Sevelamer carbonate

Bezeichnung:Sevelamer carbonate

CAS-Nr845273-93-0

Englisch Name:Sevelamer carbonate

CBNumberCB32128754

SummenformelC7H14ClNO4

Molgewicht211.64

MOL-Datei845273-93-0.mol

Sevelamer carbonate physikalisch-chemischer Eigenschaften

storage temp.	Room Temperature, under inert atmosphere
Löslichkeit	<4.74mg/mL in DMSO
Aggregatzustand	Solid
Farbe	White to Pale Beige
InChI	InChI=1S/C3H5ClO.C3H7N.CH2O3/c4-1-3-2-5-3;1-2-3-4;2-1(3)4/h3H,1-2H2;2H,1,3-4H2;(H2,2,3,4)
InChIKey	PADGNZFOVSZIKZ-UHFFFAOYSA-N
SMILES	C(O)(O)=O.C(C1OC1)Cl.C(=C)CN

Gefahreninformationscode (GHS)

Sevelamer carbonate Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung
Sevelamer carbonate (SC) is a non-absorbed phosphate binding crosslinked polymer, with the same polymeric structure as sevelamer hydrochloride, in which carbonate replaces chloride as the counterion. SC has been found to have the same safety and efficacy profile as Sevelamer HCl in HD patients.
Sevelamer carbonate(Renvela) is a nonaluminum, non-calcium-basedphosphorus binder that traps phosphorus in the bowel through ion exchange and hydrogen binding. This drug replaced sevelamer hydrochloride(Renagel) and has an advantage of not generating an acid load, as its precursor, sevelamer hydrochloride, did. It also has the advantage of lowering LDL cholesterol due to gut binding of bile acids.
Verwenden
Control of serum phosphorus in patients with chronic kidney disease (phosphate binder).
Verwenden
Sevelamer Carbonate, a non-?absorbed polymer is an oral phosphate binder in patients with kidney failure. It is reported that Sevelamer Carbonate is less likely to cause hypercalcemia, low levels of PTH, and progressive coronary and aortic calcification in hemodialysis patients than calcium-?based phosphate binders.
Nebenwirkungen
The Common Side Effects of Sevelamer carbonate:
Vomiting (22%), Nausea (20%), Diarrhea (19%), Indigestion (16%), Stomach pain (9%), Feeling gassy (8%), and Constipation (8%).
The Serious Side Effects of Sevelamer carbonate:
Stomach or intestine problems: bowel blockage, bleeding ulcers, severe stomach pain, blood in your stool.
Mode of action
The active substance in Sevelamer carbonate Winthrop, sevelamer carbonate, is a phosphate binder. When taken with meals, it attaches in the gut to phosphate from the food, thereby preventing the phosphate from being absorbed into the body and helping to reduce phosphate levels in the blood.

Sevelamer carbonate Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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