2-Brom-4-butanolid

Bezeichnung:2-Brom-4-butanolid

CAS-Nr5061-21-2

Englisch Name:2-Bromo-4-butanolide

CBNumberCB0139728

SummenformelC4H5BrO2

Molgewicht164.99

MOL-Datei5061-21-2.mol

Synonyma

2-Brom-4-butanolid

2-Brom-4-butanolid physikalisch-chemischer Eigenschaften

Siedepunkt	138 °C/6 mmHg (lit.)
Dichte	1.786 g/mL at 25 °C (lit.)
Brechungsindex	n20/D 1.508(lit.)
Flammpunkt	>230 °F
storage temp.	Inert atmosphere,2-8°C
Löslichkeit	Acetone, Chloroform, Ethyl Acetate, Methanol
Aggregatzustand	Clear Colourless to Light Yellow Liquid
Wichte	1.778 (20/4℃)
Farbe	Yellow
Aussehen	Colorless to light yellow Liquid
Sensitive	Moisture Sensitive/Lachrymatory
BRN	107800
InChI	InChI=1S/C4H5BrO2/c5-3-1-2-7-4(3)6/h3H,1-2H2
InChIKey	LFJJGHGXHXXDFT-UHFFFAOYSA-N
SMILES	O1CCC(Br)C1=O
CAS Datenbank	5061-21-2(CAS DataBase Reference)
NIST chemische Informationen	2(3H)-Furanone, 3-bromodihydro-(5061-21-2)
EPA chemische Informationen	2(3H)-Furanone, 3-bromodihydro- (5061-21-2)

Sicherheit

Kennzeichnung gefährlicher	Xi
R-Sätze:	36/37/38
S-Sätze:	26-36
RIDADR	UN 2810
WGK Germany	3
F	21
Hazard Note	Irritant/Keep Cold/Lachrymatory/Moisture Sensitive
TSCA	TSCA listed
HS Code	29322980
Speicherklasse	10 - Combustible liquids

Gefahreninformationscode (GHS)

2-Bromo-4-butanolide Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Chemische Eigenschaften
Pale Yellow Liquid
Verwenden
Lactams inhibit type Q arylesterase activity of human serum paraoxonase PON1.
Synthese

96-48-0

5061-21-2

General procedure for the synthesis of α-bromo-γ-butyrolactone from γ-butyrolactone (bromination step): in a 1000 mL reaction vessel equipped with a stirring device, refluxing device, thermometer, dropping funnel, and nitrogen introduction tube, 200 g (2.32 mol) of γ-butyrolactone and 2.76 g (0.086 mol based on 3.7 mol% of γ-butyrolactone) of sulfur were added as the catalyst. 431 g (2.70 mol) of bromine was loaded into a dropping funnel. Stirring was initiated, the reaction temperature was controlled not to exceed 40 °C, and the bromine was slowly added dropwise. After the dropwise addition was completed, the reaction temperature was raised to about 90 °C and the reaction was maintained at this temperature for 1 hour. Subsequently, the temperature was raised to about 110°C and the reaction was continued for 3 hours.
Einzelnachweise
[1] Patent: JP5837752, 2015, B2. Location in patent: Paragraph 0052; 0079-0081; 0082; 0085; 0086; 0088
[2] Journal of Porphyrins and Phthalocyanines, 2010, vol. 14, # 1, p. 89 - 100
[3] Bioorganic and Medicinal Chemistry Letters, 2011, vol. 21, # 10, p. 3074 - 3077
[4] Synlett, 2005, # 17, p. 2648 - 2652
[5] Organic Letters, 2011, vol. 13, # 14, p. 3670 - 3673

2-Bromo-4-butanolide Upstream-Materialien And Downstream Produkte

2-Brom-4-butanolid Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

5061-21-2, 2-Bromo-4-butanolide Verwandte Suche:

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