Nifekalant hydrochloride

Bezeichnung:Nifekalant hydrochloride

CAS-Nr130656-51-8

Englisch Name:Nifekalant hydrochloride

CBNumberCB8325413

SummenformelC19H28ClN5O5

Molgewicht441.91

MOL-Datei130656-51-8.mol

Nifekalant hydrochloride physikalisch-chemischer Eigenschaften

Schmelzpunkt	172-174°
storage temp.	Refrigerator
Löslichkeit	DMSO (Slightly, Heated), Methanol (Slightly, Heated), Water (Slightly)
Aggregatzustand	Solid
pka	7.05(at 25℃)
Farbe	Light Yellow to Yellow
CAS Datenbank	130656-51-8(CAS DataBase Reference)

Gefahreninformationscode (GHS)

Nifekalant hydrochloride Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung
Nifekalant is a novel and pure class III anti-arrhythmic agent introduced in Japan as Shinbit injection for the treatment of serious ventricular arrhythmias. It can be synthesized in 3 steps with a final assembly of two ethanolamine blocks. Nifekalant is a non-selective blocker of myocardial repolarizing potassium currents and is completely devoid of any β-adrenergic blocking effect . In hearts from different species, Nifekalant significantly prolonged action potential duration, atrial and ventricular refractory periods in in situ and in isolation studies. In intact animals, hemodynamic parameters were not affected by doses up to 1 mg/kg. The specific characteristics of its voltage- and timedependent K+ current blockade might differentiate Nifekalant from other class III agents currently in use.
Beschreibung
Nifekalant is a class III antiarrhythmic agent that has been shown to be beneficial to initial resuscitation after cardiac arrest in clinical trials. It blocks the rapidly activating delayed rectifier potassium channel (I_Kr; IC₅₀ = 10 μM). Nifekalant is also inhibits the human multidrug and toxin extrusion (MATE) transporter 1 (MATE1; IC₅₀ = 6.5 μM).
Chemische Eigenschaften
Yellow Solid
Originator
Mitsui (Japan)
Verwenden
Nifekalant Hydrochloride is a class III antiarrhythmic agent. Nifekalant Hydrochloride is used in the treatment of patients with extensive anterior infarction and severe ventricular dysfunction.
Definition
ChEBI: Nifekalant hydrochloride is an amine. It contains a Nifekalant.
Trademarks
Shinbit

Nifekalant hydrochloride Upstream-Materialien And Downstream Produkte

Nifekalant hydrochloride Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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