gamma-Butyrolacton

Bezeichnung:gamma-Butyrolacton

CAS-Nr96-48-0

Englisch Name:Gamma Butyrolactone

CBNumberCB9719491

SummenformelC4H6O2

Molgewicht86.09

MOL-Datei96-48-0.mol

Synonyma

γ-Butyrolacton

gamma-Butyrolacton

1,4-Butanolid

gamma-Butyrolacton physikalisch-chemischer Eigenschaften

Schmelzpunkt	-45 °C (lit.)
Siedepunkt	204-205 °C (lit.)
Dichte	1.12 g/mL at 25 °C (lit.)
Dampfdichte	3 (vs air)
Dampfdruck	1.5 mm Hg ( 20 °C)
Brechungsindex	n20/D 1.436(lit.)
FEMA	3291 \| 4-HYDROXYBUTANOIC ACID LACTONE
Flammpunkt	209 °F
storage temp.	2-8°C
Löslichkeit	DMF: 10 mg/ml; DMSO: 10 mg/ml; Ethanol: 10 mg/ml; PBS (pH 7.2): 1 mg/ml
Farbe	Clear colorless
Säure-Base-Indikators(pH-Indikatoren)	4 at 100 g/l at 20 °C
Geruch (Odor)	at 100.00 %. creamy oily fatty caramel
Geruchsart	creamy
Explosionsgrenze	16%
Wasserlöslichkeit	MISCIBLE
Merck	13,1596
JECFA Number	219
BRN	105248
Dielectric constant	40.960000000000001
Stabilität	Stable. Hygroscopic. Incompatible with strong oxidizing agents, strong acids, strong bases, strong reducing agents.
InChIKey	YEJRWHAVMIAJKC-UHFFFAOYSA-N
LogP	-0.566 at 25℃
CAS Datenbank	96-48-0(CAS DataBase Reference)
IARC	3 (Vol. 11, Sup 7, 71) 1999
NIST chemische Informationen	«gamma»-Butyrolactone(96-48-0)
EPA chemische Informationen	.gamma.-Butyrolactone (96-48-0)

Sicherheit

Kennzeichnung gefährlicher	Xn,F
R-Sätze:	22-36-67-41-20/21/22-11
S-Sätze:	26-36-39-36/37-16
WGK Germany	1
RTECS-Nr.	LU3500000
Selbstentzündungstemperatur	851 °F
TSCA	Yes
HS Code	29322980
Giftige Stoffe Daten	96-48-0(Hazardous Substances Data)
Toxizität	LD50 orally in rats: 17.2 ml/kg (Smyth)

Gefahreninformationscode (GHS)

Gamma Butyrolactone Chemische Eigenschaften,Einsatz,Produktion Methoden

ERSCHEINUNGSBILD
FARBLOSE, öLIGE, HYGROSKOPISCHE FLüSSIGKEIT.
CHEMISCHE GEFAHREN
Reagiert mit Säuren, Basen, Alkoholenund Aminen. Zersetzung beim Verbrennen unter Bildung reizender Rauche.
ARBEITSPLATZGRENZWERTE
TLV nicht festgelegt (ACGIH 2005).
MAK nicht festgelegt (DFG 2005).
AUFNAHMEWEGE
Aufnahme in den Körper durch Inhalation der Dämpfe und durch Verschlucken.
INHALATIONSGEFAHREN
Nur ungenügende Angaben vorhanden über die Geschwindigkeit, mit der eine gesundheitsschädliche Konzentration in der Luft beim Verdampfen bei 20°C erreicht wird.
WIRKUNGEN BEI KURZZEITEXPOSITION
WIRKUNGEN BEI KURZZEITEXPOSITION:
Die Substanz reizt die Augen. Beim Verschlucken sind Auswirkungen auf das Zentralnervensystem mit nachfolgendem Atemversagenmöglich. Exposition kann Bewusstseinstrübung verursachen.
LECKAGE
Ausgelaufene Flüssigkeit in abdichtbaren Behältern sammeln. Reste mit Sand oder inertem Absorptionsmittel aufnehmen und an einen sicheren Ort bringen. Persönliche Schutzausrüstung: Atemschutzfilter für organische Gase und Dämpfe.
R-Sätze Betriebsanweisung:
R22:Gesundheitsschädlich beim Verschlucken.
R36:Reizt die Augen.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
S39:Schutzbrille/Gesichtsschutz tragen.
Beschreibung
Dihydro-2(3H)-furanone. An endogenous neuroregulator made from gamma-amino butyrate and the precursor of gamma hydroxybutyrate. It causes selective increase of brain dopamine by inhibiting its release from nerve terminals. The compound has sedative properties at low doses and produces surgical anesthesia at high doses. It is also used as an industrial solvent and precursor.
Chemische Eigenschaften
γ-Butyrolactone is oily, colorless, clear liquid. It has a faint, sweet, aromatic, slightly buttery odor.

