N-アセチル-D-グルコサミン

危険有害性情報のコード(GHS)

• 絵表示(GHS)

  

• 注意喚起語

  Danger

• 危険有害性情報

  H314：重篤な皮膚の薬傷?眼の損傷

• 注意書き

  P280：保護手袋/保護衣/保護眼鏡/保護面を着用するこ と。

  P305+P351+P338：眼に入った場合：水で数分間注意深く洗うこと。次にコ ンタクトレンズを着用していて容易に外せる場合は外す こと。その後も洗浄を続けること。

  P310：ただちに医師に連絡すること。

N-アセチル-D-グルコサミン 価格

N-アセチル-D-グルコサミン 化学特性,用途語,生産方法

• 外観

  白色～ほとんど白色, 結晶性粉末～粉末

• 定義

  本品は、次の化学式で表されるN-アセチル化アミノ糖である。

• 溶解性

  水及びメタノールに溶ける。

• 解説

  N-アセチル-D-グルコサミン,D-体のα-ピラノース形は融点205 ℃．[α]_D"＋64→＋41°(水)．β-ピラノース形は融点182～183.5 ℃．[α]_D"－22→＋41°(水)．エルソン-モルガン法を利用して検出，定量される．医薬品の原料に用いられる．
  森北出版「化学辞典（第2版）
  

• 用途

  医薬及び化粧品の原料、アミノ糖研究用。

• 化粧品の成分用途

  皮膚コンディショニング剤

• 製造

  N-アセチル-D-グルコサミン,略号GlcNAc．グルコサミンのアミノ基をアセチル化したもの．D-体はキチン質をはじめ，ムコ多糖，糖タンパク質，糖脂質の構成成分であり，広く生物界に分布している．水またはメタノール中グルコサミンに小過剰の無水酢酸を作用させると得られる．

• 説明

  N-Acetyl-D-Glucosamine is the N-acetyl derivative of glucosamine.Chemically it is an amide between glucosamine and acetic acid. A single N-acetlyglucosamine moiety linked to serine or threonine residues on nuclear and cytoplasmic proteins -O-GlcNAc, is an ubiquitous post-translational protein modification. O-GlcNAc modified proteins are involved in sensing the nutrient status of the surrounding cellular environment and adjusting the activity of cellular proteins accordingly. O-GlcNAc regulates cellular responses to hormones such as insulin, initiates a protective response to stress, modulates a cell's capacity to grow and divide, and regulates gene transcription. In humans, it exists in skin, cartilage and blood vessel as a component of hyaluronic acid, and bone tissue, cornea and aorta as a component of keratan sulfate.
  N-Acetyl-D-glucosamine (D-GlcNAc) is a derivitized glucose monomer found in polymers of bacterial cell walls, chitin, hyaluronic acids and various glycans. It is also synthesized in the glycosylation pathway as uridine diphosphate (UDP-GlcNAc), which can then be released following degradation of glycosylated proteins.D-GlcNAc is used to identify, differentiate and characterize N-acetyl-β-D-hexoaminidase(s). It is also used in the treatment of osteoarthritis and inflammatory bowel disease (IBD), including ulcerative colitis and Crohn's disease. Further, it is used as a substrate in sialic acid production, cosmetics and in drug development research.

• 化学的特性

  White powder

• 使用

  N-acetyl-D-Glucosamine (GlcNAc) is a monosaccharide derivative of glucose. It is released by the action of O-GlcNAcase, in mammalian systems from proteins that have been post-translationally modified with O-GlcNAc.D-GlcNAc enhances the proliferation and collagen expression of fibroblasts, reduces hyperpigmentation and is therefore considered a valuable ingredient in cosmetics for improving skin wrinkles and color.Important substrate for the production of sialic acids.Used in multiple other applications in drug development and food supplement, based on a newly described bio-wave model.

• 使用

  N-Acetyl-D-glucosamine is used in the identification and characterization of N-acetyl-beta-D-hexoaminidase. It is also used in the treatment of osteoarthritis and inflammatory bowel disease (IBD), including ulcerative colitis and Crohn's disease. Further, it is used as a substrate in sialic acid production, cosmetics and in drug development research.

• 定義

  ChEBI: N-acetyl-D-glucosamine is the D isomer of N-acetylglucosamine. It has a role as a bacterial metabolite. It is a N-acetylglucosamine and a N-acetyl-D-hexosamine.

• 一般的な説明

  N-Acetyl-D-glucosamine (GlcNAc) is a monosaccharide, derived from glucose and undergoes linear polymerization by (1,4)-β-linkages to form the polymer chitin. It is also a component of heterogenous polysaccharides, such as murein and hyaluronic acid. N-acetylglucosamine exhibits anti-inflammatory properties and is considered as a potential drug in the treatment of osteoarthritis. Its antiarthritic mode of mechanism involves the suppression of IL-1β (Interleuken-1β)-induced NO (nitric oxide), cyclooxygenase-2 (COX-2), and IL-6 production by inhibition of expression of iNOS (inducible nitric oxide synthase) protein and mRNA.
  Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

• Biochem/physiol Actions

  N-Acetyl-D-glucosamine (GlcNAc) oligomer may have the ability to initiate factors for canine polymorphonuclear cells (PMN) in vivo. It possesses wound healing and chemotactic activity. GlcNAc and its derivatives are usually employed in preparing dietary supplements and also used in therapeutic development.

• 概要

  動植物，微生物の糖タンパク，糖脂質，ムコ多糖の成分，キチンの最小単位．細菌細胞壁の成分．シアル酸合成の前駆体

N-アセチル-D-グルコサミン 上流と下流の製品情報

N-アセチル-D-グルコサミン 生産企業

Global(833)Suppliers

N-アセチル-D-グルコサミン スペクトルデータ(¹HNMR、¹³CNMR、IR1、IR2、MS、Raman)

7512-17-6, N-アセチル-D-グルコサミン キーワード