Diethylstilbestrol Produkt Beschreibung

Diethylstilbestrol Struktur
56-53-1
  • CAS-Nr.56-53-1
  • Bezeichnung:Diethylstilbestrol
  • Englisch Name:Diethylstilbestrol
  • Synonyma:Diethylstilbestrol
    DES;Stil;CSM1;CSM2;-PVT;ALPHA;Bufon;Cyren;Desma;Sibol
  • CBNumber:CB9751457
  • Summenformel:C18H20O2
  • Molgewicht:268.35
  • MOL-Datei:56-53-1.mol
Diethylstilbestrol physikalisch-chemischer Eigenschaften
  • Schmelzpunkt: :170-172 °C(lit.)
  • Siedepunkt: :351.51°C (rough estimate)
  • Dichte :1.1096 (rough estimate)
  • Brechungsindex :1.4800 (estimate)
  • storage temp.  : 0-6°C
  • Löslichkeit :methanol: 0.1 g/mL, clear, faintly yellow
  • pka :pKa 9.02(H2O t=25 I=0.025) (Uncertain)
  • Aggregatzustand :Crystalline Powder
  • Farbe :White to almost white
  • Wasserlöslichkeit :PRACTICALLY INSOLUBLE
  • Merck  :13,3155
  • BRN  :2056095
  • Stabilität: :Isomerizes rapidly in Benzene, Chloroform, and Ether. Keep Shielded from light.
  • CAS Datenbank :56-53-1(CAS DataBase Reference)
  • NIST chemische Informationen :Diethylstilbesterol(56-53-1)
  • EPA chemische Informationen :Phenol, 4,4'-[(1E)-1,2-diethyl- 1,2-ethenediyl]bis-(56-53-1)
Sicherheit

