2-Methylbenzimidazole Struktur

2-Methylbenzimidazol

Bezeichnung:2-Methylbenzimidazol

CAS-Nr615-15-6

Englisch Name:2-Methylbenzimidazole

CBNumberCB5439553

SummenformelC8H8N2

Molgewicht132.16

MOL-Datei615-15-6.mol

Synonyma

2-Methylbenzimidazol

2-Methylbenzimidazol physikalisch-chemischer Eigenschaften

Schmelzpunkt	175-177 °C (lit.)
Siedepunkt	234.08°C (rough estimate)
Dichte	1.1083 (rough estimate)
Brechungsindex	1.6013 (estimate)
storage temp.	Sealed in dry,Room Temperature
Löslichkeit	DMSO (Slightly), Methanol (Slightly)
Aggregatzustand	Crystalline Powder
pka	6.19(at 25℃)
Farbe	Light beige to brown
Wasserlöslichkeit	slightly soluble
BRN	112264
InChIKey	LDZYRENCLPUXAX-UHFFFAOYSA-N
CAS Datenbank	615-15-6(CAS DataBase Reference)
NIST chemische Informationen	1H-benzimidazole, 2-methyl-(615-15-6)
EPA chemische Informationen	1H-Benzimidazole, 2-methyl- (615-15-6)

Sicherheit

Kennzeichnung gefährlicher	Xn
R-Sätze:	22-37/38-41-20/21/22
S-Sätze:	26-39-45-44
WGK Germany	3
RTECS-Nr.	DD9100000
TSCA	Yes
HS Code	29339990

Gefahreninformationscode (GHS)

2-Methylbenzimidazole Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R22:Gesundheitsschädlich beim Verschlucken.
R37/38:Reizt die Atmungsorgane und die Haut.
R41:Gefahr ernster Augenschäden.
R20/21/22:Gesundheitsschädlich beim Einatmen,Verschlucken und Berührung mit der Haut.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S39:Schutzbrille/Gesichtsschutz tragen.
Chemische Eigenschaften
light beige to brown crystalline powder. Soluble in alcohol, ether, hot water and sodium hydroxide solution, insoluble in benzene.
Verwenden
- 2-Methylbenzimidazole is an important pharmacophore widely used in medicinal chemistry for the synthesis of various antibacterial and antifungal agents.
- It can be used as a key precursor to synthesize substituted benzimidazo[1,2-a]quinolones.
- It can be used in the synthesis of reversible solid-to-liquid phase transition coordination polymer crystals.
- 2-Methylbenzimidazole also exhibits corrosion inhibition.
Definition
ChEBI: 2-Methyl-1H-benzo[d]imidazole is a member of benzimidazoles.
synthetische
2-Methylbenzimidazole is synthesized by the condensation of o-phenylenediamine with acetic acid. The mixture of o-phenylenediamine and acetic acid is heated at 100°C for 2 hours and then cooled slowly. 10% sodium hydroxide solution is added slowly to the mixture until it is slightly alkaline. The mixture is filtered and washed with cold water. The crude product is then recrystallized with water and decolorized with activated charcoal to obtain the final product. The yield is 68%.
Synthesis Reference(s)
Journal of Heterocyclic Chemistry, 26, p. 1163, 1989 DOI: 10.1002/jhet.5570260447
Chemical and Pharmaceutical Bulletin, 17, p. 1153, 1969 DOI: 10.1248/cpb.17.1153
Sicherheitsprofil
Poison by intravenous route. Moderately toxic by ingestion. Experimental reproductive effects. Mutation data reported. When heated to decomposition it emits toxic fumes of NOx.

2-Methylbenzimidazole Upstream-Materialien And Downstream Produkte

2-Methylbenzimidazol Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

615-15-6, 2-Methylbenzimidazole Verwandte Suche:

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