1-BOC-Piperazine

Bezeichnung:1-BOC-Piperazine

CAS-Nr57260-71-6

Englisch Name:1-BOC-Piperazine

CBNumberCB8268275

SummenformelC9H18N2O2

Molgewicht186.25

MOL-Datei57260-71-6.mol

1-BOC-Piperazine physikalisch-chemischer Eigenschaften

Schmelzpunkt	43-47 °C(lit.)
Siedepunkt	98-100
Dichte	1.030±0.06 g/cm3(Predicted)
Flammpunkt	>230 °F
storage temp.	Keep in dark place,Inert atmosphere,2-8°C
Löslichkeit	Soluble in DMSO
pka	8.45±0.10(Predicted)
Aggregatzustand	Low Melting Crystalline Mass
Farbe	White to light yellow
Wasserlöslichkeit	Soluble in ethyl acetate, methanol and water.
Sensitive	Air Sensitive
BRN	879985
InChIKey	CWXPZXBSDSIRCS-UHFFFAOYSA-N
CAS Datenbank	57260-71-6(CAS DataBase Reference)
NIST chemische Informationen	T-butyl 1-piperaziencarboxylate(57260-71-6)

Sicherheit

Kennzeichnung gefährlicher	Xi
R-Sätze:	36/37/38
S-Sätze:	26-36
RIDADR	3263
WGK Germany	3
F	3-10-34
HazardClass	IRRITANT
HS Code	29335995

Gefahreninformationscode (GHS)

1-BOC-Piperazine Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Chemische Eigenschaften
Waxy Solid
Verwenden
1-Boc-piperazine may be used in:
- preparation of series of (m-phenoxy)phenyl substituted piperazine derivatives
- termination step during synthesis of α,β-poly(2-oxazoline) lipopolymers via living cationic ring opening polymerization
- preparation of monosubstituted piperazines, e.g. in the synthesis of indazole DNA gyrase inhibitors
Verwenden
1-Boc-piperazine undergoes Buchwald-Hartwig amination with various aryl halides to form corresponding amine derivatives. It can be used to synthesize monosubstituted piperazine intermediates of many bioactive molecules and piperazine containing drug substances, such as trazodone.
Application
Tert-Butyl 1-piperazinecarboxylate, also known as Olaparib Impurity 7, is an impurity of Olaparib. Olaparib is used alone or in combination with bevacizumab (Avastin) to help maintain the response of certain types of ovarian (female reproductive organs where eggs are formed), fallopian tube (tube that transports eggs released by the ovaries to the uterus), and peritoneal (layer of tissue that lines the abdomen) cancer in people who have completely responded or partially responded to their first or later chemotherapy treatments. Olaparib is also used to treat certain types of breast cancer that has spread to other parts of the body and has not improved or has worsened after treatment with other therapies. It is also used to treat certain types of early breast cancer in people who have already been treated with other chemotherapy treatments.
Allgemeine Beschreibung
1-Boc-piperazine is an N-Boc protected piperazine. Crosscoupling of 1-Boc-piperazine with aryl iodides using CuBr/1,1′-bi-2-naphthol (catalyst) and K₃PO₄ (base) has been reported. 1-Boc-piperazine undergoes Buchwald-Hartwig coupling reactions with aryl halides. 1-Boc-piperazine can be prepared in 80% yield via solvent-free N-Boc protection catalyzed by iodine.

1-BOC-Piperazine Upstream-Materialien And Downstream Produkte

1-BOC-Piperazine Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

57260-71-6, 1-BOC-Piperazine Verwandte Suche:

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