Sulfapyridin

Bezeichnung:Sulfapyridin

CAS-Nr144-83-2

Englisch Name:Sulfapyridine

CBNumberCB8423160

SummenformelC11H11N3O2S

Molgewicht249.29

MOL-Datei144-83-2.mol

Synonyma

Sulfapyridin

Sulfapyridin physikalisch-chemischer Eigenschaften

Schmelzpunkt	191-193°C
Siedepunkt	473.5±51.0 °C(Predicted)
Dichte	1.3220 (rough estimate)
Brechungsindex	1.6740 (estimate)
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
Löslichkeit	DMSO (Slightly), Methanol (Slightly)
pka	pKa 8.48(H2O t = 25 I = 0.05) (Uncertain)
Farbe	White to Off-White
Wasserlöslichkeit	<0.1 g/100 mL at 22 ºC
Merck	14,8938
BRN	222065
Stabilität	Stable. Combustible. Protect from light. Incompatible with strong oxidizing agents.
CAS Datenbank	144-83-2(CAS DataBase Reference)
NIST chemische Informationen	Sulfapyridine(144-83-2)
EPA chemische Informationen	Sulfapyridine (144-83-2)

Sicherheit

Kennzeichnung gefährlicher	Xi
R-Sätze:	36/37/38
S-Sätze:	22-24/25-36-26
WGK Germany	2
RTECS-Nr.	DA9625000
HazardClass	IRRITANT
HS Code	29350010
Toxizität	LD50 orally in mice: 7.5 mg/g (Wien)

Gefahreninformationscode (GHS)

Sulfapyridine Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S22:Staub nicht einatmen.
S24/25:Berührung mit den Augen und der Haut vermeiden.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
Beschreibung
Sulfapyridine is a sulfonamide antibiotic with antibacterial and anti-inflammatory activities. It is also a metabolite of sulfasalazine formed through bacterial conversion in the colon. It is active against strains of Y. enterocolitica and Salmonella (MICs = 3.1-25 and 25-100 μg/ml, respectively), as well as S. aureus (MBC = 0.8 μM). It is an inhibitor of recombinant P. carinii dihydropteroate synthetase (DHPS; IC₅₀ = 0.18 μM). Sulfapyridine scavenges peroxyl radicals in an oxygen radical absorbance capacity (ORAC) assay. It inhibits histamine release induced by compound 48/80 from isolated rat peritoneal mast cells in a dose-dependent manner. Sulfapyridine (1 μg/kg) also inhibits compound 48/80-induced systemic allergic reaction in rats. Formulations containing sulfapyridine have previously been used in the treatment of dermatological conditions and ulcerative colitis.
Chemische Eigenschaften
White to Off-White Solid
Verwenden
Used in treatment of dermatitis herpetiformis; antibacterial.
Verwenden
antibacterial, dermatitis herpetiformis therapy
Definition
ChEBI: A sulfonamide consisting of pyridine with a 4-aminobenzenesulfonamido group at the 2-position.
Antimicrobial activity
Like all sulfanilamides, this drug possesses antibacterial activity with respect to streptococci, pneumococci, staphylococci, meningococci, gonococci, colon bacillus, pathogenic dysentery, and so on. It is a long-lasting drug. Synonyms of this drug are bacillopirin, plurazol, sulfidin, and thiaseptol.
Allgemeine Beschreibung
Sulfapyridine’s plasma half-life is 9 hours.This compound is a white, crystalline, odorless, and tastelesssubstance. It is stable in air but slowly darkens on exposureto light. It is soluble in water (1:3,500), in alcohol(1:440), and in acetone (1:65) at 25°C. It is freely soluble indilute mineral acids and aqueous solutions of sodium andpotassium hydroxide. The pKa is 8.4. Its outstanding effectin curing pneumonia was first recognized by Whitby; however,because of its relatively high toxicity, it has been supplantedlargely by sulfadiazine and sulfamerazine. Severalcases of kidney damage have resulted from acetylsulfapyridinecrystals deposited in the kidneys. It also causes severenausea in most patients. Because of its toxicity, it is usedonly for dermatitis herpetiformis.
Sulfapyridine was the first drug to have an outstandingcurative action on pneumonia. It gave impetus to the studyof the whole class of N¹ heterocyclically substituted derivativesof sulfanilamide.
Allgemeine Beschreibung
Odorless or almost odorless white or yellowish-white crystalline powder. Very slightly bitter taste. Aqueous solution is neutral.
Air & Water Reaktionen
Insoluble in water.
Reaktivität anzeigen
Sulfapyridine is an amino acid. Slowly darkens on exposure to light . Soluble in both acidic and basic aqueous solutions
Brandgefahr
Flash point data for Sulfapyridine are not available; however, Sulfapyridine is probably combustible.
Sicherheitsprofil
Moderately toxic by intraperitoneal and intravenous routes. Slightly toxic by ingestion. Experimental reproductive effects. Human mutation data reported. Questionable carcinogen with experimental tumorigenic data. When heated to decomposition it emits very toxic fumes of NO, and SOx.
Synthese
Sulfapyridine, N1 -(2-pyridyl)-sulfanilamide (33.1.21), is also synthesized by an analogous scheme from 4-acetylaminobenzenesulfonyl chloride and 2-amino pyridine.
läuterung methode
Crystallise sulfapyridine from 90% acetone and dry it at 90o. Its solubility in Me2CO, EtOH and H2O is 1.5%, 0.22% and 0.02%, respectively. [Winterbottom J Am Chem Soc 62 160 1940, Beilstein 22 III/IV 3978.]

Sulfapyridine Upstream-Materialien And Downstream Produkte

Sulfapyridin Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

144-83-2, Sulfapyridine Verwandte Suche:

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