Paroxypropion

Bezeichnung:Paroxypropion

CAS-Nr70-70-2

Englisch Name:4'-Hydroxypropiophenone

CBNumberCB8854142

SummenformelC9H10O2

Molgewicht150.17

MOL-Datei70-70-2.mol

Synonyma

Paroxypropion

Paroxypropion physikalisch-chemischer Eigenschaften

Schmelzpunkt	36-38 °C(lit.)
Siedepunkt	152-154 °C26 mm Hg(lit.)
Dichte	1.09 g/cm3 (20℃)
Brechungsindex	1.5360 (estimate)
FEMA	2005 \| ACETANISOLE
Flammpunkt	>230 °F
storage temp.	Store below +30°C.
Löslichkeit	methanol: 0.1 g/mL, clear
Aggregatzustand	Solid
pka	8.87±0.26(Predicted)
Farbe	White
Wasserlöslichkeit	0.34 g/l (15 ºC)
Merck	14,7044
BRN	907511
LogP	2.030
CAS Datenbank	70-70-2(CAS DataBase Reference)
NIST chemische Informationen	1-Propanone, 1-(4-hydroxyphenyl)-(70-70-2)
EPA chemische Informationen	1-Propanone, 1-(4-hydroxyphenyl)- (70-70-2)

Sicherheit

Kennzeichnung gefährlicher	Xn,Xi
R-Sätze:	36/37/38
S-Sätze:	37-24/25-36-26
WGK Germany	3
RTECS-Nr.	UH1925000
TSCA	Yes
HS Code	29145000
Toxizität	LD50 orally in Rabbit: 11800 mg/kg

Gefahreninformationscode (GHS)

4'-Hydroxypropiophenone Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S37:Geeignete Schutzhandschuhe tragen.
S24/25:Berührung mit den Augen und der Haut vermeiden.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
Chemische Eigenschaften
white powder
Verwenden
gonadotropic hormone inhibitor
Verwenden
p-Hydroxypropiophenone is a 4-hydroxyphenyl ketone used in the preparation of potential antitumor agents. p-Hydroxypropiophenone is a lignin degrradation product.
Verwenden
Intermediates of Liquid Crystals
synthetische
Preparation by Fries rearrangement of phenyl propionate
with aluminium chloride in refluxing carbon disulfide ? then at 130–150° for 2–3 h after solvent elimination (45–50%)
with aluminium chloride in nitrobenzene at 50° for 18 h (72%) or at ? 20° for 48 h (60%)
with aluminium chloride in nitromethane at 20° for 7–8 days (80%)
with aluminium chloride in chlorobenzene using microwave irradiation for ? 3 min at 106° (62%)
with aluminium chloride in ethylene dichloride at 95° for 5 h or in heptane at ? 80–90° for 7 h (36%), in benzene or in tetrachloroethane at 80°; with aluminium chloride in the presence of propionyl chloride at 50–60° for ? 6 h (49%)
with aluminium chloride without solvent at 50° for 10 h
with titanium tetrachloride in nitromethane at 20° for 7 days (56%) or ? without solvent at 50° for 10 h (39%)
with polyphosphoric acid at 100° (61%)
with boron trifluoride at 50° for 3 h (46%)
with stannic chloride at 50° for 3 h (10%).
Definition
ChEBI: P-Hydroxypropiophenone is a member of acetophenones.
Synthesis Reference(s)
The Journal of Organic Chemistry, 30, p. 2491, 1965 DOI: 10.1021/jo01018a528
Sicherheitsprofil
Poison by intraperitoneal, subcutaneous, and parenteral routes. An experimental teratogen. Other experimental reproductive effects. A flammable liquid. When heated to decomposition it emits acrid smoke and irritating fumes. See also KETONES.
target
Estrogen receptor
läuterung methode
4'-Hydroxypropiophenone [70-70-2] M 150.2, m 149o, b 140-145o/0.5mm, 8.05. Crystallise the phenone from H2O (m 149.8-150.2o) or EtOH (m 147o). The benzoyl derivative has m 117o, and the semicarbazone has m 183o (EtOH). [Beilstein 8 H 102, 8 II 104, 8 III 379.]

4'-Hydroxypropiophenone Upstream-Materialien And Downstream Produkte

Paroxypropion Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

70-70-2, 4'-Hydroxypropiophenone Verwandte Suche:

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