3-(3,4-Dihydroxyphenyl)propionsure

Bezeichnung:3-(3,4-Dihydroxyphenyl)propionsure

CAS-Nr1078-61-1

Englisch Name:Dihydrocaffeic acid

CBNumberCB1439090

SummenformelC9H10O4

Molgewicht182.17

MOL-Datei1078-61-1.mol

Synonyma

3-(3,4-Dihydroxyphenyl)propionsure

3-(3,4-Dihydroxyphenyl)propionsure physikalisch-chemischer Eigenschaften

Schmelzpunkt	136-139 °C(lit.)
Siedepunkt	418℃
Dichte	1.398
Flammpunkt	220℃
storage temp.	Inert atmosphere,Room Temperature
Löslichkeit	DMSO (Slightly), Methanol (Slightly)
Aggregatzustand	Solid
pka	4.75±0.10(Predicted)
Farbe	Pale Beige to Pale Brown
Wasserlöslichkeit	Slightly soluble in water.
BRN	2213449
InChI	InChI=1S/C9H10O4/c10-7-3-1-6(5-8(7)11)2-4-9(12)13/h1,3,5,10-11H,2,4H2,(H,12,13)
InChIKey	DZAUWHJDUNRCTF-UHFFFAOYSA-N
SMILES	C1(CCC(O)=O)=CC=C(O)C(O)=C1
LogP	0.115 (est)
CAS Datenbank	1078-61-1(CAS DataBase Reference)

Sicherheit

Kennzeichnung gefährlicher	Xi
R-Sätze:	36/37/38
S-Sätze:	26-36
WGK Germany	3
RTECS-Nr.	MW5143500

Gefahreninformationscode (GHS)

Dihydrocaffeic acid Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Beschreibung
Dihydrocaffeic acid is a polyphenol that has diverse biological activities, including antioxidant, neuroprotective, and enzyme inhibitory properties. Dihydrocaffeic acid scavenges ABTS (; IC₅₀ = 81.86 μg/ml) and 2,2-diphenyl-1-picrylhydrazyl (DPPH; ; IC₅₀ = 192.86 μg/ml) radicals and increases the survival of RGC-5 mouse retinal ganglion cells under hypoxic conditions and in the presence of S-nitroso-N-acetyl-D,L-penicillamine (SNAP; ) in a concentration-dependent manner. It also decreases endothelial nitric oxide synthase (eNOS) activity in EA.hy926 human endothelial cells in a concentration-dependent manner. In vivo, dihydrocaffeic acid (30 mg/kg) decreases infarct size in a rat model of transient ischemia induced by middle cerebral artery occlusion (MCAO).
Chemische Eigenschaften
Brown Solid
Verwenden
3-(3,4-Dihydroxyphenyl)propionic acid it can be used to produce 3-(3,4-dihydroxy-phenyl)-propionic acid octyl ester by heating.
Verwenden
Dihydrocaffeic Acid is a natural product containing a catechol group with an α,β-unsaturated carboxylic acid chain. Dihydrocaffeic Acid has been shown to have hepatoprotective activity. Dihydrocaffei c Acid is a metabolite of Caffeic Acid (C08000) with potent antioxidant properties.
Definition
ChEBI: A monocarboxylic acid that is 3-phenylpropionic acid substituted by hydroxy groups at positions 3 and 4. It is a metabolite of caffeic acid and exhibits antioxidant activity.

Dihydrocaffeic acid Upstream-Materialien And Downstream Produkte

3-(3,4-Dihydroxyphenyl)propionsure Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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