルファムK 化学構造式
55589-62-3
  • CAS番号.55589-62-3
  • 化学名:アセスルファムK
  • 别名:アセスルファムK;アセスルファーム-K;アセスルファムカリウム;3,4-ジヒドロ-6-メチル-4-オキソ-3-ポタシオ-1,2,3-オキサチアジン2,2-ジオキシド;3,4-ジヒドロ-6-メチル-3-ポタシオ-4-オキソ-1,2,3-オキサチアジン2,2-ジオキシド;アセスルファムK標準品;6-メチル-1,2,3-オキサチアジン-4(3H)-オン2,2-ジオキシドカリウム;6-メチル-1,2,3-オキサチアジン-4(3H)-オン2,2-ジオキシドカリウム塩;アセスルファム-K
  • 英語化学名:Acesulfame potassium
  • 英語别名:Ansai;AcesuL;sunett;SUNETTE;Ak Candy;SWEET ONE;Ccris 1032;acesulfame;Acesulfaml-K;ACESULFAME K
  • CBNumber:CB3224119
  • Molecular Formula:C4H4KNO4S
  • Formula Weight:201.24
  • MOL File:55589-62-3.mol
アセスルファムK 物理性質
  • 融点  :229-232°C (dec.)
  • 比重(密度)  :(solid) 1.81 g/cm3; d (bulk) 1.1-1.3 kg/dm3
  • 貯蔵温度  :Inert atmosphere,Room Temperature
  • 溶解性 :Soluble in water, very slightly soluble in acetone and in ethanol (96 per cent).
  • 外見  :neat
  • 色 :White crystalline solid
  • 臭い (Odor) :odorless with sweet taste
  • 水溶解度  :almost transparency
  • Merck  :14,37
  • BRN  :3637857
  • CAS データベース :55589-62-3(CAS DataBase Reference)
  • EPAの化学物質情報 :Acesulfame-potassium (55589-62-3)
安全性情報
  • Rフレーズ  :36/37/38
  • Sフレーズ  :26-36/37/39
  • WGK Germany  :1
  • RTECS 番号 :RP4489165
  • HSコード  :2934990002
  • 毒性 :LD50 in rats (mg/kg): 7431 orally, 2243 i.p. (Mayer, Kemper)
アセスルファムK 価格 もっと(29)
  • メーカー: 富士フイルム和光純薬株式会社(wako)
  • 製品番号: W01CHDASB-00001033
  • 製品説明 : アセスルファム-K
  • 純度: Acesulfame-K
  • 包装: 250mg
  • 価格: ¥17800
  • 更新時間: 2021/03/23
  • 購入: 購入
  • メーカー: 富士フイルム和光純薬株式会社(wako)
  • 製品番号: W01CHDASB-00001033
  • 製品説明 : アセスルファム-K
  • 純度: Acesulfame-K
  • 包装: 100mg
  • 価格: ¥12500
  • 更新時間: 2020/09/21
  • 購入: 購入
  • メーカー: 東京化成工業
  • 製品番号: A1490
  • 製品説明 : アセスルファムK
  • 純度: Acesulfame K >98.0%(T)
  • 包装: 25g
  • 価格: ¥3300
  • 更新時間: 2021/03/23
  • 購入: 購入
  • メーカー: 東京化成工業
  • 製品番号: A1490
  • 製品説明 : アセスルファムK
  • 純度: Acesulfame K >98.0%(T)
  • 包装: 100g
  • 価格: ¥9800
  • 更新時間: 2021/03/23
  • 購入: 購入
  • メーカー: 関東化学株式会社(KANTO)
  • 製品番号: 01690-96
  • 製品説明 : アセスルファムK標準品
  • 純度: Acesulfame K standard>99.0%(HLC)
  • 包装: 500mg
  • 価格: ¥5500
  • 更新時間: 2021/03/23
  • 購入: 購入

Acesulfame potassium 化学特性,用途語,生産方法

  • 外観 白色〜わずかにうすい黄色, 結晶〜結晶性粉末
  • 定義 本品は、含硫複素環式化合物のカリウム塩であり、次の化学式で表される。
  • 溶解性 水に溶ける。
  • 解説 人工甘味料の一。砂糖の200倍の甘さをもつがカロリーはゼロ。アセスルファムK。化学式C4H4KNO4S
    小学館 デジタル大辞泉について 情報 | 凡例
  • 用途 アセスルファムK定量用。
  • 用途 甘味料研究用。
  • 化粧品の成分用途 香味剤
  • 効能 甘味料
  • 化学的特性 White to Off-White Solid
  • 化学的特性 Acesulfame potassium occurs as a colorless to white-colored, odorless, crystalline powder with an intensely sweet taste.
