(p-Toluolsulfonyl)methylisocyanid Produkt Beschreibung

Tosylmethyl isocyanide Struktur
36635-61-7
  • CAS-Nr.36635-61-7
  • Bezeichnung:(p-Toluolsulfonyl)methylisocyanid
  • Englisch Name:Tosylmethyl isocyanide
  • Synonyma:(p-Toluolsulfonyl)methylisocyanid
    TOSMIC;isocyanide;Tosylmethyl isocyani;LABOTEST-BB LT00159629;TOSYLMETHYL ISOCYANIDE;Tosylmethyleisocyanide;Tosylmethyl isocyanide,98%;Tosylmethy isocyanide ,98%;p-Toluenesulfonyl Isocyanide;TosMIC Tosylmethyl Isocyanide
  • CBNumber:CB5311774
  • Summenformel:C9H9NO2S
  • Molgewicht:195.24
  • MOL-Datei:36635-61-7.mol
(p-Toluolsulfonyl)methylisocyanid physikalisch-chemischer Eigenschaften
  • Schmelzpunkt: :109-113 °C(lit.)
  • Dichte :1.2721 (rough estimate)
  • Brechungsindex :1.5270 (estimate)
  • storage temp.  : -20°C
  • Löslichkeit :water: slightly soluble
  • Aggregatzustand :Liquid
  • Farbe :Clear
  • Wasserlöslichkeit :insoluble
  • Sensitive  :Moisture Sensitive
  • Merck  :14,9556
  • BRN  :3592382
  • InChIKey :BBNNLJMGPASZPD-UHFFFAOYSA-N
  • CAS Datenbank :36635-61-7(CAS DataBase Reference)
Sicherheit
  • Kennzeichnung gefährlicher :T,Xi
  • R-Sätze: :23/24/25
  • S-Sätze: :36/37-45-38-36/37/39-28A
  • RIDADR  :UN 2811 6.1/PG 3
  • WGK Germany  :3
  • F  :21
  • Hazard Note  :Irritant
  • HazardClass  :6.1(b)
  • PackingGroup  :III
  • HS Code  :29299000

Tosylmethyl isocyanide Chemische Eigenschaften,Einsatz,Produktion Methoden

  • R-Sätze Betriebsanweisung: R23/24/25:Giftig beim Einatmen, Verschlucken und Berührung mit der Haut.
  • S-Sätze Betriebsanweisung: S36/37:Bei der Arbeit geeignete Schutzhandschuhe und Schutzkleidung tragen.
    S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
    S38:Bei unzureichender Belüftung Atemschutzgerät anlegen.
    S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
  • Chemische Eigenschaften Pale yellow to light brown crystalline powder
  • Verwenden Reagent for use in the preparation of biologically active pyrroles and imidazoles.1,2
  • Verwenden Tosylmethyl Isocyanide is used as a synthetic reagent in the preparation of variety or biologically active heterocycles such as pyrroles and imidazoles. Tosylmethyl Isocyanide is reported to inhibit [ Fe]-hydrogenase with very high affinity.
  • Verwenden Versatile synthon in organic chemistry, especially in the synthesis of heterocyclic Compounds.
  • synthetische N-(p-Tolylsulfonylmethyl)formamide 1609:

