Sevelamer

Sevelamer Chemische Eigenschaften,Einsatz,Produktion Methoden

• Verwenden

  Antihyper-phosphatemic.

• Trademarks

  Renagel (Genzyme).

• Pharmazeutische Anwendungen

  In patients on dialysis, Sevelamer or lanthanum salts can be used to maintain normal phosphate blood levels. Sevelamer is a polymer containing amine groups. These protonated amine groups can react with the negatively charged phosphate groups via ionic binding and prevent absorption of phosphate from the gut. Sevelamer is a hydrogel containing cross-linked polyallylamine chains. The negatively charged phosphate can be bound to the positively charged amine groups of the hydrogel in the intestines and removed via the faeces.

• Clinical Use

  Phosphate-binding agent

• Arzneimittelwechselwirkung

  Potentially hazardous interactions with other drugs
  Antibacterials: reduces bioavailability of ciprofloxacin.
  Ciclosporin: possibly reduces ciclosporin
  concentration.
  Calcitriol: absorption may be impaired by sevelamer.
  Mycophenolate: may reduce mycophenolate levels.
  Tacrolimus: possibly reduces tacrolimus
  concentration.
  Thyroid hormones: possibly reduces levothyroxine
  concentration.

• Stoffwechsel

  Sevelamer is not systemically absorbed.

Sevelamer Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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