Cyclopropylamin

Bezeichnung:Cyclopropylamin

CAS-Nr765-30-0

Englisch Name:Cyclopropylamine

CBNumberCB1782699

SummenformelC3H7N

Molgewicht57.09

MOL-Datei765-30-0.mol

Synonyma

Cyclopropylamin

Cyclopropylamin physikalisch-chemischer Eigenschaften

Schmelzpunkt	-50 °C
Siedepunkt	49-50 °C (lit.)
Dichte	0.824 g/mL at 25 °C (lit.)
Dampfdruck	4.67 psi ( 20 °C)
Brechungsindex	n20/D 1.420(lit.)
Flammpunkt	−14 °F
storage temp.	Store below +30°C.
Löslichkeit	Chloroform, Ethyl Acetate (Sparingly), Methanol (Slightly)
Aggregatzustand	Volatile Liquid
pka	pK1:9.10(+1) (25°C)
Farbe	Clear colorless
Wichte	0.824
Wasserlöslichkeit	Miscible with water, ethanol,ether and chloroform.
Sensitive	Lachrymatory
BRN	741858
Stabilität	Volatile
InChIKey	HTJDQJBWANPRPF-UHFFFAOYSA-N
LogP	0.070
CAS Datenbank	765-30-0(CAS DataBase Reference)
NIST chemische Informationen	Cyclopropylamine(765-30-0)
EPA chemische Informationen	Cyclopropanamine (765-30-0)

Sicherheit

Kennzeichnung gefährlicher	F,C,Xi
R-Sätze:	11-22-34-36/37
S-Sätze:	16-26-36/37/39-45-33-7/9
RIDADR	UN 2733 3/PG 2
WGK Germany	2
RTECS-Nr.	GZ0685500
Selbstentzündungstemperatur	527 °F
Hazard Note	Extremely Flammable/Harmful/Corrosive/Lachrymatory
TSCA	T
HazardClass	3
PackingGroup	II
HS Code	29213099
Toxizität	LD50 orally in Rabbit: 445 mg/kg

Gefahreninformationscode (GHS)

Cyclopropylamine Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R11:Leichtentzündlich.
R22:Gesundheitsschädlich beim Verschlucken.
R34:Verursacht Verätzungen.
R36/37:Reizt die Augen und die Atmungsorgane.
S-Sätze Betriebsanweisung:
S16:Von Zündquellen fernhalten - Nicht rauchen.
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
S33:Maßnahmen gegen elektrostatische Aufladungen treffen.
S7/9:Behälter dicht geschlossen an einem gut gelüfteten Ort aufbewahren.
Chemische Eigenschaften
Cyclopropylamine is a colorless and transparent flammable liquid with volatility and ammonia odor. It is miscible with water, methanol, ethanol, benzene, toluene and other solvents.
Verwenden
Cyclopropylamine is used in the preparation of N-[4-(4-fluoro)phenyl-2-aminothiazol-5-yl]pyrimidin-2-yl-alkylamine derivatives. It is also used to prepare Pt(CPA)2(bismethylthiomethylenepropanedioate) and Pt(CPA)2(bisethylthiomethylenepropanedioate) complexes.
Definition
ChEBI: Cyclopropylamine is a primary aliphatic amine that consists of cyclopropane bearing a single amino substituent. It has a role as a mouse metabolite.
Application
Cyclopropylamine is mainly used in organic synthesis, pharmaceutical synthesis intermediates, and can be used in the synthesis of new antibacterial drugs ciprofloxacin products, such as the synthesis of ciprofloxacin, enrofloxacin, spafloxacin and other drugs. In addition, cyclopropylamine is also an important intermediate for the synthesis of pesticides, plant protection agents and herbicides, such as 2-chloro-4-6-cyclopropyl-s-triazine, cyprochlor, cyproterazine, cyprocyanine and other cyclopropanes class of pesticides.
synthetische
Cyclopropylamine is synthesized from 1,3-propanediol by bromination, cyanation, cyclization, amidation, and Hoffmann rearrangement. It is also synthesized with γ-butyrolactone and isopropanol by five steps of ring-opening esterification, cyclization, hydrolysis, acylation and Hofmann degradation.
Biochem/physiol Actions
Cyclopropylamine inactivates cytochrome P450 enzymes by a mechanism involving initial one-electron oxidation at nitrogen followed by scission of the cyclopropane ring leading to covalent modification of the enzyme. It is a mechanism-based inhibitor of quinoprotein methylamine dehydrogenase from Paracoccus denitrificans.
läuterung methode
It has been isolated as the benzamide m 100.6-101.0o (from aqueous EtOH). It forms a picrate m 149o (from EtOH/pet ether) from which the free base can be recovered using a basic ion-exchange resin and can then be distilled through a Todd column (p 11) using an automatic still head which only collects products boiling below 51o/atm. Polymeric materials if present will boil above this temperature. The hydrochloride has m 85-86o [Roberts & Chambers J Am Chem Soc 73 5030 1951, Jones J Org Chem 9 484 1944, Emmons J Am Chem Soc 79 6522 1957]. [Beilstein 12 IV 3.]

Cyclopropylamine Upstream-Materialien And Downstream Produkte

Cyclopropylamin Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

765-30-0, Cyclopropylamine Verwandte Suche:

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