Erythromycin-2'-propanoat-dodecylsulfat

Bezeichnung:Erythromycin-2'-propanoat-dodecylsulfat

CAS-Nr3521-62-8

Englisch Name:Erythromycin Estolate

CBNumberCB1286137

SummenformelC52H97NO18S

Molgewicht1056.39

MOL-Datei3521-62-8.mol

Synonyma

Erythromycin, 2'-Propanoat, Dodecylsulfat (Salz)

Erythromycin-2'-propanoat-dodecylsulfat

Erythromycin-2'-propanoat-dodecylsulfat physikalisch-chemischer Eigenschaften

Schmelzpunkt	135-140°C dec.
Siedepunkt	743℃
Dichte	1.0053 (rough estimate)
Brechungsindex	1.6550 (estimate)
Flammpunkt	>110°(230°F)
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
Löslichkeit	chloroform: soluble4.0ML, clear, colorless (200 mg + 4.0 mL Chloroform)
pka	6.9(at 25℃)
Farbe	white
Wasserlöslichkeit	Freely soluble in organic solvents, practically insoluble in water /n
Sensitive	Light Sensitive
CAS Datenbank	3521-62-8

Sicherheit

Kennzeichnung gefährlicher	Xn,Xi
R-Sätze:	22-42/43-36/37/38
S-Sätze:	22-36-26
WGK Germany	3
RTECS-Nr.	KF5775000
HS Code	29419000
Toxizität	LD50 orally in rats: >5000 mg/kg (Goldenthal)

Gefahreninformationscode (GHS)

Erythromycin Estolate Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R22:Gesundheitsschädlich beim Verschlucken.
R42/43:Sensibilisierung durch Einatmen und Hautkontakt möglich.
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S22:Staub nicht einatmen.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
Beschreibung
Erythromycin estolate was synthesized by the Lilly Research Laboratories in 1959. It shows a higher and longer lasting serum level than erythromycin and the other esters, ethylsuccinate and stearate, when administered orally. This antibiotic is stable against gastric acids, and after oral absorption it is hydrolyzed gradually into erythromycin. Long-term usage of erythromycin estolate is toxic to the liver. Erythromycin ethylsuccinate [41342-53-4], (C43H75NO16, Mr 862.07) and erythromycin stearate [643-22-1] (C37H67NO13 · C18H36O2, Mr 1018.43) also have been used orally, and erythromycin lactobionate [3847-29-8] (C37H67NO13 · C12H22NO12, Mr 1092.25) has been used by intravenous administration and opthalmic topical application
Chemische Eigenschaften
Long Needles
Originator
Ilosone,Dista,US,1958
Verwenden
Used as an antibacterial agent. LD50 >5000 mg/kg for oral administration to rats.
Verwenden
Macrolides Antibiotics
Definition
ChEBI: Erythromycin estolate is an aminoglycoside sulfate salt and an erythromycin derivative. It has a role as an enzyme inhibitor. It contains an erythromycin A 2'-propanoate.
Manufacturing Process
16.7 grams of monopropionylerythromycin are dissolved in 50 ml of warm acetone. To the solution are added 6.4 grams of sodium lauryl sulfate dissolved in 50 ml of distilled water containing 2 ml of glacial acetic acid. The white crystalline precipitate of rnonopropionylerythromycin lauryl sulfate which separates is filtered off and dried. It melts at about 135° to 137°C.
Trademarks
Antibio-aberel;Apo-erythro-s;Bio-exazol;Biometran;Biomicron;Chemthromycin;Cimetrin;Cusimicina balsamica;Doboiosol;Dowmicyn;Dreimicina;Duozplin vitaminado;Dynabiotal;Ees-200;Ees-400;E-mycine;Endoeritrina;Erimec;Erirobios;Eritrazol;Eritrobios;Eritrobiotic;Eritrocin;Eritrodes;Eritronicol;Eritropan;Eritroveinte;Eritrovienite;Eritrowolf;Eritro-wolf;Erymycin;Eryped;Ery-tar;Erythromictine;Erythro-prat;Ery-toxinal;Erytrodol;Erytro-prot;Eryt-toxinal;Espimina;Estimina;Estomiicina;Estomycin;Fesmicina;Ilosone pulvules;Ilosone ready-mix;Ilothycin;Kesso-mycin;Laucetin;Laurilin;Lauritran;Liferitrin;Loderm;Lubomycina;Lubomycine;Makrocyklina;Manilina;Marocid;Neo-ilolycina;Neo-iloticina;Niux;Novorythro;Propriocin enfante;Prospiocine;Proterytrin;Pulmomas;Purmycin;Ritromin;Roxo chemil;Roxochemil;Rp-mycin;Rubibacter;Selvicin;Spetrasone;Stella micina;Taimoxin;Togerin;Togrien;Tosinova;Tropoxin;Wyamycin s.
Therapeutic Function
Antibacterial
Weltgesundheitsorganisation (WHO)
Erythromycin estolate, a macrolide antibiotic, was introduced in 1958 for the treatment of gram-positive infections. By the early 1970s its use had been associated with a higher incidence of hepatic toxicity than that seen with other salts and esters of erythromycin. This led to its withdrawal by some regulatory authorities whereas others required the addition of a warning in the product information. Evidence that the estolate ester is more hepatotoxic than other salts or esters has subsequently been disputed. It has been claimed to be the most effective ester for treatment of Legionnaire's disease and preparations remain widely available. (Reference: (BMJOAE) British Medical Journal, 286, 1954, 1983)
Allgemeine Beschreibung
Erythromycin estolate, erythromycin propionate lauryl sulfate(Ilosone), is the lauryl sulfate salt of the 2＇-propionateester of erythromycin. Erythromycin estolate is acid stableand absorbed as the propionate ester. The ester undergoesslow hydrolysis in vivo. Only the free base binds to bacterialribosomes. Some evidence, however, suggests that theester is taken up by bacterial cells more rapidly than thefree base and undergoes hydrolysis by bacterial esteraseswithin the cells. The incidence of cholestatic hepatitis is reportedlyhigher with the estolate than with other erythromycinpreparations.
Erythromycin estolate occurs as long needles that aresparingly soluble in water but soluble in organic solvents. administration for the treatment of serious infections,such as Legionnaires disease, or when oral administrationis not possible. Solutions are stable for 1 week whenrefrigerated.

Erythromycin Estolate Upstream-Materialien And Downstream Produkte

Erythromycin-2'-propanoat-dodecylsulfat Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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