γ-Butyrolactone is a lactone. It is hydrolyzed under basic conditions, for example in a sodium hydroxide solution into sodium gamma-hydroxybutyrate, the sodium salt of gamma-hydroxybutyric acid. Under acidic conditions it forms an equilibrium mixture of both compounds. These compounds then may go on to form a polymer.
Occurrence
Reported found as a constituent in coffee aroma; a volatile flavor component in roasted filberts as well. Also reported found in tomato, potato, soybeans, beans, vinegar, mushrooms, roasted chicken, beef, cider, beer, wine, scallops and clams.
Verwenden
r-butyrolactone is one kind of important fine chemicalintermediate, simultaneously also is one kind of performance fine highboiling point solvent, ideal antioxidant, plasticizer,extracting agent, absorbent, dispersing agent, solid stain, Coagulation Reagent.
Verwenden
For the introduction of 3-carboxypropyl side chain. Used as a component of electrolyte solutions in batteries and capacitors.
Verwenden
Intermediate in the synthesis of polyvinylpyrrolidone, DL-methionine, piperidine, phenylbutyric acid, thiobutyric acids. Solvent for polyacrylonitrile, cellulose acetate, methyl methacrylate polymers, polystyrene. Constituent of paint removers, textile aids, drilling oils.
Definition
ChEBI: A butan-4-olide that is tetrahydrofuran substituted by an oxo group at position 2.
synthetische
γ-Butyrolactone is produced by gas phase 1,4-butanediol under the action of Cu catalyst to produce product γ-butyrolactone and by-product hydrogen. Crude γ-Butyrolactone is purified to remove light and heavy components, with a purity of more than 99.5%, as an export product. At the same time, the by-product hydrogen is sent to other hydrogenation processes for recycling after removing CO and CO2 through the methanation process.
Aroma threshold values
Detection: 20 to 50 ppm
Taste threshold values
Taste characteristic at 75 ppm: milky, creamy with fruity peach-like afternotes.
Allgemeine Beschreibung
Clear colorless oily liquid with a pleasant odor.
Air & Water Reaktionen
Hygroscopic. Soluble in water.
Reaktivität anzeigen
gamma-Butyrolactone can react with oxidizing materials, inorganic acids and bases, alcohols and amines. Rapidly hydrolyzed by bases and slowly hydrolyzed by acids. gamma-Butyrolactone is volatile with steam. . The combination of the lactone, butanol, 2,4-dichlorophenol, and sodium hydroxide in the attempted synthesis of 2,4-dichlorophenoxybutyric acid caused a thermal runaway reaction that eventually exploded, [CISHC Chem. Safety Summ., 1977, 48, 3].
Hazard
Toxic by ingestion. Questionable carcino- gen.
Brandgefahr
gamma-Butyrolactone is combustible.
Biochem/physiol Actions
Precursor of γ-hydroxybutyric acid (GHB). It blocks dopamine release by blocking impulse flow in dopaminergic neurons. Pretreatment with γ-butyrolactone allows detection of autoreceptor-induced dopamine release.
Sicherheitsprofil
Moderately toxic by ingestion, intravenous, and intraperitoneal routes. An experimental teratogen. Other experimental reproductive effects. Questionable carcinogen with experimental tumorigenic data by skin contact. Mutation data reported. Less acutely toxic than ppropiolactone. Combustible when exposed to heat or flame; can react with oxidizing materials. To fight fire, use foam, alcohol foam, CO2, dry chemical. Potentially explosive reaction with butanol + 2,4 dichlorophenol + sodium hydroxide. When heated to decomposition it emits acrid and irritating fumes.
mögliche Exposition
Used as a chemical intermediate for making other chemicals, including pesticides, cosmetics, and pharmaceuticals; as a solvent for paint, nail polish removers, and industrial chemicals. Used in electronics, drilling and petroleum industries as a stabilizer and solvent. Used as a flavoring agent in various foods and beverages, including grains and breakfast foods, candy, and alcoholic and nonalcoholic drinks. Drug of abuse: the United States Food and Drug Administration has warned the public not to purchase or consume products, containing gamma-butyrolactone (GBL). FDA has also asked the companies that manufacture these products to voluntarily recall them. The agency has received reports of serious health problems—some that are potentially life-threatening—associated with the use of these products. Although labeled as dietary supplements and marketed under various brand names, these products are illegally marketed unapproved new drugs. False advertising claims include building muscles, improved physical performance, enhanced sex, reduced stress and induced sleep
Versand/Shipping
Listed by some sources as unregulated. UN2810 Toxic liquids, organic, n.o.s., Hazard Class: 6.1; Labels: 6.1—Poisonous materials, Technical Name Required.
läuterung methode
Dry the lactone over anhydrous CaSO4, then fractionally distil it. Handle it in a fume cupboard due to its TOXICITY. [Beilstein 17 V 7.]
Inkompatibilitäten
4-Butyrolactone is incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, alcohols, amines, strong and inorganic acids, strong bases. Rapidly hydrolyzed by bases and slowly hydrolyzed by acids. It is hygroscopic and volatile with steam. Combustible; vapor may form explosive mixture with air.
Waste disposal
Use a licensed professional waste disposal service to dispose of this material. Dissolve or mix the material with a combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber. It is inappropriate and possibly dangerous to the environment to dispose of expired or waste drugs and pharmaceuticals by flushing them down the toilet or discarding them to the trash. Household quantities of expired or waste pharmaceuticals may be mixed with wet cat litter or coffee grounds, double-bagged in plastic, discard in trash. Larger quantities shall carefully take into consideration applicable DEA, EPA, and FDA regulations. If possible return the pharmaceutical to the manufacturer for proper disposal being careful to properly label and securely package the material. Alternatively, the waste pharmaceutical shall be labeled, securely packaged and transported by a state licensed medical waste contractor to dispose by burial in a licensed hazardous or toxic waste landfill or incinerator. All federal, state, and local environmental regulations must be observed.

Gamma Butyrolactone Upstream-Materialien And Downstream Produkte

96-48-0, Gamma Butyrolactone Verwandte Suche:

Send Inquriy