Sevelamer hydrochloride

Gefahreninformationscode (GHS)

Sevelamer hydrochloride Chemische Eigenschaften,Einsatz,Produktion Methoden

• Originator

  Renagel,Chugai Pharmaceutical

• Verwenden

  Sevelamer HCl is used in the treatment of hyperphosphataemia in patients suffering from chronic kidney disease.

• Verwenden

  Sevelamer hydrochloride is a noncalcemic phosphate binder for the treatment of hyperphosphatemia in chronic renal failure or patients suffering from chronic kidney disease.

• Definition

  ChEBI: Sevelamer hydrochloride is an epoxide.

• Manufacturing Process

  Poly(allylamine hydrochloride) (50% w/w, 426 kg) was charged to a 1000 L reactor and water (200 L) was added. Sodium hydroxide solution (32% w/w, 208 kg) was added, followed by 85 L of water. The mixture was stirred for 1 h and filtered to a 2500 L reactor. The transfer line was rinsed with water (217 kg) and acetonitrile (1300 L) added. The temperature was adjusted to 40°C and epichlorohydrin (20 kg) added. The mixture was stirred at 40° to 50°C for 1.5 h and then heated to reflux for 16 h. The resulting product slurry may be isolated and washed in decanter centrifuge.
  

• Trademarks

  Renagel (Genzyme).

• Therapeutic Function

  Antihyperphosphatemic

• Veterinary Drugs and Treatments

  Sevalamer may be useful for treating hyperphosphatemia associated with chronic renal failure, particularly when oral aluminum salts are not tolerated.

Sevelamer hydrochloride Upstream-Materialien And Downstream Produkte

Sevelamer hydrochloride Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global(177)Suppliers

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