  • Originator Acesulfame Potassium ,Hoechst
  • 来歴 Acesulfame-K, the potassium salt of acesulfame, is a sweetener that resembles saccharin in structure and taste profile. 5,6-Dimethyl-1,2,3-oxathiazine-4(3H)-one 2,2-dioxide, the first of many sweet compounds belonging to the dihydrooxathiazinone dioxide class, was discovered accidentally in 1967. From these many sweet compounds, acesulfame was chosen for commercialization. To improve water solubility, the potassium salt was made. Acesulfame-K (Sunett) was approved for dry product use in the United States in 1988 and in Canada in October, 1994. In 2003, acesulfame-K was approved as a general purposes sweetener by the FDA.
  • 使用 Potassium salt as sweetener for foods, cosmetics.
  • 使用 Acesulfame-K is the potassium salt of 6-methyl-l,2,3-oxathiazin-4(3H)- one-2,2-dioxide. This sweetener was discovered in Germany and was first approved by the FDA in 1988 for use as a nonnutritive sweetener. The complex chemical name of this substance led to the creation of the trademark common name, acesulfame-K, which is based on its following relationships to acetocetic acid and sulfanic acid, and to its potassium salt nature.
    Acesulfame-K is 200 times as sweet as sugar and is not metabolized and is thus noncaloric. It is exceptionally stable at elevated temperatures encountered in baking, and it is also stable in acidic products, such as carbonated soft drinks. It has a synergistic effect when mixed with other low-calorie sweetners, such as aspartame. Common applications of acesulfame-K are table uses, chewing gums, beverages, foods, bakery products, confectionary, oral hygiene products, and pharmaceuticals.
  • 使用 'New generation', heat-stable sweetener that has not been suspected to cause cancer nor be genotoxic. Allelic variation of the Tas1r3 gene affects behavioral taste responses to this molecule, suggesting that it is a T1R3 receptor ligand.
  • 調製方法 Acesulfame potassium is synthesized from acetoacetic acid tertbutyl ester and fluorosulfonyl isocyanate. The resulting compound is transformed to fluorosulfonyl acetoacetic acid amide, which is then cyclized in the presence of potassium hydroxide to form the oxathiazinone dioxide ring system. Because of the strong acidity of this compound, the potassium salt is produced directly.
    An alternative synthesis route for acesulfame potassium starts with the reaction between diketene and amidosulfonic acid. In the presence of dehydrating agents, and after neutralization with potassium hydroxide, acesulfame potassium is formed.
  • 調製方法 The principal commercial process for acesulfame-K is depicted below: 

  • Manufacturing Process 80 g (1.096 mol) of dimethylethylamine were added drop-wise, with cooling, to 80 g (0.825 mol) of sulfamic acid suspended in 500 ml of glacial acetic acid. When dissolution was complete, 80 ml (1.038 mol) of diketene were added, while cooling at 25°-35°C. After 16 hours, the mixture was evaporated and the residue was stirred with acetone, whereupon crystallization of dimethylethylammonium acetoacetamide-N-sulfonate took place. Yield: 110 g (43%), melting point 73°-75°C.
    12.7 g (50 mmol) of dimethylethylammonium acetoacetamide-N-sulfonate in 110 ml of methylene chloride were added drop-wise to 8 ml (200 mmol) of liquid SO3 in 100 ml of CH2Cl2 at -30°C, stirring vigorously, within 60 minutes. 30 minutes later, 50 ml of ethyl acetate and 50 g of ice were added to the solution. The organic phase was separated off, and the aqueous phase was extracted twice more with ethyl acetate. The combined organic phases were dried over sodium sulfate, evaporated and the residue was dissolved in methanol. On neutralization of the solution with methanolic KOH, the potassium salt of 6-methyl-3,4-dihydro-1,2,3-oxathiazin-4-one 2,2-dioxide precipitated out. Yield: 7.3 g (73%). The product was detected by thinlayer chromatography; the structure of it was confirmed with IR spectrum.
  • Therapeutic Function Pharmaceutic aid
  • 応用例(製薬) Acesulfame potassium is used as an intense sweetening agent in cosmetics, foods, beverage products, table-top sweeteners, vitamin and pharmaceutical preparations, including powder mixes, tablets, and liquid products. It is widely used as a sugar substitute in compounded formulations,and as a toothpaste sweetener.
    The approximate sweetening power is 180–200 times that of sucrose, similar to aspartame, about one-third as sweet as sucralose, one-half as sweet as sodium saccharin, and about 4-5 times sweeter than sodium cyclamate.It enhances flavor systems and can be used to mask some unpleasant taste characteristics.
