Fosfestrol

FOSFESTROL Chemische Eigenschaften,Einsatz,Produktion Methoden

• Originator

  Stilphostrol,Dome,US,1955

• Verwenden

  Diethylstilbestrol Diphosphate USP (Stilphostrol) is used to treat Prostatic carcinoma.

• Definition

  ChEBI: Diethylstilbestrol diphosphate is an aryl phosphate. It is functionally related to a diethylstilbestrol.

• Manufacturing Process

  A solution of 1 part of α,α'-diethyl-4,4'-dihydroxystilbene in 5 parts of pyridine is added drop by drop to the strongly cooled solution of 2 parts of phosphorus-hydroxy chloride in 5 parts of pyridine. The mixture soon solidifies to a crystalline magma. It is allowed to stand in ice for ? hour and then for an hour at room temperature. The mass is then poured into an excess of saturated sodium bicarbonate solution. Unconsumed parent material is removed by extraction with ether. The aqueous solution is then mixed with 2 N hydrochloric acid, whereupon the primary phosphoric acid ester of α,α'- diethyl-4,4'-dihydroxystilbene of the formula is precipitated in the form of a voluminous white powder. By recrystallization or reprecipitation this ester may be further purified.
  

• Therapeutic Function

  Estrogen, Antitumor

• Allgemeine Beschreibung

  Odorless off-white crystalline powder.

• Air & Water Reaktionen

  Insoluble in water.

• Reaktivität anzeigen

  Organophosphates, such as FOSFESTROL, are susceptible to formation of highly toxic and flammable phosphine gas in the presence of strong reducing agents such as hydrides. Partial oxidation by oxidizing agents may result in the release of toxic phosphorus oxides.

• Brandgefahr

  Flash point data for FOSFESTROL are not available; however, FOSFESTROL is probably combustible.

FOSFESTROL Upstream-Materialien And Downstream Produkte

Fosfestrol Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global(34)Suppliers

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