    A 3-L, three-necked, round-bottomed flask, equipped with a mechanical stirrer, a condenser, and a thermometer, was charged with sodium p-toluenesulfinate 1606 (267 g, 1.5 mol). After the addition of water (750 mL), a 34–37% solution of formaldehyde 1607 (350 mL, 378 g, ca. 4.4 mol), formamide 1608 (600 mL, 680 g, 15 mol), and formic acid (200 mL, 244 g, 5.3 mol), the stirred reaction mixture was heated at 90 C°. The sodium p-toluenesulfinate dissolved during the heating, and the clear solution was kept at 90–95 C° for 2 h. It was then cooled in an ice/salt bath with continued stirring and further cooled overnight in a freezer at 20 C°. The white solid produced was collected by suction filtration. It was washed thoroughly in a beaker by stirring with three 250 mL portions of iced water. The product was dried under reduced pressure over phosphorus pentoxide at 70 C° to provide 134–150 g (42–47%) of crude N-(p-tolylsulfonylmethyl)formamide 1609; mp 106–110 C°. This product was sufficiently pure to be used directly in the following reaction.
  • läuterung methode Use an efficient fume cupboard. Purify TOSMIC by dissolving (50g) in CH2Cl2 (150mL) and passing it through a column (40x3cm) containing neutral alumina (100g) in CH2Cl2 and eluting with CH2Cl2. A nearly colourless solution (700mL) is collected, evaporated in vacuo and the residue (42-47g) of TOSMIC (m 113-114o dec) is recrystallised once from MeOH (m 116-117o dec). [Hoogenboom et al. Org Synth 57 102 1977, Lensen Tetrahedron Lett 2367 1972.] It also crystallises from EtOH (charcoal) [Saito & Itano, J Chem Soc, Perkin Trans 1 1 1986].
Tosylmethyl isocyanide Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
(p-Toluolsulfonyl)methylisocyanid Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
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36635-61-7, Tosylmethyl isocyanide Verwandte Suche:
  • 1-[(isocyanomethyl)sulfonyl]-4-methyl-benzen
  • Tosylmethy isocyanide ,98%
  • Tosylmethyl isocyani
  • Isocyanomethyl 4-methylphenyl sulphone
  • Toluenesulfonyl Methyl isocyanide
  • 4-[(Isocyanomethyl)sulphonyl]toluene, (Toluene-4-sulphonyl)methyl isocyanide
  • (p-Toluensulfonyl)methylisocyanide
  • (p-Tolylsulfonyl)methyl isocyanide, TosMIC, Tosylmethyl isocyanide
  • (4-Methylphenylsulfonylmethyl) isocyanide
  • 4-Methylphenylsulfonylmethyl isocyanide
  • Tosylmethyl isocyanide,98%
  • p-Toluenesulfonyl Isocyanide
  • P-tolysulfonylmethylisocyanide
  • TosylMethyl isocyanide, 98% 25GR
  • TosylMethyl isocyanide, 98% 5GR
  • 4-TolylsulfonylMethyl Isocyanide
  • IsocyanoMethyl p-Tolyl Sulfone
  • TosMIC Tosylmethyl Isocyanide
  • p-ToluenesulonylMethy isocyanide
  • 4-[(Isocyanomethyl)sulphonyl]toluene, (Toluene-4-sulphonyl)methyl isocyanide, TosMIC
  • TosylMethyl Isocyanide, TOSMIC
  • 4-TOLUENESULFONYLMETHYL ISOCYANIDE FOR S
  • METHYLIDYNE[[(4-METHYLPHENYL)SULFONYL]METHYL]AMMONIUM
  • LABOTEST-BB LT00159629
  • BENZENE, 1-[(ISOCYANOMETHYL)SULFONYL]-4-METHYL-
  • 1-[(ISOCYANOMETHYL)SULFONYL]-4-METHYLBENZENE
  • 4-TOLUENSULFONYLMETHYL ISOCYANIDE
  • 4-TOLUENESULPHONYLMETHYL ISOCYANIDE
  • 4-TOLUENESULFONYLMETHYL ISOCYANIDE
  • P-TOLUENESULFONYLMETHYL ISOCYANIDE
  • P-TOLUENESULPHONYLMETHYL ISOCYANIDE
  • (P-TOLYLSULFONYL)METHYL ISOCYANIDE
  • TOSYLMETHYL ISOCYANIDE
  • TOSMIC
  • TOLUENE-4-SULFONYLMETHYL ISOCYANIDE
  • 4-Toluenesulfonylmethyl isocyanate
  • p-Toluenesulfonylmethyl isocyanide, 98+%
  • p-Toluenesulfonylmethylisocyanide,97+%
  • 1-ISOCYANOMETHANESULFONYL-4-METHYL-BENZENE
  • p-toluenesulfonylmethyl isocyande
  • p-Toluenesulfonylmethyl isocyanate
  • P-TOLUENESULFONYLMETHYL ISOCYANIDE 98%
  • p-ToluenesulfonylMethyl isocyanide, 98.5%
  • <i>p</i>-Toluenesulfonylmethyl Isocyanide
  • 4-Toluenesulfonylmethyl isocyanide for synthesis
  • Tosylmethyleisocyanide
  • 1-[(ISOCYANOMETHYL)SULFONYL]-
  • isocyanide
  • Tosylmethyl isocyanide, 98%, for synthesis
  • 36635-61-7
  • CH3C6H4SO2CH2NC
  • Organic Building Blocks
  • Isocyanides
  • Nitrogen Compounds
  • Sulfur Compounds (for Synthesis)
  • Building Blocks
  • cyanide
  • Building Blocks