Diethylstilbestrol Chemische Eigenschaften,Einsatz,Produktion Methoden

  • R-Sätze Betriebsanweisung: R45:Kann Krebs erzeugen.
    R61:Kann das Kind im Mutterleib schädigen.
    R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
    R51/53:Giftig für Wasserorganismen, kann in Gewässern längerfristig schädliche Wirkungen haben.
    R40:Verdacht auf krebserzeugende Wirkung.
  • S-Sätze Betriebsanweisung: S53:Exposition vermeiden - vor Gebrauch besondere Anweisungen einholen.
    S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
    S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
    S60:Dieses Produkt und sein Behälter sind als gefährlicher Abfall zu entsorgen.
    S61:Freisetzung in die Umwelt vermeiden. Besondere Anweisungen einholen/Sicherheitsdatenblatt zu Rate ziehen.
  • Chemische Eigenschaften White Solid
  • Verwenden A synthetic, nonsteroidal estrogen. Recomended solvents are DMSO, DMF and ethanol, even in these solvents do not store in solution for any prolonged period of time.
  • Trademarks Stilbestrol (Tablicaps); Stilbetin (Bristol-Myers Squibb);Distilbene;Oestro-gynedron;Stilphostrol.
  • Weltgesundheitsorganisation (WHO) Diethylstilbestrol, a synthetic estrogen which is a stilbene derivative, was introduced into obstetric practice in the late 1940s and subsequently widely used for the treatment of threatened abortion. This use was later shown to be associated with an increased risk of vaginal cancer in the offspring which resulted in restrictive regulatory action in several countries. Diethylstilbestrol and other stilbenes remain available in many countries, however, for the treatment of certain hormone-dependent neoplasms including carcinoma of the prostate and postmenopausal breast cancer. (Reference: (WHODI) WHO Drug Information, 77.1, 16, 1977)
  • Allgemeine Beschreibung At first glance, it might be surprising that synthetic nonsteroidal molecules such as diethylstilbestrol (DES) could have the same activity as estradiol or other estrogens. DES can be viewed, however, as a form of estradiol with rings B and C open and a six-carbon ring D. The activity of DES analogs was explained in 1946. It was proposed that the distance between the two DES phenol OH groups was the same as the 3-OH to 17-OH distance of estradiol; therefore, they could both fit the same receptor. Medicinal chemists have shown the OH-to-OH distance to be actually 12.1 ? in DES and 10.9 ? in estradiol. In aqueous solution, however, estradiol has two water molecules that are hydrogen bonded to the 17-OH. If one of the two water molecules is included in the distance measurement, there is a perfect fit with the two OH groups of DES. This suggests that water may have an important role for estradiol in its receptor site.
    It is now generally accepted that the estrogens must have a phenolic moiety for binding, but some investigators propose that the receptor may be flexible enough to accommodate varying distances between the two key hydroxyls. This point about estrogens needing a phenolic ring for high-affinity binding to the ER is critical. Steroids with a phenolic A ring and related phenolic compounds lack high-affinity binding to the other steroid hormone receptors.
  • Allgemeine Beschreibung Odorless tasteless white crystalline powder.
  • Air & Water Reaktionen Insoluble in water.
  • Reaktivität anzeigen Diethylstilbestrol is incompatible with strong oxidizing agents, strong bases, acid chlorides and acid anhydrides .
  • Brandgefahr Flash point data for Diethylstilbestrol are not available; however, Diethylstilbestrol is probably combustible.
  • Sicherheitsprofil Confirmed carcinogen producing skin, liver, and lung tumors in exposed humans as well as uterine and other reproductive system tumors in the female offspring of exposed women. Experimental carcinogenic, neoplas tigenic, tumorigenic, and teratogenic data. A transplacental carcinogen. A human teratogen by many routes. Poison by intraperitoneal and subcutaneous routes. It causes glandular system effects by sktn contact. Human reproductive effects by ingestion: abnormalspermatogenesis; changes in testes, epididymis, and sperm duct; menstrual cycle changes or disorders; changes in female ferulity; unspecified maternal effects; developmental abnormalities of the fetal urogenital system; germ cell effects in offspring; and delayed effects in newborn. Implicated in male impotence and enlargement of male breasts. Other experimental reproductive effects. Mutation data reported. When heated to decomposition it emits acrid smoke and fumes. See also ETHINYL ESTRADIOL.
  • Carcinogenicity Diethylstilbestrol is known to be a human carcinogen based on sufficient evidence of carcinogenicity from studies in humans.
  • Verordnung (Regulations) Environmental Protection Agency (EPA)
    Comprehensive Environmental Response, Compensation, and Liability Act Reportable quantity (RQ) = 1 lb.
    Resource Conservation and Recovery Act
    Listed Hazardous Waste: Waste code for which the listing is based wholly or partly on the presence of diethylstilbestrol = U089. Listed as a hazardous constituent of waste.
    Food and Drug Administration (FDA)
    All oral and parenteral drug products containing greater than 25 mg per unit dose of diethylstilbestrol were removed from the market because they were found to be unsafe or not effective, and they may not be compounded.
    Diethylstilbestrol is prohibited from extralabel use in food-producing animals.
Diethylstilbestrol Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Diethylstilbestrol Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
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56-53-1, Diethylstilbestrol Verwandte Suche:
  • -Amino-3-(phosphonomethyl)-2-quinoxalinepropanoic Acid
  • Dibromonicotinate
  • Methyl 4,&#x200B
  • -Phenyl-2-piperidinemethanol (Mixture)
  • -Methyl-N-(phenylmethyl)benzenepropanamine
  • -(Bromomethyl)-2,4-dichlorobenzenemethanol
  • -Methyl-N-(phenylmethyl)benzenepropanamine-d3
  • Amino-hexanoic Acid Phenylmethyl Ester
  • -Amino-2-Benzofuranacetic Acid Methyl Ester
  • -dimethoxychalcone
  • -Ethyl-4,4&#39
  • -Truxillin
  • Amino-hexanoic Acid Phenylmethyl Ester 4,4&#39
  • alanyl-D-alanine
  • Aminocycloheptanecar&#x200B
  • boxylic Acid
  • -(Methylenecyclopropyl)glycine (Mixture of Diastereomers)
  • 4-bis(2-phenylethyl)-1,4-piperazinediacetic Acid 1,4-Diethyl Ester
  • 4S,2S,5S)-2,5-Dimethyl-3,6-dioxo-&alpha
  • Difluorocyclobutanol
  • -Methyl-5-indanethylamine-D6 Hydrochloride
  • -(phenylmethyl)benzenehexanoic Acid
  • -[[(1,1-Dimethylethoxy)carbonyl]amino]-&gamma
  • -hydroxy-&alpha
  • R)-&delta
  • R,&delta
  • 1-[2-(2,3-Dihydro-5-benzofuranyl)ethyl-d4]-&alpha
  • D-(+)-Trehalose, Dihydrate (&alpha
  • -D-glucopyranoside, D-Trehalose)
  • -Trehalose, Mycose, &alpha
  • d3)&#x200B
  • -Hexylcinnamaldehyde, stabilized
  • R-Brivaracetam-d7
  • -Diphenylprolinol Hydrochloride
  • Pentafluoropropanoic Acid-13C
  • (3S)-1-[2-(3-Ethenyl-4-hydroxyphenyl)ethyl]-&alpha
  • Aminopyridine-&#x200B
  • piperidinamine-d3
  • -[[(1S)-1-Carboxyethyl]amino]benzenebutanoic Acid
  • -[[(2-Amino-4-thiazolyl)(hydroxyimino)acetyl]amino]-1,2,5,7-tetrahydro-5-methyl-7-oxo-4H-Furo[3,4-d][1,3]thiazine-2-acetic Acid Sodium Salt||(Mixture of Diastereomers)
  • 4-[(2-Vinyl]-1-enthyne)-&alpha
  • -Methyl-N-[3-[4-(trifluoromethyl)phenyl]propyl]-1-naphthalenemethan|amine|
  • -(1-demethylethyl)-Verapamil Hydrochloride
  • (3R)-&alpha
  • -[(Acetyloxy)imino]-2-(formylamino)-4-thiazoleacetic Acid (Mixture)
  • -[(Acetyloxy)imino]-2-amino-4-thiazoleacetic Acid + (&alpha
  • -(methoxymethylene)benzeneacetic Acid Methyl Ester
  • E)-2-[(6-Chloro-4-pyrimidinyl)oxy]-&alpha
  • -Bromostyrene (~90%, ~1% Hydroquinone as stabilizer)
  • -Amino-4-octylbenzenebutanoic Acid
  • -Methyl-1-pentyl-1H-indole-3-ethanamine (2Z)-2-Butenedioate
  • methyl-1H-pyrrolo[3,4-b]pyridine Hydrochloride
  • diiodo-benzenepropanoic Acid
  • dinitrophenoxy)&#x200B
  • Leucine-&#x200B
  • -[(Acetyloxy)imino]-2-(formylamino)-4-thiazoleacetic Acid-13C,15N2
  • Tetrachlorododecane
  • azepin-&#x200B