  • 安全性プロファイル When heated to decompositionemits toxic fumes of SOx.
  • 安全性 Acesulfame potassium is widely used in beverages, cosmetics, foods, and pharmaceutical formulations, and is generally regarded as a relatively nontoxic and nonirritant material. Pharmacokinetic studies have shown that acesulfame potassium is not metabolized and is rapidly excreted unchanged in the urine. Long-term feeding studies in rats and dogs showed no evidence to suggest acesulfame potassium is mutagenic or carcinogenic.
    The WHO has set an acceptable daily intake for acesulfame potassium of up to 15 mg/kg body-weight.The Scientific Committee for Foods of the European Union has set a daily intake value of up to 9 mg/kg of body-weight.
    LD50 (rat, IP): 2.2 g/kg
    LD50 (rat, oral): 6.9–8.0 g/kg
  • 貯蔵 Acesulfame potassium possesses good stability. In the bulk form it shows no sign of decomposition at ambient temperature over many years. In aqueous solutions (pH 3.0–3.5 at 208℃) no reduction in sweetness was observed over a period of approximately 2 years. Stability at elevated temperatures is good, although some decomposition was noted following storage at 408℃ for several months. Sterilization and pasteurization do not affect the taste of acesulfame potassium.
    The bulk material should be stored in a well-closed container in a cool, dry place and protected from light.
  • 規制状況(Regulatory Status) Included in the FDA Inactive Ingredients Database for oral and sublingual preparations. Included in the Canadian List of Acceptable Non-medicinal Ingredients. Accepted for use in Europe as a food additive. It is also accepted for use in certain food products in the USA and several countries in Central and South America, the Middle East, Africa, Asia, and Australia.
アセスルファムK 上流と下流の製品情報
原材料
準備製品
アセスルファムK 生産企業
Global(362)Suppliers
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55589-62-3, アセスルファムK キーワード:
  • 55589-62-3
  • 6-METHYL-1,2,3-OXATHIAZIN-4(3H)-ONE 2,2-DIOXIDE POTASSIUM SALT
  • ACESULFAME K
  • ACESULFAME POTASSIUM SALT
  • ACESULFAME POTASSIUM(AK)
  • ACESULPHAME-K
  • POTASSIUMACESULFAMEK
  • ASPARTAMEACESULPHAMESALT
  • ACESULPHAMEPOTASSIUM
  • 6-Methyl-3,4-dihydro-1,2,3-oxathiazin-4-on-2,2-dioxid, Kaliumsalz
  • Blended sweetener of acesulfame-kwith aspartame
  • Acesulfaml-K
  • 3,4-Dihydro-6-methyl-3-potassio-4-oxo-1,2,3-oxathiazine 2,2-dioxide
  • 3,4-Dihydro-6-methyl-4-oxo-3-potassio-1,2,3-oxathiazine 2,2-dioxide
  • Ccris 1032
  • Einecs 259-715-3
  • Acesulfame K,6-Methyl-1,2,3-oxathiazin-4(3H)-one 2,2-dioxide potassium salt
  • 6-Methyl-1,2,3-oxathiazin-4(3H)-one 2,2-Dioxide Potassium Salt Potassium 6-Methyl-1,2,3-oxathiazin-4(3H)-one 2,2-Dioxide
  • Acesulfame Potassium (200 mg)
  • potassium 6-methyl-2,2-dioxo-4-oxathiazinolate
  • AcesuL
  • fame potassium [NF]
  • acesulfame
  • ACESULFAME POTASSIUM
  • Acesulfame potassium Joyce
  • Ak Candy
  • Acessulfame-K
  • 1,2,3-oxathiazin-4(3h)-one,6-methyl-,2,2-dioxide,potassiumsalt
  • 6-methyl-3,4-dihydro-1,2,3-oxathiazin-4-one2,2-dioxidepotassiumsalt
  • Acesulfamum Kalicum
  • potassiumacesulfame
  • アセスルファムK
  • アセスルファーム-K
  • アセスルファムカリウム
  • 3,4-ジヒドロ-6-メチル-4-オキソ-3-ポタシオ-1,2,3-オキサチアジン2,2-ジオキシド
  • 3,4-ジヒドロ-6-メチル-3-ポタシオ-4-オキソ-1,2,3-オキサチアジン2,2-ジオキシド
  • アセスルファムK標準品
  • 6-メチル-1,2,3-オキサチアジン-4(3H)-オン2,2-ジオキシドカリウム
  • 6-メチル-1,2,3-オキサチアジン-4(3H)-オン2,2-ジオキシドカリウム塩
  • アセスルファム-K
  • カリウム化合物
  • 典型金属化合物
  • 構造分類
  • 金属別化合物