Domperidone maleate

Bezeichnung:Domperidone maleate

CAS-Nr99497-03-7

Englisch Name:Domperidone maleate

CBNumberCB9247961

SummenformelC26H28ClN5O6

Molgewicht541.99

MOL-Datei99497-03-7.mol

Domperidone maleate physikalisch-chemischer Eigenschaften

storage temp.	Hygroscopic, -20°C Freezer, Under inert atmosphere
Löslichkeit	Very slightly soluble in water, sparingly soluble in dimethylformamide, slightly soluble in methanol, very slightly soluble in ethanol (96 per cent).
Aggregatzustand	Solid
Farbe	White to Off-White

Gefahreninformationscode (GHS)

Domperidone maleate Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung
Domperidone maleate is a specific blocker of dopamine receptors. It speeds gastrointestinal peristalsis, causes prolactin release, and is used as antiemetic and tool in the study of dopaminergic mechanisms.
Chemische Eigenschaften
Domperidone maleate occurs as a white or almost white powder that exhibits polymorphism. It is very slightly soluble in water or alcohol.
Verwenden
Domperidone maleate (CAS# 99497-03-7); a form of Domperidone (D531100), a novel peripheral dopamine receptor antagonist that does not cross the blood-brain barrier; anti-emetic. Domperidone(Motilium) is a dopamine blocker and an antidopaminergic reagent.
synthetische
Domperidone was synthesized at Janssen Pharmaceutica in 1974 following their research on antipsychotic drugs. The present invention relates to synthesis of domperidone maleate. O-diaminobenzene is first cyclized and halogenated to form the first benzimidazolone intermediate; 1-carbethoxy-4-amino piperidine is halogenated, reduced, cyclized and hydrolyzed to form the second benzimidazolone intermediate; the two benzimidazolone intermediates are reacted to produce domperidone; and domperidone is finally reacted with maleic aicd to produce domperidone maleate.
https://patents.google.com/patent/CN1810805A/en
Indications
Domperidone may be useful for treatment of fescue toxicosis in pregnant mares or as a prokinetic or antiemetic agent in small animals. It has more effect on conditions with delayed gastric emptying than other GI hypomotility conditions. Via its effects on prolactin, domperidone may also be used to stimulate milk production in horses and small animals. Domperidone has been shown to increase plasma ACTH in horses with equine pituitary pars intermedia dysfunction (Equine Cushing’s) and may be useful in helping diagnose this condition.
Nebenwirkungen
Because plasma prolactin levels may be increased, galactorrhea or gynecomastia may result. Injectable products (now withdrawn) have been associated with arrhythmias in human patients with heart disease or hypokalemia. Rarely, somnolence or dystonic reac- tions have occurred in people.

Domperidone maleate Upstream-Materialien And Downstream Produkte

Domperidone maleate Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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